Výsledky vyhledávání

In silico design of influenza a virus artificial epitope-based T-cell antigens and the evaluation of their immunogenicity in mice

Autor: Denis V. Antonets, Larisa I. Karpenko, Ekaterina V Starostina, Tatyana N. Ilyicheva, Olga Y. Volkova, Bazhan Si, Olga N. Kaplina, Anastasiya Yu. Bakulina, Vasiliy Y. Marchenko

Publikováno v: Journal of Biomolecular Structure and Dynamics. 40:3196-3212

The polyepitope strategy is promising approach for successfully creating a broadly protective flu vaccine, which targets T-lymphocytes (both CD4+ and CD8+) to recognise the most conserved epitopes of viral proteins. In this study, we employed a compu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f8e3a1f8743e97e8bcfa4388abda93
https://doi.org/10.1080/07391102.2020.1845978

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Construction and Immunogenicity of Modified mRNA-Vaccine Variants Encoding Influenza Virus Antigens

Autor: Alexander A. Ilyichev, Larisa I. Karpenko, Sergei V Sharabrin, Georgiy Yu. Shevelev, Ekaterina V Starostina, Anton N. Chikaev, Bazhan Si, Vasiliy Y. Marchenko, A. P. Rudometov, Mariya B Borgoyakova, Denis N Antropov, Nadezhda B. Rudometova, Natalia V. Danilchenko, G. A. Stepanov, Anna E Lemza

Publikováno v: Vaccines, Vol 9, Iss 452, p 452 (2021)
Vaccines
Volume 9
Issue 5

Nucleic acid-based influenza vaccines are a promising platform that have recently and rapidly developed. We previously demonstrated the immunogenicity of DNA vaccines encoding artificial immunogens AgH1, AgH3, and AgM2, which contained conserved frag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca5fefdb587185cab4edd54401a2bd2
https://www.mdpi.com/2076-393X/9/5/452

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Delivery of mRNA Vaccine against SARS-CoV-2 Using a Polyglucin:Spermidine Conjugate

Autor: Mamedyar Sh Azaev, Anna V. Zaykovskaya, Natalya V Volkova, Ekaterina A Volosnikova, Oleg V. Pyankov, Inna A. Pyshnaya, Larisa I. Karpenko, A. P. Rudometov, B. N. Zaitsev, Bazhan Si, Alexander A. Ilyichev, Lyubov A Orlova, Mariya B Borgoyakova, Sergei V Sharabrin, Dmitry N. Shcherbakov, Nadezhda B. Rudometova

Publikováno v: Vaccines, Vol 9, Iss 76, p 76 (2021)
Vaccines
Volume 9
Issue 2

One of the key stages in the development of mRNA vaccines is their delivery. Along with liposome, other materials are being developed for mRNA delivery that can ensure both the safety and effectiveness of the vaccine, and also facilitate its storage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4da608e2fcf2dc7ae5e5ac50e5b27b
https://www.mdpi.com/2076-393X/9/2/76

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Immunogenicity and Protective Efficacy of Influenza A DNA Vaccines Encoding Artificial Antigens Based on Conservative Hemagglutinin Stem Region and M2 Protein in Mice

Autor: Durymanov Ag, Tatyana N. Ilyicheva, Olga N. Kaplina, Vasiliy Y. Marchenko, Larisa I. Karpenko, Ekaterina V Starostina, Svetlana F. Oreshkova, Bazhan Si, Denis V. Antonets

Publikováno v: Vaccines
Volume 8
Issue 3
Vaccines, Vol 8, Iss 448, p 448 (2020)

Background: Development of a universal vaccine capable to induce antibody responses against a broad range of influenza virus strains attracts growing attention. Hemagglutinin stem and the exposed fragment of influenza virus M2 protein are promising t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae322a09997bcf9169600d5ddaf7754

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In silico Designed Ebola Virus T-Cell Multi-Epitope DNA Vaccine Constructions Are Immunogenic in Mice

Autor: Ekaterina V Starostina, Alexander A. Ilyichev, Larisa I. Karpenko, Svetlana F. Oreshkova, Sofia A. Fedotova, Olga N. Kaplina, Bazhan Si, Sergei G. Dudko, Denis V. Antonets

Publikováno v: Vaccines
Volume 7
Issue 2
Vaccines, Vol 7, Iss 2, p 34 (2019)

Background: The lack of effective vaccines against Ebola virus initiates a search for new approaches to overcoming this problem. The aim of the study was to design artificial polyepitope T-cell immunogens&ndash
&ndash
candidate DNA vaccines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96dcde53bbb9e57c5a41330cb3e2890a

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Cationic Polymers for the Delivery of the Ebola DNA Vaccine Encoding Artificial T-Cell Immunogen

Autor: Olga N. Kaplina, Denis V. Antonets, Ekaterina V Starostina, Evgeny K. Apartsin, Anastasiya Yu Bakulina, Aliya G. Venyaminova, Ekaterina A Volosnikova, Larisa I. Karpenko, B. N. Zaitsev, Bazhan Si, Sergei G. Dudko, Alexander A. Ilyichev

Publikováno v: Vaccines, Vol 8, Iss 718, p 718 (2020)
Vaccines
Volume 8
Issue 4

Background: According to current data, an effective Ebola virus vaccine should induce both humoral and T-cell immunity. In this work, we focused our efforts on methods for delivering artificial T-cell immunogen in the form of a DNA vaccine, using gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740ced85a63d2251d104d4260b84849b
https://doi.org/10.3390/vaccines8040718

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Design of Polyepitope DNA Vaccine against Breast Carcinoma Cells and Analysis of Its Expression in Dendritic Cells

Autor: Denis V. Antonets, Zh. K. Nazarkina, Pavel P. Laktionov, Larisa I. Karpenko, E S Morozkin, Bazhan Si, A A Ilyichev, V. V. Vlasov, M V Khar'kova

Publikováno v: Bulletin of Experimental Biology and Medicine. 160:486-490

Polyepitope DNA vaccine inducing T-cell-mediated immune response against cancer-specific antigens is a promising tool for selective elimination of tumor cells. Breast cancer-specific polyepitope DNA vaccine was designed using TEpredict and PolyCTLDes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22fc394a4e4fe52168daca543104f2e8
https://doi.org/10.1007/s10517-016-3203-y

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