AAV vector-derived elements integrate into Cas9-generated double-strand breaks and disrupt gene transcription

Autor: Bazick, Hannah O., Mao, Hanqian, Niehaus, Jesse K., Wolter, Justin M., Zylka, Mark J.

Publikováno v: In Molecular Therapy 6 November 2024 32(11):4122-4137

Development And Validation Of Painface, A Software Platform That Simplifies And Standardizes Mouse Grimace Analyses

Autor: Zylka, Mark J., McCoy, Eric S., Park, Sang Kyoon, Patel, Rahul P., Ryan, Dan F., Mullen, Zachary J., Nesbitt, Jacob J., Lopez, Joshua E., Taylor-Blake, Bonnie, Krantz, James L., Hu, Wenxin, Garris, Rosanna L., Lima, Lucas V., Sotocinal, Susana G., Austin, Jean-Sebastien, Kashlan, Adam D., Jimenez, Jessica A., Shah, Sanya, Trocinski, Abigail K., Vanden, Kelly A., Major, Rami M., Bazick, Hannah O., Klein, Morgan R., Mogil, Jeffrey S., Wu, Guorong

Publikováno v: In The Journal of Pain April 2023 24(4) Supplement:35-36

Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA.

Autor: Wolter, Justin M., Mao, Hanqian, Fragola, Giulia, Simon, Jeremy M., Krantz, James L., Bazick, Hannah O., Oztemiz, Baris, Stein, Jason L., Zylka, Mark J.

Publikováno v: Nature; 11/12/2020, Vol. 587 Issue 7833, p281-284, 4p

Long term rescue of Alzheimer's deficits in vivo by one-time gene-editing of App C-terminus.

Autor: Aulston BD; Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA., Gimse K; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53715, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA., Bazick HO; Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kramar EA; Department of Neurobiology and Behavior, School of Biological Sciences University of California, Irvine 92697-2695, USA., Pizzo DP; Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA., Parra-Rivas LA; Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA., Sun J; Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.; Present address: Department of Geriatrics and Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China., Branes-Guerrero K; Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.; Present address: Eli Lilly Pharmaceuticals, Indianapolis, IN, USA., Checka N; Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA., Bagheri N; Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA., Satyadev N; Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.; Present address: Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA., Carlson-Stevermer J; Synthego Corporation, 3696 Haven Ave Suite A, Redwood City, CA 94063.; Present address: Serotiny Inc., 329 Oyster Point Boulevard, 3rd Floor, South San Francisco, CA 94080., Saito T; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.; Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan., Saido TC; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan., Audhya A; Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA., Wood MA; Department of Neurobiology and Behavior, School of Biological Sciences University of California, Irvine 92697-2695, USA., Zylka MJ; Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Saha K; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53715, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA., Roy S; Department of Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.; Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 09. Date of Electronic Publication: 2024 Jun 09.