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Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach.

Autor: Mansouri M; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Rumrill S; Center for Advanced Biotechnology and Medicine, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA., Dawson S; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Johnson A; Retroviral Biology and Antivirals Laboratory, Disease Elimination Program, Life Sciences Discipline, Burnet Institute, Melbourne, VIC 3004, Australia., Pinson JA; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Gunzburg MJ; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Latham CF; Retroviral Biology and Antivirals Laboratory, Disease Elimination Program, Life Sciences Discipline, Burnet Institute, Melbourne, VIC 3004, Australia., Barlow N; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Mbogo GW; Retroviral Biology and Antivirals Laboratory, Disease Elimination Program, Life Sciences Discipline, Burnet Institute, Melbourne, VIC 3004, Australia., Ellenberg P; Retroviral Biology and Antivirals Laboratory, Disease Elimination Program, Life Sciences Discipline, Burnet Institute, Melbourne, VIC 3004, Australia., Headey SJ; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Sluis-Cremer N; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Tyssen D; Retroviral Biology and Antivirals Laboratory, Disease Elimination Program, Life Sciences Discipline, Burnet Institute, Melbourne, VIC 3004, Australia., Bauman JD; Center for Advanced Biotechnology and Medicine, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA., Ruiz FX; Center for Advanced Biotechnology and Medicine, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA., Arnold E; Center for Advanced Biotechnology and Medicine, Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA., Chalmers DK; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia., Tachedjian G; Retroviral Biology and Antivirals Laboratory, Disease Elimination Program, Life Sciences Discipline, Burnet Institute, Melbourne, VIC 3004, Australia.; Department of Microbiology, Monash University, Clayton, VIC 3168, Australia.; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC 3000, Australia.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Mar 30; Vol. 28 (7). Date of Electronic Publication: 2023 Mar 30.

Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT).

Autor: Harrison JJEK; Center for Advanced Biotechnology and Medicine (CABM), Rutgers University, Piscataway, NJ 08854, USA.; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.; Department of Chemistry, University of Ghana, Legon P.O. Box LG 56, Ghana., Tuske S; Center for Advanced Biotechnology and Medicine (CABM), Rutgers University, Piscataway, NJ 08854, USA., Das K; Center for Advanced Biotechnology and Medicine (CABM), Rutgers University, Piscataway, NJ 08854, USA.; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium., Ruiz FX; Center for Advanced Biotechnology and Medicine (CABM), Rutgers University, Piscataway, NJ 08854, USA., Bauman JD; Center for Advanced Biotechnology and Medicine (CABM), Rutgers University, Piscataway, NJ 08854, USA., Boyer PL; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702, USA., DeStefano JJ; Department of Cell Biology and Molecular Genetics, University of Maryland College Park, College Park, MD 20742, USA., Hughes SH; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702, USA., Arnold E; Center for Advanced Biotechnology and Medicine (CABM), Rutgers University, Piscataway, NJ 08854, USA.; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.

Publikováno v: Viruses [Viruses] 2021 Jul 29; Vol. 13 (8). Date of Electronic Publication: 2021 Jul 29.

Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease.

Autor: Sagong HY; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ, 08854-8020, USA., Bauman JD; Center for Advanced Biotechnology and Medicine, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Hoes Lane, Piscataway, NJ, 08854-5627, USA., Nogales A; Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY, 14642, USA., Martínez-Sobrido L; Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY, 14642, USA., Arnold E; Center for Advanced Biotechnology and Medicine, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Hoes Lane, Piscataway, NJ, 08854-5627, USA., LaVoie EJ; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ, 08854-8020, USA.

Publikováno v: ChemMedChem [ChemMedChem] 2019 Jun 18; Vol. 14 (12), pp. 1204-1223. Date of Electronic Publication: 2019 May 14.

A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.

Autor: Patel D; From the Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854., Antwi J; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy and., Koneru PC; Center for Retrovirus Research and College of Pharmacy, Ohio State University, Columbus, Ohio 43210., Serrao E; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215., Forli S; Molecular Graphics Laboratory, Department of Integrative Structural and Computational Biology, MB-112, The Scripps Research Institute, La Jolla, California 92037., Kessl JJ; Department of Chemistry and Biochemistry, University of Southern Mississippi, Hattiesburg, Mississippi 39406, and., Feng L; Center for Retrovirus Research and College of Pharmacy, Ohio State University, Columbus, Ohio 43210., Deng N; Center for Biophysics and Computational Biology, Temple University, Philadelphia, Pennsylvania 19122., Levy RM; Center for Biophysics and Computational Biology, Temple University, Philadelphia, Pennsylvania 19122., Fuchs JR; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy and., Olson AJ; Molecular Graphics Laboratory, Department of Integrative Structural and Computational Biology, MB-112, The Scripps Research Institute, La Jolla, California 92037., Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215., Bauman JD; From the Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854., Kvaratskhelia M; Center for Retrovirus Research and College of Pharmacy, Ohio State University, Columbus, Ohio 43210, kvaratskhelia.1@osu.edu., Arnold E; From the Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey 08854, arnold@cabm.rutgers.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2016 Nov 04; Vol. 291 (45), pp. 23569-23577. Date of Electronic Publication: 2016 Sep 19.