Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Bauke V. Schomakers"'
Autor:
Weisha Li, Rebecca L. McIntyre, Bauke V. Schomakers, Rashmi Kamble, Anne H.G. Luesink, Michel van Weeghel, Riekelt H. Houtkooper, Arwen W. Gao, Georges E. Janssens
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109949- (2024)
Summary: As the global aging population rises, finding effective interventions to improve aging health is crucial. Drug repurposing, utilizing existing drugs for new purposes, presents a promising strategy for rapid implementation. We explored naltre
Externí odkaz:
https://doaj.org/article/71f17d80276646c883e60bcbc8f5ad53
Autor:
Brent Appelman, Braeden T. Charlton, Richie P. Goulding, Tom J. Kerkhoff, Ellen A. Breedveld, Wendy Noort, Carla Offringa, Frank W. Bloemers, Michel van Weeghel, Bauke V. Schomakers, Pedro Coelho, Jelle J. Posthuma, Eleonora Aronica, W. Joost Wiersinga, Michèle van Vugt, Rob C. I. Wüst
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months after infection. A distinctive symptom of patients with long COVID is post-exertional malaise, which is associated with a worsening of fatigue- and pain-rel
Externí odkaz:
https://doaj.org/article/eb3db836326a4e81b613e530571f73b5
Autor:
Karl J. Harber, Annette E. Neele, Cindy PAA. van Roomen, Marion JJ. Gijbels, Linda Beckers, Myrthe den Toom, Bauke V. Schomakers, Daan AF. Heister, Lisa Willemsen, Guillermo R. Griffith, Kyra E. de Goede, Xanthe AMH. van Dierendonck, Myrthe E. Reiche, Aurélie Poli, Frida L-H Mogensen, Alessandro Michelucci, Sanne GS. Verberk, Helga de Vries, Michel van Weeghel, Jan Van den Bossche, Menno PJ. de Winther
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103054- (2024)
Inflammatory macrophages are key drivers of atherosclerosis that can induce rupture-prone vulnerable plaques. Skewing the plaque macrophage population towards a more protective phenotype and reducing the occurrence of clinical events is thought to be
Externí odkaz:
https://doaj.org/article/7cec2f81eb784b929ea89dd94752aa37
Autor:
Alex R. Schuurman, Joe M. Butler, Erik H.A. Michels, Natasja A. Otto, Xanthe Brands, Bastiaan W. Haak, Fabrice Uhel, Augustijn M. Klarenbeek, Daniël R. Faber, Bauke V. Schomakers, Michel van Weeghel, Alex F. de Vos, Brendon P. Scicluna, Riekelt H. Houtkooper, W. Joost Wiersinga, Tom van der Poll
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107181- (2023)
Summary: Neutrophils are potent immune cells with key antimicrobial functions. Previous in vitro work has shown that neutrophil effector functions are mainly fueled by intracellular glycolysis. Little is known about the state of neutrophils still in
Externí odkaz:
https://doaj.org/article/4e949718e4164c9fb99adf50b5dffd0d
Autor:
Rebecca L. McIntyre, Marte Molenaars, Bauke V. Schomakers, Arwen W. Gao, Rashmi Kamble, Aldo Jongejan, Michel van Weeghel, André B.P. van Kuilenburg, Richard Possemato, Riekelt H. Houtkooper, Georges E. Janssens
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111928- (2023)
Summary: The human population is aging, and the need for interventions to slow progression of age-related diseases (geroprotective interventions) is growing. Repurposing compounds already used clinically, usually at modified doses, allows rapid imple
Externí odkaz:
https://doaj.org/article/a500213dab204e5bbc1eb68838e73572
Autor:
Bauke V. Schomakers, Jill Hermans, Yorrick R.J. Jaspers, Gajja Salomons, Frédéric M. Vaz, Michel van Weeghel, Riekelt H. Houtkooper
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101302- (2022)
Summary: We describe here a user-friendly analysis protocol for semi-targeted polar metabolomics in human muscle biopsies using Zwitterionic Hydrophilic Interaction Liquid Chromatography and high-resolution full-scan mass spectrometry. Previously, th
Externí odkaz:
https://doaj.org/article/b012603abf2f468bbbd4e563e6efedad
Autor:
Zhenghao Chen, Helga Simon-Molas, Gaspard Cretenet, Beatriz Valle-Argos, Lindsay D. Smith, Francesco Forconi, Bauke V. Schomakers, Michel van Weeghel, Dean J. Bryant, Jaco A. C. van Bruggen, Fleur S. Peters, Jeffrey C. Rathmell, Gerritje J. W. van der Windt, Arnon P. Kater, Graham Packham, Eric Eldering
Publikováno v:
Blood, 140(6), 630-643. American Society of Hematology
Chen, Z, Simon-Molas, H, Cretenet, G, Valle-Argos, B, Smith, L D, Forconi, F, Schomakers, B V, van Weeghel, M, Bryant, D J, van Bruggen, J A C, Peters, F S, Rathmell, J C, van der Windt, G J W, Kater, A P, Packham, G & Eldering, E 2022, ' Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment ', Blood, vol. 140, no. 6, pp. 630-643 . https://doi.org/10.1182/blood.2021013990
Chen, Z, Simon-Molas, H, Cretenet, G, Valle-Argos, B, Smith, L D, Forconi, F, Schomakers, B V, van Weeghel, M, Bryant, D J, van Bruggen, J A C, Peters, F S, Rathmell, J C, van der Windt, G J W, Kater, A P, Packham, G & Eldering, E 2022, ' Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment ', Blood, vol. 140, no. 6, pp. 630-643 . https://doi.org/10.1182/blood.2021013990
Altered metabolism is a hallmark of both cell division and cancer. Chronic lymphocytic leukemia (CLL) cells circulate between peripheral blood (PB) and lymph nodes (LNs), where they receive proliferative and prosurvival signals from surrounding cells
Autor:
Georges E. Janssens, Lotte Grevendonk, Bauke V. Schomakers, Ruben Zapata Perez, Michel van Weeghel, Patrick Schrauwen, Joris Hoeks, Riekelt H. Houtkooper
Publikováno v:
Geroscience. Springer International Publishing AG
Abstract The degenerative processes that occur during aging increase the risk of disease and impaired health. Meanwhile, interventions that target aging to promote healthy longevity are gaining interest, both academically and in the public. While nut
Autor:
Rubén Zapata-Pérez, Antonio Ginés García-Saura, Angelique M.L. Scantlebery, Bauke V. Schomakers, Rubén Rabadán-Ros, Michel van Weeghel, Riekelt H. Houtkooper, Álvaro Sánchez-Ferrer
Publikováno v:
Food Research International, 165:112560. Elsevier Ltd
Dysregulation of nicotinamide adenine dinucleotide (NAD+) homeostasis by increased activity of NAD+ consumers or reduced NAD+ biosynthesis plays an important role in the onset of prevalent, often age-related, diseases, such as diabetes, neuropathies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6647ea2ca9584a84607757b0ce0eee
https://pure.amc.nl/en/publications/biotechnological-production-of-reduced-and-oxidized-nad-precursors(2e10bfaf-7eae-421b-b5cb-db79427c8322).html
https://pure.amc.nl/en/publications/biotechnological-production-of-reduced-and-oxidized-nad-precursors(2e10bfaf-7eae-421b-b5cb-db79427c8322).html
Autor:
Myrthe A.J. Smits, Bauke V. Schomakers, Michel van Weeghel, Eric J.M. Wever, Rob C.I. Wüst, Frederike Dijk, Georges E. Janssens, Mariëtte Goddijn, Sebastiaan Mastenbroek, Riekelt H. Houtkooper, Geert Hamer
Human ovarian ageing encompasses the age-related decline in female fertility. Oxidative stress and mitochondrial dysfunction in oocytes are suggested as causal, but corroborating evidence is limited. Using immunofluorescence imaging on human ovarian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bc20d23d29f820acc879e82fd718e04
https://doi.org/10.1101/2023.01.31.525662
https://doi.org/10.1101/2023.01.31.525662