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Glycation products in aged thioglycollate medium enhance the elicitation of peritoneal macrophages

Autor: Li, Y. M., Baviello, G., Vlassara, H., Mitsuhashi, T.

Publikováno v: Journal of Immunological Methods; 1997, Vol. 201 Issue: 2 p183-188, 6p

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Protein Engineering on Human Recombinant Follistatin: Enhancing Pharmacokinetic Characteristics for Therapeutic Application.

Autor: Shen C; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Iskenderian A; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Lundberg D; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., He T; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Palmieri K; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Crooker R; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Deng Q; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Traylor M; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Gu S; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Rong H; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Ehmann D; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Pescatore B; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Strack-Logue B; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Romashko A; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Baviello G; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Gill J; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Zhang B; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Meiyappan M; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Pan C; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.)., Norton AW; Departments of Discovery Therapeutics (C.S., A.I., D.L., B.P., B.S.-L., A.R., G.B., J.G., B.Z., M.M., C.P., A.W.N.), Bioanalytical and Biomarker Development (T.H.), Discovery Biology and Translational Research (K.P., R.C., Q.D., D.E.), Analytical Development (M.T., S.G.), and Drug Metabolism and Pharmacokinetics (H.R.), Shire, Lexington, Massachusetts (H.R.) anorton@shire.com.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2018 Aug; Vol. 366 (2), pp. 291-302. Date of Electronic Publication: 2018 May 11.