BMP signalling in human fetal ovary somatic cells is modulated in a gene-specific fashion by GREM1 and GREM2

Autor: Bayne, RA, Donnachie, DJ, Kinnell, HL, Childs, AJ, Anderson, RA

Publikováno v: Molecular Human Reproduction
Bayne, R A, Donnachie, D J, Kinnell, H L, Childs, A J & Anderson, R 2016, ' BMP signalling in human fetal ovary somatic cells is modulated in a gene-specific fashion by GREM1 and GREM2 ', Molecular Human Reproduction . https://doi.org/10.1093/molehr/gaw044

STUDY QUESTION: Do changes in the expression of bone morphogenetic proteins (BMPs) 2 and 4, and their antagonists Gremlin1 (GREM1) and Gremlin2 (GREM2) during human fetal ovarian development impact on BMP pathway activity and lead to changes in gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::22d9ad46ee141b93f88fa44894a2c1e7
https://researchonline.rvc.ac.uk/id/eprint/10514/1/10514.pdf

Could perturbed fetal development of the ovary contribute to the development of polycystic ovary syndrome in later life?

Autor: Hartanti MD; Discipline of Obstetrics and Gynaecology, School of Medicine, Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.; Faculty of Medicine, Trisakti University, Jakarta, Indonesia., Rosario R; Medical Research Council Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom., Hummitzsch K; Discipline of Obstetrics and Gynaecology, School of Medicine, Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia., Bastian NA; Discipline of Obstetrics and Gynaecology, School of Medicine, Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia., Hatzirodos N; Discipline of Obstetrics and Gynaecology, School of Medicine, Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia., Bonner WM; Discipline of Obstetrics and Gynaecology, School of Medicine, Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia., Bayne RA; Medical Research Council Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom., Irving-Rodgers HF; Discipline of Obstetrics and Gynaecology, School of Medicine, Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.; School of Medical Science, Griffith University, QLD, Australia., Anderson RA; Medical Research Council Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom., Rodgers RJ; Discipline of Obstetrics and Gynaecology, School of Medicine, Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia.

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The RHOX homeobox gene cluster is selectively expressed in human oocytes and male germ cells.

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