Inhibition of TNF Receptor p55 By a Domain Antibody Attenuates the Initial Phase of Acid-Induced Lung Injury in Mice

Autor: Wilson, MR, Wakabayashi, K, Bertok, S, Oakley, C, Patel, BV, O'Dea, KP, Cordy, JC, Morley, PJ, Bayliffe, AI, Takata, M

Publikováno v: Frontiers in Immunology. 8

Background: Tumor necrosis factor-α (TNF) is strongly implicated in the development of acute respiratory distress syndrome (ARDS), but its potential as a therapeutic target has been hampered by its complex biology. TNF signals through two receptors,

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Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study.

Autor: Anderson BJ; Division of Pulmonary, Allergy and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 5036 Gates Building, Philadelphia, PA, 19104, USA. brian.anderson@uphs.upenn.edu., Calfee CS; Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, USA., Liu KD; Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, USA., Reilly JP; Division of Pulmonary, Allergy and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 5036 Gates Building, Philadelphia, PA, 19104, USA., Kangelaris KN; Division of Hospital Medicine, Department of Medicine, University of California San Francisco, San Francisco, USA., Shashaty MGS; Division of Pulmonary, Allergy and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 5036 Gates Building, Philadelphia, PA, 19104, USA.; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA., Lazaar AL; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.; GlaxoSmithKline R&D, Brentford, UK., Bayliffe AI; GlaxoSmithKline R&D, Brentford, UK., Gallop RJ; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.; Department of Mathematics, West Chester University, West Chester, USA., Miano TA; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA., Dunn TG; Division of Pulmonary, Allergy and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 5036 Gates Building, Philadelphia, PA, 19104, USA., Johansson E; Division of Pulmonary, Allergy and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 5036 Gates Building, Philadelphia, PA, 19104, USA., Abbott J; Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, USA., Jauregui A; Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, USA., Deiss T; Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, USA., Vessel K; Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, USA., Belzer A; Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, USA., Zhuo H; Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, USA., Matthay MA; Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, USA., Meyer NJ; Division of Pulmonary, Allergy and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 5036 Gates Building, Philadelphia, PA, 19104, USA., Christie JD; Division of Pulmonary, Allergy and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 5036 Gates Building, Philadelphia, PA, 19104, USA.; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.

Publikováno v: Critical care (London, England) [Crit Care] 2019 Dec 09; Vol. 23 (1), pp. 400. Date of Electronic Publication: 2019 Dec 09.

Specificity of human anti-variable heavy (VH ) chain autoantibodies and impact on the design and clinical testing of a VH domain antibody antagonist of tumour necrosis factor-α receptor 1.

Autor: Cordy JC; GlaxoSmithKline, Stevenage, UK., Morley PJ; GlaxoSmithKline, Stevenage, UK., Wright TJ; GlaxoSmithKline, Stevenage, UK., Birchler MA; GlaxoSmithKline, King of Prussia, PA, USA., Lewis AP; GlaxoSmithKline, Stevenage, UK., Emmins R; GlaxoSmithKline, Stevenage, UK., Chen YZ; GlaxoSmithKline, King of Prussia, PA, USA., Powley WM; GlaxoSmithKline, Stevenage, UK., Bareille PJ; GlaxoSmithKline, Stevenage, UK., Wilson R; GlaxoSmithKline, Stevenage, UK., Tonkyn J; GlaxoSmithKline, Stevenage, UK., Bayliffe AI; GlaxoSmithKline, Stevenage, UK., Lazaar AL; GlaxoSmithKline, King of Prussia, PA, USA.

Publikováno v: Clinical and experimental immunology [Clin Exp Immunol] 2015 Nov; Vol. 182 (2), pp. 139-48. Date of Electronic Publication: 2015 Sep 11.

Autoantibodies to variable heavy (VH) chain Ig sequences in humans impact the safety and clinical pharmacology of a VH domain antibody antagonist of TNF-α receptor 1.

Autor: Holland MC; Research and Development, GlaxoSmithKline R&D, 709 Swedeland Road, King of Prussia, PA, 19406, USA., Wurthner JU, Morley PJ, Birchler MA, Lambert J, Albayaty M, Serone AP, Wilson R, Chen Y, Forrest RM, Cordy JC, Lipson DA, Bayliffe AI

Publikováno v: Journal of clinical immunology [J Clin Immunol] 2013 Oct; Vol. 33 (7), pp. 1192-203. Date of Electronic Publication: 2013 Jul 06.