Zobrazeno 1 - 10
of 402
pro vyhledávání: '"Bayard L. Powell"'
Autor:
Scott R. Solomon, Bayard L. Powell, Jamie Koprivnikar, Catherine Lai, Heather Male, Laura C. Michaelis, Laura F. Newell, David Sanford, Jack Jenkins, Amy Zelaya, Sheryl Coppola, Stefan Faderl, Roland B. Walter
Publikováno v:
Cancers, Vol 16, Iss 5, p 915 (2024)
This open-label phase 1 study (clinicaltrials.gov, NCT03555955) assessed CPX-351 pharmacokinetics (PK) and safety in patients with hematologic malignancies with normal or impaired renal function. Patients were enrolled into three cohorts based on the
Externí odkaz:
https://doaj.org/article/a32abb183e3b4fcca91ced09b2af1728
Autor:
Rebecca Anderson, Lance D. Miller, Scott Isom, Jeff W. Chou, Kristin M. Pladna, Nathaniel J. Schramm, Leslie R. Ellis, Dianna S. Howard, Rupali R. Bhave, Megan Manuel, Sarah Dralle, Susan Lyerly, Bayard L. Powell, Timothy S. Pardee
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Combining cytarabine and mitoxantrone with the tricarboxylic acid cycle inhibitor devimistat has been reported in a phase I clinical trial with relapsed or refractory acute myeloid leukaemia (AML). Here, the authors report the outcomes of a phase II
Externí odkaz:
https://doaj.org/article/af7e039587ff405b8de70ccdba887ce2
Autor:
Marius Bill, Krzysztof Mrózek, Brian Giacopelli, Jessica Kohlschmidt, Deedra Nicolet, Dimitrios Papaioannou, Ann-Kathrin Eisfeld, Jonathan E. Kolitz, Bayard L. Powell, Andrew J. Carroll, Richard M. Stone, Ramiro Garzon, John C. Byrd, Clara D. Bloomfield, Christopher C. Oakes
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-4 (2021)
Abstract Recently, a novel knowledge bank (KB) approach to predict outcomes of individual patients with acute myeloid leukemia (AML) was developed using unbiased machine learning. To validate its prognostic value, we analyzed 1612 adults with de novo
Externí odkaz:
https://doaj.org/article/669c5f440b8c44788746a08d60d8109e
Autor:
Alice S. Mims, Jessica Kohlschmidt, Uma Borate, James S. Blachly, Shelley Orwick, Ann-Kathrin Eisfeld, Dimitrios Papaioannou, Deedra Nicolet, Krzysztof Mrόzek, Eytan Stein, Bhavana Bhatnagar, Richard M. Stone, Jonathan E. Kolitz, Eunice S. Wang, Bayard L. Powell, Amy Burd, Ross L. Levine, Brian J. Druker, Clara D. Bloomfield, John C. Byrd
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background Older patients (≥ 60 years) with acute myeloid leukemia (AML) often have multiple, sequentially acquired, somatic mutations that drive leukemogenesis and are associated with poor outcome. Beat AML is a Leukemia and Lymphoma Soci
Externí odkaz:
https://doaj.org/article/c4c6e83a72104dcd8a6a682632819213
Autor:
Liang Liu, Tamjeed Ahmed, William J. Petty, Stefan Grant, Jimmy Ruiz, Thomas W. Lycan, Umit Topaloglu, Ping‐Chieh Chou, Lance D. Miller, Gregory A. Hawkins, Martha A. Alexander‐Miller, Stacey S. O’Neill, Bayard L. Powell, Ralph B. D’Agostino Jr., Reginald F. Munden, Boris Pasche, Wei Zhang
Publikováno v:
Molecular Oncology, Vol 15, Iss 2, Pp 462-472 (2021)
KRAS is a key oncogenic driver in lung adenocarcinoma (LUAD). Chromatin‐remodeling gene SMARCA4 is comutated with KRAS in LUAD; however, the impact of SMARCA4 mutations on clinical outcome has not been adequately established. This study sought to s
Externí odkaz:
https://doaj.org/article/10831ff302a646b0a04a6e47714a2c57
Autor:
Samuel J. Yates, Susan Lyerly, Megan Manuel, Janet A. Tooze, Heidi D. Klepin, Bayard L. Powell, Sarah Dralle, Alok Uprety, Timothy S. Pardee
Publikováno v:
Cancer Medicine, Vol 9, Iss 7, Pp 2403-2413 (2020)
Abstract Standardized phase angle (SPhA) is a tool used to estimate body composition and cell membrane integrity. Standardized phase angle has been shown to predict survival in solid malignancies and hematopoietic stem cell transplant patients. We in
Externí odkaz:
https://doaj.org/article/b87ea54ff8ec472aa131fd5bd10a77ec
Autor:
Dimitrios Papaioannou, Hatice G. Ozer, Deedra Nicolet, Amog P. Urs, Tobias Herold, Krzysztof Mrózek, Aarif M.N. Batcha, Klaus H. Metzeler, Ayse S. Yilmaz, Stefano Volinia, Marius Bill, Jessica Kohlschmidt, Maciej Pietrzak, Christopher J. Walker, Andrew J. Carroll, Jan Braess, Bayard L. Powell, Ann-Kathrin Eisfeld, Geoffrey L. Uy, Eunice S. Wang, Jonathan E. Kolitz, Richard M. Stone, Wolfgang Hiddemann, John C. Byrd, Clara D. Bloomfield, Ramiro Garzon
Publikováno v:
Haematologica, Vol 107, Iss 5 (2021)
Expression levels of long non-coding RNA (lncRNA) have been shown to associate with clinical outcome of patients with cytogenetically normal acute myeloid leukemia (CN-AML). However, the frequency and clinical significance of genetic variants in the
Externí odkaz:
https://doaj.org/article/7f9bf447eead48ccb2195be68f8f7b08
Autor:
Marius Bill, Deedra Nicolet, Jessica Kohlschmidt, Christopher J. Walker, Krzysztof Mrózek, Ann-Kathrin Eisfeld, Dimitrios Papaioannou, Xiaoqing Rong-Mullins, Zachary Brannan, Jonathan E. Kolitz, Bayard L. Powell, Kellie J. Archer, Adrienne M. Dorrance, Andrew J. Carroll, Richard M. Stone, John C. Byrd, Ramiro Garzon, Clara D. Bloomfield
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Leukemia stem cells (LSC) are more resistant to standard chemotherapy and their persistence during remission can cause relapse, which is still one of the major clinical challenges in the treatment of acute myeloid leukemia (AML). A better understandi
Externí odkaz:
https://doaj.org/article/163b6fd50bee4ae78efe618cb9abc265
Autor:
Pierre Fenaux, Aristoteles Giagounidis, Dominik Selleslag, Odile Beyne-Rauzy, Moshe Mittelman, Petra Muus, Stephen D. Nimer, Eva Hellström-Lindberg, Bayard L. Powell, Agnes Guerci-Bresler, Mikkael A. Sekeres, H. Joachim Deeg, Consuelo del Cañizo, Peter L. Greenberg, Jamile M. Shammo, Barry Skikne, Xujie Yu, Alan F. List
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-8 (2017)
Abstract Background Particularly since the advent of lenalidomide, lower-risk myelodysplastic syndromes (MDS) patients with del(5q) have been the focus of many studies; however, the impact of age on disease characteristics and response to lenalidomid
Externí odkaz:
https://doaj.org/article/e33788a17f6a499d88585d724ce72be7
Autor:
Meng Yang, Umit Topaloglu, W. Jeffrey Petty, Matthew Pagni, Kristie L. Foley, Stefan C. Grant, Mac Robinson, Rhonda L. Bitting, Alexandra Thomas, Angela T. Alistar, Rodwige J. Desnoyers, Michael Goodman, Carol Albright, Mercedes Porosnicu, Mihaela Vatca, Shadi A. Qasem, Barry DeYoung, Ville Kytola, Matti Nykter, Kexin Chen, Edward A. Levine, Edgar D. Staren, Ralph B. D’Agostino, Robin M. Petro, William Blackstock, Bayard L. Powell, Edward Abraham, Boris Pasche, Wei Zhang
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-13 (2017)
Abstract Background Solid tumors residing in tissues and organs leave footprints in circulation through circulating tumor cells (CTCs) and circulating tumor DNAs (ctDNA). Characterization of the ctDNA portraits and comparison with tumor DNA mutationa
Externí odkaz:
https://doaj.org/article/27e15bc7a4b548a186dbcfff0a658a65