A comparison of intervertebral ligament properties utilized in a thoracic spine functional unit through kinematic evaluation.

Autor: Polanco M; Mechanical and Aerospace Engineering Department, Old Dominion University, Norfolk, VA, USA., Ringleb S; Mechanical and Aerospace Engineering Department, Old Dominion University, Norfolk, VA, USA., Audette M; Computational Modeling and Simulation Engineering, Old Dominion University, Norfolk, VA, USA., Kakar R; School of Health Sciences, Oakland University, Rochester, MI, USA., Bawab S; Mechanical and Aerospace Engineering Department, Old Dominion University, Norfolk, VA, USA.

Publikováno v: Computer methods in biomechanics and biomedical engineering [Comput Methods Biomech Biomed Engin] 2023 Sep; Vol. 26 (11), pp. 1330-1340. Date of Electronic Publication: 2022 Sep 15.

Translational PK/PD Modeling of Tumor Growth Inhibition and Target Inhibition to Support Dose Range Selection of the LMP7 Inhibitor M3258 in Relapsed/Refractory Multiple Myeloma.

Autor: Lignet F; The Healthcare Business of Merck KGaA, Darmstadt, Germany (F.L., C.E., G.W.-B., M.F.-H., S.S., S.E.B., A.D.B., C.G., M.P.S., F.R.) and EMD Serono, Billerica, Massachusetts (E.D.) floriane.lignet@merckgroup.com., Esdar C; The Healthcare Business of Merck KGaA, Darmstadt, Germany (F.L., C.E., G.W.-B., M.F.-H., S.S., S.E.B., A.D.B., C.G., M.P.S., F.R.) and EMD Serono, Billerica, Massachusetts (E.D.)., Walter-Bausch G; The Healthcare Business of Merck KGaA, Darmstadt, Germany (F.L., C.E., G.W.-B., M.F.-H., S.S., S.E.B., A.D.B., C.G., M.P.S., F.R.) and EMD Serono, Billerica, Massachusetts (E.D.)., Friese-Hamim M; The Healthcare Business of Merck KGaA, Darmstadt, Germany (F.L., C.E., G.W.-B., M.F.-H., S.S., S.E.B., A.D.B., C.G., M.P.S., F.R.) and EMD Serono, Billerica, Massachusetts (E.D.)., Stinchi S; The Healthcare Business of Merck KGaA, Darmstadt, Germany (F.L., C.E., G.W.-B., M.F.-H., S.S., S.E.B., A.D.B., C.G., M.P.S., F.R.) and EMD Serono, Billerica, Massachusetts (E.D.)., Drouin E; The Healthcare Business of Merck KGaA, Darmstadt, Germany (F.L., C.E., G.W.-B., M.F.-H., S.S., S.E.B., A.D.B., C.G., M.P.S., F.R.) and EMD Serono, Billerica, Massachusetts (E.D.)., El Bawab S; The Healthcare Business of Merck KGaA, Darmstadt, Germany (F.L., C.E., G.W.-B., M.F.-H., S.S., S.E.B., A.D.B., C.G., M.P.S., F.R.) and EMD Serono, Billerica, Massachusetts (E.D.)., Becker AD; The Healthcare Business of Merck KGaA, Darmstadt, Germany (F.L., C.E., G.W.-B., M.F.-H., S.S., S.E.B., A.D.B., C.G., M.P.S., F.R.) and EMD Serono, Billerica, Massachusetts (E.D.)., Gimmi C; The Healthcare Business of Merck KGaA, Darmstadt, Germany (F.L., C.E., G.W.-B., M.F.-H., S.S., S.E.B., A.D.B., C.G., M.P.S., F.R.) and EMD Serono, Billerica, Massachusetts (E.D.)., Sanderson MP; The Healthcare Business of Merck KGaA, Darmstadt, Germany (F.L., C.E., G.W.-B., M.F.-H., S.S., S.E.B., A.D.B., C.G., M.P.S., F.R.) and EMD Serono, Billerica, Massachusetts (E.D.)., Rohdich F; The Healthcare Business of Merck KGaA, Darmstadt, Germany (F.L., C.E., G.W.-B., M.F.-H., S.S., S.E.B., A.D.B., C.G., M.P.S., F.R.) and EMD Serono, Billerica, Massachusetts (E.D.).

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2023 Jan; Vol. 384 (1), pp. 163-172. Date of Electronic Publication: 2022 Oct 23.

Using thrombocytopenia modeling to investigate the mechanisms underlying platelet depletion induced by pan-proteasome inhibitors.

Autor: Lignet F; Translational Medicine, Quantitative Pharmacology, The Healthcare Business of Merck KGaA, Darmstadt, Germany., Becker AD; Translational Medicine, Quantitative Pharmacology, The Healthcare Business of Merck KGaA, Darmstadt, Germany., Gimmi C; Global Clinical Development Oncology, The Healthcare Business of Merck KGaA, Darmstadt, Germany., Rohdich F; Discovery Technology, Drug Metabolism and Pharmacokinetics, The Healthcare Business of Merck KGaA, Darmstadt, Germany., El Bawab S; Translational Medicine, Quantitative Pharmacology, The Healthcare Business of Merck KGaA, Darmstadt, Germany.

Publikováno v: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2022 May; Vol. 11 (5), pp. 594-603. Date of Electronic Publication: 2021 Nov 29.

Model‐Based Evaluation of Radiation and Radiosensitizing Agents in Oncology

Autor: Cardilin, T., Almquist, J., Jirstrand, M., Zimmermann, A., Bawab, S. El, Gabrielsson, J.

Radiotherapy is one of the major therapy forms in oncology, and combination therapies involving radiation and chemical compounds can yield highly effective tumor eradication. In this paper, we develop a tumor growth inhibition model for combination t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::9dbbc72a4e729c2a5562956f9fa04499
https://publica.fraunhofer.de/handle/publica/261985

Cocaine-Induced DNA-Dependent Protein Kinase Relieves RNAP II Pausing by Promoting TRIM28 Phosphorylation and RNAP II Hyperphosphorylation to Enhance HIV Transcription.

Autor: Sharma, Adhikarimayum Lakhikumar¹ (AUTHOR) lakhikumarsharma.adhikarimayum@jefferson.edu, Tyagi, Priya¹ (AUTHOR), Khumallambam, Meenata¹ (AUTHOR), Tyagi, Mudit¹ (AUTHOR) mudit.tyagi@jefferson.edu

Publikováno v: Cells (2073-4409). Dec2024, Vol. 13 Issue 23, p1950. 36p.