The Role of Tryptophan in π Interactions in Proteins: An Experimental Approach

Autor: Jinfeng Shao, Bastiaan P. Kuiper, Andy-Mark W. H. Thunnissen, Robbert H. Cool, Liang Zhou, Chenxi Huang, Bauke W. Dijkstra, Jaap Broos

Publikováno v: Journal of the American Chemical Society, 144(30):04986, 13815-13822. AMER CHEMICAL SOC
Journal of the American Chemical Society 144(30), 13815-13822 (2022). doi:10.1021/jacs.2c04986

Journal of the American Chemical Society 144(30), 13815 - 13822 (2022). doi:10.1021/jacs.2c04986
In proteins, the amino acids Phe, Tyr, and especially Trp are frequently involved in π interactions such as $π–π$, cation−$π$, and CH−$π$

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dffa154ce31011240397343ae48b1d6
https://doi.org/10.1021/jacs.2c04986

Structural basis of product inhibition by arabinose and xylose of the thermostable GH43 β-1,4-xylosidase from Geobacillus thermoleovorans IT-08.

Autor: Ali Rohman, Niels van Oosterwijk, Ni Nyoman Tri Puspaningsih, Bauke W Dijkstra

Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0196358 (2018)

Complete degradation of the xylan backbone of hemicellulosic plant cell walls requires the synergistic action of endo-xylanases and β-1,4-xylosidases. While endo-xylanases produce xylooligosaccharides from xylan, β-1,4-xylosidases degrade the xyloo

Externí odkaz: https://doaj.org/article/a7c8aada56604eda8651d5adca95b417

Large-Scale Recombinant Expression and Purification of Human Tyrosinase Suitable for Structural Studies.

Autor: Xuelei Lai, Montserrat Soler-Lopez, Harry J Wichers, Bauke W Dijkstra

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0161697 (2016)

Human tyrosinase (TYR) is a glycoprotein that initiates the first two reactions in the melanin biosynthesis pathway. Mutations in its encoding gene cause Oculocutaneous Albinism type I (OCA1), the most severe form of albinism, which is a group of aut

Externí odkaz: https://doaj.org/article/d883a70252c3468b8ca3bcd3cc847197

Thalamic morphology predicts the onset of freezing of gait in Parkinson’s disease

Autor: Alice Nieuwboer, Sima Chalavi, Griet Vervoort, Moran Gilat, Nicholas D'Cruz, Bauke W Dijkstra

Publikováno v: npj Parkinsons Disease
NPJ Parkinson's Disease
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-10 (2021)

The onset of freezing of gait (FOG) in Parkinson’s disease (PD) is a critical milestone, marked by a higher risk of falls and reduced quality of life. FOG is associated with alterations in subcortical neural circuits, yet no study has assessed whet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6f07f9fc985c15579a0be10ded3641

AcmD, a homolog of the major autolysin AcmA of Lactococcus lactis, binds to the cell wall and contributes to cell separation and autolysis.

Autor: Ganesh Ram R Visweswaran, Anton Steen, Kees Leenhouts, Monika Szeliga, Beata Ruban, Anne Hesseling-Meinders, Bauke W Dijkstra, Oscar P Kuipers, Jan Kok, Girbe Buist

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e72167 (2013)

Lactococcus lactis expresses the homologous glucosaminidases AcmB, AcmC, AcmA and AcmD. The latter two have three C-terminal LysM repeats for peptidoglycan binding. AcmD has much shorter intervening sequences separating the LysM repeats and a lower i

Externí odkaz: https://doaj.org/article/b4f2e91eb7c441ce81e320403dbf1b8e