Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Bauke Schievink"'
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108722 (2014)
There is discussion whether medicines can be authorized on the market based on evidence from surrogate endpoints. We assessed opinions of different stakeholders on this topic.We conducted an online questionnaire that targeted various stakeholder grou
Externí odkaz:
https://doaj.org/article/dac91dee390d420ea9acbc1932019aae
Publikováno v:
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 24(6):492-497
Purpose of review There is increased interest in developing surrogate endpoints for clinical trials of chronic kidney disease progression, as the established clinically meaningful endpoint end-stage renal disease requires large and lengthy trials to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7dd9d81bec6351a0e6314acd41ff9a
https://doi.org/10.1097/mnh.0000000000000159
https://doi.org/10.1097/mnh.0000000000000159
Publikováno v:
British Journal of Clinical Pharmacology. 80:678-686
AimsAngiotensin receptor blockers (ARBs) are renoprotective and targeted to blood pressure. However, ARBs have multiple other (off-target) effects which may affect renal outcome. It is unknown whether on-target and off-target effects are congruent wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1c65444dda0e5daf79e934c64d6f5be
https://doi.org/10.1111/bcp.12655
https://doi.org/10.1111/bcp.12655
Autor:
Viktoriia Starokozhko, Bauke Schievink, Marjolijn T. Merema, Anders Aspegren, Suresh Vatakuti, Geny M. M. Groothuis, Jane Synnergren, Annika Asplund
Publikováno v:
Archives of toxicology, 91(5), 2079-2092. SPRINGER HEIDELBERG
Archives of Toxicology
Archives of Toxicology
Human precision-cut liver slices (hPCLS) are a valuable ex vivo model that can be used in acute toxicity studies. However, a rapid decline in metabolic enzyme activity limits their use in studies that require a prolonged xenobiotic exposure. The aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2587a07ef192be927deb639f8d08e5f
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-13046
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-13046
Autor:
Pepijn Vemer, G. Remuzzi, Dick de Zeeuw, H. J. Lambers Heerspink, Bauke Schievink, H. H. Parving, Jamie P. Dwyer, Tobias F. Kröpelin, Skander Mulder
Publikováno v:
Diabetes obesity & metabolism, 18(1), 64-71. Wiley
To develop and validate a model to simulate progression of diabetic kidney disease (DKD) from early onset until end-stage renal disease (ESRD), and to assess the effect of renin-angiotensin system (RAS) intervention in early, intermediate and advance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b3da8b8bbe1e61a84c852cf366ee4e
https://pubmed.ncbi.nlm.nih.gov/26434564
https://pubmed.ncbi.nlm.nih.gov/26434564
Autor:
Viktoriia Starokozhko, Suresh Vatakuti, Bauke Schievink, Marjolijn T. Merema, Annika Asplund, Jane Synnergren, Anders Aspegren, Geny M. M. Groothuis
Publikováno v:
Archives of Toxicology. 91:2711-2711
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f9ff4f2a25102abe3d6b65bd0caeda
https://doi.org/10.1007/s00204-016-1895-4
https://doi.org/10.1007/s00204-016-1895-4