Defining the consequences of endogenous genetic variation within a novel family of Schizosaccharomyces pombe heterochromatin nucleating sequences

Autor: Arati Joshi, Meryl J Musicante, Bayly S Wheeler

Publikováno v: G3: Genes, Genomes, Genetics, Vol 11, Iss 8 (2021)

AbstractCentromeres are essential for genetic inheritance—they prevent aneuploidy by providing a physical link between DNA and chromosome segregation machinery. In many organisms, centromeres form at sites of repetitive DNAs that help establish the

Externí odkaz: https://doaj.org/article/b6bf8025ea854176bc90f4e244fbe1bf

The impact of local genome sequence on defining heterochromatin domains.

Autor: Bayly S Wheeler, Jared A Blau, Huntington F Willard, Kristin C Scott

Publikováno v: PLoS Genetics, Vol 5, Iss 4, p e1000453 (2009)

Characterizing how genomic sequence interacts with trans-acting regulatory factors to implement a program of gene expression in eukaryotic organisms is critical to understanding genome function. One means by which patterns of gene expression are achi

Externí odkaz: https://doaj.org/article/ace6e2f46b434eb88e4c0d9ace0d1b1e

Small RNAs, big impact: small RNA pathways in transposon control and their effect on the host stress response

Autor: Bayly S. Wheeler

Publikováno v: Chromosome Research. 21:587-600

Transposons are mobile genetic elements that are a major constituent of most genomes. Organisms regulate transposable element expression, transposition, and insertion site preference, mitigating the genome instability caused by uncontrolled transposi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8e78b22f57e039767c10c9c070e84d
https://doi.org/10.1007/s10577-013-9394-4

Uncoupling of Genomic and Epigenetic Signals in the Maintenance and Inheritance of Heterochromatin Domains in Fission Yeast

Autor: Kristin C. Scott, Huntington F. Willard, Bayly S. Wheeler, Brandon T. Ruderman

Publikováno v: Genetics

Many essential aspects of genome function, including gene expression and chromosome segregation, are mediated throughout development and differentiation by changes in the chromatin state. Along with genomic signals encoded in the DNA, epigenetic proc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72df65d700abad338485b5bb749b8ca5
http://europepmc.org/articles/PMC3276613

Condensin-driven remodelling of X chromosome topology during dosage compensation

Autor: Edward J. Ralston, Rachel Patton McCord, Bryan R. Lajoie, Barbara J Meyer, Satoru Uzawa, Qian Bian, Job Dekker, Bayly S. Wheeler, Emily Crane

Publikováno v: Crane, E; Bian, Q; McCord, RP; Lajoie, BR; Wheeler, BS; Ralston, EJ; et al.(2015). Condensin-driven remodelling of X chromosome topology during dosage compensation. Nature, 523(7559), 240-244. doi: 10.1038/nature14450. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/3vk5s10v
Nature

The three-dimensional organization of a genome plays a critical role in regulating gene expression, yet little is known about the machinery and mechanisms that determine higher-order chromosome structure. Here we perform genome-wide chromosome confor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4ff8a4aefd311af1e78dde68114395
https://pubmed.ncbi.nlm.nih.gov/26058053