Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Bayard R. Huck"'
Autor:
Brian H. Heasley, Jing Lin, Thomas F. N. Haxell, Igor Mochalkin, Constantin Neagu, Felix Rohdich, Ruoxi Lan, Amanda E. Sutton, Jennifer Jackson, Potnick Justin, Bayard R. Huck, Andreas Machl, Katrin Georgi, Xiaoling Chen, Sherer Brian A, Erik Wilker, Thomas E. Richardson, Anderson Clark, Reinaldo Jones, Johnson Theresa L, Lizbeth Celeste Deselm, Andreas Goutopoulos, Hui Tian, Yufang Xiao, Joseph A. Moore, Lindsey Crowley
Publikováno v:
Journal of Medicinal Chemistry. 64:14603-14619
Herein, we report the discovery of a novel class of quinazoline carboxamides as dual p70S6k/Akt inhibitors for the treatment of tumors driven by alterations to the PI3K/Akt/mTOR (PAM) pathway. Through the screening of in-house proprietary kinase libr
Publikováno v:
Nature Reviews Chemistry. 7:3-4
Autor:
Ruoxi Lan, Hui Tian, Dusica Santos, Lizbeth Celeste Deselm, Jing Lin, Donald Bankston, Constantin Neagu, Sherer Brian A, Jennifer Jackson, Jared Head, Jianguo Ma, Xuliang Jiang, Sakeena Syed, Anderson Clark, Andreas Machl, Yufang Xiao, Erik Wilker, Anna Gardberg, Xiaoling Chen, Igor Mochalkin, Bayard R. Huck, Hui Qiu, Christopher Charles Victor Jones, Vikram Dutt, Johnson Theresa L, Andreas Goutopoulos
Publikováno v:
Bioorganicmedicinal chemistry letters. 50
Activation of the PI3K/Akt/mTOR kinase pathway is associated with human cancers. A dual p70S6K/Akt inhibitor is sufficient to inhibit strong tumor growth and to block negative impact of the compensatory Akt feedback loop activation. A scaffold dockin
Autor:
Yufang Xiao, Bayard R. Huck, Ruoxi Lan, Lizbeth DeSelm, Xiaoling Chen, Hui Qiu, Constantin Neagu, Theresa Johnson, Igor Mochalkin, Anna Gardberg, Xuliang Jiang, Hui Tian, Vikram Dutt, Dusica Santos, Jared Head, Jennifer Jackson, Sakeena Syed, Jing Lin, Erik Wilker, Jianguo Ma, Anderson Clark, Andreas Machl, Donald Bankston, Christopher C.V. Jones, Andreas Goutopoulos, Brian Sherer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 67:128758
Autor:
Dusica Cvetinovic Santos, Klaus Urbahns, Simone C. Zimmerli, Andreas Goutopoulos, Justin R. Potnick, Andrew Bender, Michael Meyring, Adam Shutes, Christopher Charles Victor Jones, Jared Head, Ben C. Askew, Bayard R. Huck, Ansgar Wegener, Hui Qiu, Theresa L. Johnson, Nadia Brugger, Sherer Brian A, Ngan Nguyen, Mohanraj Dhanabal, Ralf Schmidt, Roland Grenningloh, Reinaldo Jones, Richard D. Caldwell, Ariele Viacava Follis, Brian Healey, Montserrat Camps, Igor Mochalkin, Federica Morandi, Lesley Liu-Bujalski, Vikram Dutt, Brian L. Hodous, Anna Gardberg, Thomas Eichhorn
Publikováno v:
Journal of Medicinal Chemistry. 62:7643-7655
Bruton's tyrosine kinase (BTK) inhibitors such as ibrutinib hold a prominent role in the treatment of B cell malignancies. However, further refinement is needed to this class of agents, particularly in terms of adverse events (potentially driven by k
Immuno-oncology therapies are revolutionizing the oncology landscape with checkpoint blockade becoming the treatment backbone for many indications. While inspiring, much work remains to increase the number of cancer patients that can benefit from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0309c749df2c83fff3e7d3758a7eab1
https://doi.org/10.1016/bs.pmch.2019.11.001
https://doi.org/10.1016/bs.pmch.2019.11.001
Publikováno v:
Angewandte Chemie (International Ed. in English)
Immuno‐oncology therapies have the potential to revolutionize the armamentarium of available cancer treatments. To further improve clinical response rates, researchers are looking for novel combination regimens, with checkpoint blockade being used
Publikováno v:
Angewandte Chemie. 130:4499-4516
Autor:
Igor Mochalkin, Bayard R. Huck
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(13)
The frequency of PI3K/Akt/mTOR (PAM) Pathway mutations in human cancers sparked interest to determine if the pathway is druggable. The modest clinical benefit observed with mTOR rapalogs (temsirolimus and everolimus) provided further motivation to id
Autor:
Manja Friese-Hamim, Klaus Duecker, Dirk Wienke, Frank Zenke, Andree Blaukat, Felix Rohdich, Timo Heinrich, Bayard R. Huck, Olga Bogatyrova, Christoph Schultes, Maria J. Ortiz
Publikováno v:
Cancer Research. 79:3075-3075
N-terminal cleavage of methionine by methionine aminopeptidases is a crucial step in the maturation of proteins during protein biosynthesis. MetAP2, one of the two methionine aminopeptidases expressed in mammalian cells, has been identified as the ta