Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Bayan Aljabari"'
Autor:
Joshua Bloom, Georgios Pantouris, Mingzhu He, Bayan Aljabari, Lopa Mishra, Ramu Manjula, Andrew Parkins, Elias J. Lolis, Yousef Al-Abed
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-11 (2024)
Abstract Background Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in multiple inflammatory and non-inflammatory diseases, including liver injury induced by acetaminophen (APAP) overdose. Multiple smal
Externí odkaz:
https://doaj.org/article/01c465a038f949bca1d406659cc58eaf
Autor:
Sonya VanPatten, Bayan Aljabari, Nathalie Meurice, Kai Fan Cheng, Hans J. Lee, Kevin J. Tracey, Edmund J. Miller, Yousef Al-Abed, Valentin A. Pavlov, Mahendar Ochani, Steven Blau, Thomas Coleman, Christine N. Metz
Publikováno v:
Proceedings of the National Academy of Sciences. 108:8224-8227
Abnormally low plasma concentrations of thyroid hormones during sepsis often occur in the absence of thyroidal illness; however, the mechanisms involved in the “euthyroid sick syndrome” remain poorly understood. Here, we describe a previously unr
Autor:
Julius Popp, Frank Jessen, Frauke Neff, Rupert Egensperger, Michael Bacher, Carmen Noelker, Yousef Al-Abed, Bayan Aljabari, Richard Dodel, Jens P. Reese, Oliver Deuster
Publikováno v:
Molecular Medicine. 16:116-121
Previous studies have shown that amyloid beta protein (Abeta ), the essential molecule for the formation of toxic oligomers and, subsequently, Alzheimer plaques, has been associated in vivo with the immune modulator, macrophage migration inhibitory f
Autor:
Michael Bacher, Rakez Kayed, Anne Marie Hoppmann, Charles G. Glabe, Lars Lewejohann, Susanne Schnell, Philippe Marambaud, Nicole Goertz, Bayan Aljabari, Jens Klotsche, Yousef Al-Abed, Norbert Sachser, Kathy Keyvani, Richard Dodel
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, 2008, Bd. 205, Nr. 7, S. 1593-1599, ISSN: 0022-1007
Journal of Experimental Medicine, 2008, Bd. 205, Nr. 7, S. 1593-1599, ISSN: 0022-1007
Alzheimer's disease (AD) is characterized by neuronal atrophy caused by soluble amyloid beta protein (Abeta) peptide "oligomers" and a microglial-mediated inflammatory response elicited by extensive amyloid deposition in the brain. We show that CNI-1
Autor:
Bayan Aljabari, Valentine A. Pavlov, Gregg V. Crichlow, Kai Fan Cheng, Elias Lolis, Mahendar Ochani, Edmund J. Miller, Yousef Al-Abed, Darrin Dabideen
Publikováno v:
Journal of Biological Chemistry. 282:23089-23095
Pharmacophores are chemical scaffolds upon which changes in chemical moieties (R-groups) at specific sites are made to identify a combination of R-groups that increases the therapeutic potency of a small molecule inhibitor while minimizing adverse ef
Autor:
Valentin A. Pavlov, Yousef Al-Abed, Bayan Aljabari, Kai Fan Cheng, Edmund J. Miller, Darrin Dabideen
Publikováno v:
Journal of Medicinal Chemistry. 50:1993-1997
A series of phenolic hydrazones were synthesized and evaluated for their inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity. Compound 7 emerged as a potent inhibitor of MIF with an IC50 of 130 nM. Compound 7 dose-dependen
Autor:
David J.E. Callaway, Richard Bucala, Einar M. Sigurdsson, Christine N. Metz, Bayan Aljabari, Hilal A. Lashuel, Lin Leng
Publikováno v:
Biochemical and Biophysical Research Communications. 338:973-980
We demonstrate herein that human macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine expressed in the brain and not previously considered to be amyloidogenic, forms amyloid fibrils similar to those derived from the disease assoc
Autor:
Rakez Kayed, Yousef Al-Abed, Lars Lewejohann, Richard Dodel, Philippe Marambaud, Michael Bacher, Nicole Goertz, Charles G. Glabe, Bayan Aljabari, Jens Klotsche, Norbert Sachser, Kathy Keyvani
Publikováno v:
Alzheimer's & Dementia. 4
Autor:
Richard Dodel, Michael Bacher, Bayan Aljabari, Susanne Schnell, Oliver Deuster, Yousef Al-Abed, Carmen Noelker
Publikováno v:
Alzheimer's & Dementia. 2
Autor:
Susanne Schnell, Kathy Keyvani, Rakez Kayed, Charles G. Glabe, Richard Dodel, Michael Bacher, Yousef Al-Abed, Bayan Aljabari, Nicole Goertz, Philippe Marambaud
Publikováno v:
Alzheimer's & Dementia. 2