Discovery and preclinical characterization of novel small molecule TRK and ROS1 tyrosine kinase inhibitors for the treatment of cancer and inflammation.

Autor: Narayanan R; Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America., Yepuru M; Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America., Coss CC; Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America., Wu Z; Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America., Bauler MN; Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America., Barrett CM; Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America., Mohler ML; Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America., Wang Y; Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America., Kim J; Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America., Snyder LM; Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America., He Y; Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America., Levy N; Chembridge Research Laboratory, San Diego, California, United States of America., Miller DD; Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America., Dalton JT; Preclinical Research and Development, GTx, Inc., Memphis, Tennessee, United States of America.

Publikováno v: PloS one [PLoS One] 2013 Dec 26; Vol. 8 (12), pp. e83380. Date of Electronic Publication: 2013 Dec 26 (Print Publication: 2013).

GTx-822, an ER{beta}-selective agonist, protects retinal pigment epithelium (ARPE-19) from oxidative stress by activating MAPK and PI3-K pathways.

Autor: Giddabasappa A; Preclinical Research and Development, GTx, Inc, Memphis, Tennessee 38163, USA., Bauler MN, Barrett CM, Coss CC, Wu Z, Miller DD, Dalton JT, Eswaraka JR

Publikováno v: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2010 Nov; Vol. 51 (11), pp. 5934-42. Date of Electronic Publication: 2010 Jun 16.