Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum.

Autor: Venkatesh SS; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Wittemans LBL; Novo Nordisk Research Centre Oxford, Oxford, United Kingdom.; Nuffield Department of Women's and Reproductive Health, Medical Sciences Division, University of Oxford, United Kingdom., Palmer DS; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom., Baya NA; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Ferreira T; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom., Hill B; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom., Lassen FH; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Parker MJ; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom., Reibe S; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom., Elhakeem A; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Banasik K; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.; Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark., Bruun MT; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark., Jensen BA; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Juul A; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; Copenhagen, Denmark.; Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Mikkelsen C; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, Copenhagen University, Copenhagen, Denmark., Nielsen HS; Department of Obstetrics and Gynecology, The Fertility Clinic, Hvidovre University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen OB; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Kge, Denmark., Rohde PD; Genomic Medicine, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Sorensen E; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Westergaard D; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.; Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark., Haraldsson A; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Children's Hospital Iceland, Landspitali University Hospital, Reykjavik, Iceland., Holm H; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Jonsdottir I; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Olafsson I; Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland., Steingrimsdottir T; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, Iceland., Steinthorsdottir V; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Thorleifsson G; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Figueredo J; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Karjalainen MK; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Finland.; Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland., Pasanen A; Research Unit of Clinical Medicine, Medical Research Center Oulu, University of Oulu, and Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland., Jacobs BM; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University London, London, EC1M 6BQ, United Kingdom., Hubers N; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Institute, Amsterdam, The Netherlands., Lippincott M; Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Fraser A; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Lawlor DA; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Timpson NJ; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Nyegaard M; Genomic Medicine, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Stefansson K; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Magi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Laivuori H; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Obstetrics and Gynecology, Tampere University Hospital, Finland.; Center for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Finland., van Heel DA; Blizard Institute, Queen Mary University London, London, E1 2AT, United Kingdom., Boomsma DI; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Institute, Amsterdam, The Netherlands., Balasubramanian R; Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Seminara SB; Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Chan YM; Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, United States of America., Laisk T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Lindgren CM; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.; Nuffield Department of Women's and Reproductive Health, Medical Sciences Division, University of Oxford, United Kingdom.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Mar 20. Date of Electronic Publication: 2024 Mar 20.

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