An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression

Autor: Cano-Gamez, E, Burnham, KL, Goh, C, Allcock, A, Malick, ZH, Overend, L, Kwok, A, Smith, DA, Peters-Sengers, H, Antcliffe, D, GAinS Investigators, McKechnie, S, Scicluna, BP, Van der Poll, T, Gordon, AC, Hinds, CJ, Davenport, EE, Knight, JC, Webster, N, Galley, H, Taylor, J, Hall, S, Addison, J, Roughton, S, Tennant, H, Guleri, A, Waddington, N, Arawwawala, D, Durcan, J, Short, A, Swan, K, Williams, S, Smolen, S, Mitchell-Inwang, C, Gordon, T, Errington, E, Templeton, M, Venatesh, P, Ward, G, McCauley, M, Baudouin, S, Higham, C, Soar, J, Grier, S, Hall, E, Brett, S, Kitson, D, Wilson, R, Mountford, L, Moreno, J, Hall, P, Hewlett, J, Garrard, C, Millo, J, Young, D, Hutton, P, Parsons, P, Smiths, A, Faras-Arraya, R, Raymode, P, Thompson, J, Bowrey, S, Kazembe, S, Rich, N, Andreou, P, Hales, D, Roberts, E, Fletcher, S, Rosbergen, M, Glister, G, Cuesta, JM, Bion, J, Millar, J, Perry, EJ, Willis, H, Mitchell, N, Ruel, S, Carrera, R, Wilde, J, Nilson, A, Lees, S, Kapila, A, Jacques, N, Atkinson, J, Brown, A, Prowse, H, Krige, A, Bland, M, Bullock, L, Harrison, D, Mills, G, Humphreys, J, Armitage, K, Laha, S, Baldwin, J, Walsh, A, Doherty, N, Drage, S, Ortiz-Ruiz de Gordoa, L, Lowes, S, Walsh, H, Calder, V, Swan, C, Payne, H, Higgins, D, Andrews, S, Mappleback, S, Hind, C, Watson, D, McLees, E, Purdy, A, Stotz, M, Ochelli-Okpue, A, Bonner, S, Whitehead, I, Hugil, K, Goodridge, V, Cawthor, L, Kuper, M, Pahary, S, Bellingan, G, Marshall, R, Montgomery, H, Ryu, JH, Bercades, G, Boluda, S, Bentley, A, Mccalman, K, Jefferies, F, Knight, J, Davenport, E, Burnham, K, Maugeri, N, Radhakrishnan, J, Mi, Y

Publikováno v: Science translational medicine, 14(669):eabq4433. American Association for the Advancement of Science

Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1e93e689435401be54b99ae67bfdb7
https://doi.org/10.1126/scitranslmed.abq4433

GluK2 Is a Target for Gene Therapy in Drug-Resistant Temporal Lobe Epilepsy.

Autor: Boileau C; Aix-Marseille Univ. INSERM, Marseille, France., Deforges S; Univ. Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience IINS, UMR 5297, Bordeaux, France., Peret A; Aix-Marseille Univ. INSERM, Marseille, France., Scavarda D; APHM, INSERM, Aix Marseille Univ, INS, Timone Hospital, Pediatric Neurosurgery, Marseille, France., Bartolomei F; APHM, INSERM, Aix Marseille Univ, INS, Timone Hospital, Epileptology Department, Marseille, France., Giles A; REGENXBIO, Rockville, MD, USA., Partouche N; Aix-Marseille Univ. INSERM, Marseille, France.; Corlieve Therapeutics SAS, uniQure NV, Paris, France., Gautron J; Univ. Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience IINS, UMR 5297, Bordeaux, France.; Corlieve Therapeutics SAS, uniQure NV, Paris, France., Viotti J; Univ. Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience IINS, UMR 5297, Bordeaux, France., Janowitz H; REGENXBIO, Rockville, MD, USA., Penchet G; Pellegrin Hospital, Neurosurgery Department, Bordeaux, France., Marchal C; Pellegrin Hospital, Neurosurgery Department, Bordeaux, France., Lagarde S; APHM, INSERM, Aix Marseille Univ, INS, Timone Hospital, Epileptology Department, Marseille, France., Trebuchon A; APHM, INSERM, Aix Marseille Univ, INS, Timone Hospital, Epileptology Department, Marseille, France., Villeneuve N; APHM, INSERM, Aix Marseille Univ, INS, Timone Hospital, Epileptology Department, Marseille, France., Rumi J; Univ. Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience IINS, UMR 5297, Bordeaux, France., Marissal T; Aix-Marseille Univ. INSERM, Marseille, France., Khazipov R; Aix-Marseille Univ. INSERM, Marseille, France., Khalilov I; Aix-Marseille Univ. INSERM, Marseille, France., Martineau F; Aix-Marseille Univ. INSERM, Marseille, France., Maréchal M; Univ. Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience IINS, UMR 5297, Bordeaux, France., Lepine A; APHM, INSERM, Aix Marseille Univ, INS, Timone Hospital, Epileptology Department, Marseille, France., Milh M; APHM, INSERM, Aix Marseille Univ, INS, Timone Hospital, Epileptology Department, Marseille, France., Figarella-Branger D; APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Aix-Marseille Univ, Marseille, France., Dougy E; APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Aix-Marseille Univ, Marseille, France., Tong S; APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Aix-Marseille Univ, Marseille, France., Appay R; APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Aix-Marseille Univ, Marseille, France., Baudouin S; Corlieve Therapeutics SAS, uniQure NV, Paris, France., Mercer A; REGENXBIO, Rockville, MD, USA., Smith JB; REGENXBIO, Rockville, MD, USA., Danos O; REGENXBIO, Rockville, MD, USA., Porter R; Corlieve Therapeutics SAS, uniQure NV, Paris, France., Mulle C; Univ. Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience IINS, UMR 5297, Bordeaux, France., Crépel V; Aix-Marseille Univ. INSERM, Marseille, France.

Publikováno v: Annals of neurology [Ann Neurol] 2023 Oct; Vol. 94 (4), pp. 745-761. Date of Electronic Publication: 2023 Jul 06.

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Intracerebral hemorrhage in ICU: is it worth treating?

Autor: Sivakumar, S, Taccone, F, Desai, K, Lazaridis, C, Skarzynski, M, Sekhon, M, Henderson, W, Griesdale, D, Chapple, L, Deane, A, Williams, L, Strickland, R, Lange, K, Heyland, D, Chapman, M, Rowland, M, Garry, P, Westbrook, J, Corkill, R, Antoniades, C, Pattinson, K, Fatania, G, Strong, A, Myers, R, Jermaine, C, Robertson, C, Rusin, C, Hofmeijer, J, Sondag, L, Tjepkema Cloostermans, M, Beishuizen, A, Bosch, F, van Putten, M, Carteron, L, Patet, C, Solari, D, Oddo, M, Ali, M, Dias, C, Almeida, R, Vaz Ferreira, A, Silva, J, Monteiro, E, Cerejo, A, Rocha, A, Elsayed, A, Abougabal, A, Beshey, B, Alzahaby, K, Pozzebon, S, Ortiz, A, Cristallini, S, Lheureux, O, Brasseur, A, Vincent, J, Creteur, J, Hravnak, M, Yousef, K, Chang, Y, Crago, E, Friedlander, R, Abdelmonem, S, Tahon, S, Helmy, T, Meligy, H, Puig, F, Dunn Siegrist, I, Pugin, J, Gupta, S, Govil, D, Srinivasan, S, Patel, S, N, J, Gupta, A, Tomar, D, Shafi, M, Harne, R, Arora, D, Talwar, N, Mazumdar, S, Papakrivou, E, Makris, D, Manoulakas, E, Tsolaki, B, Karadodas, B, Zakynthinos, E, Garcia, I, Martin, A, Encinares, V, Ibañez, M, Montero, J, Labrador, G, Cangueiro, T, Poulose, V, Koh, J, Kam, J, Yeter, H, Kara, A, Aktepe, O, Topeli, A, Tsolakoglou, I, Intas, G, Stergiannis, P, Kolaros, A, Chalari, E, Athanasiadou, E, Martika, A, Fildisis, G, Faivre, V, Mengelle, C, Favier, B, Payen, D, Poppe, A, Winkler, M, Mudersbach, E, Schreiber, J, Wruck, M, Schwedhelm, E, Kluge, S, Zöllner, C, Tavladaki, T, Spanaki, A, Dimitriou, H, Kondili, E, Choulaki, C, Meleti, E, Kafetzopoulos, D, Georgopoulos, D, Briassoulis, G, la Torre, A, de la Torre Prados, M, Tsvetanova Spasova, T, Nuevo Ortega, P, Rueda Molina, C, Fernández Porcel, A, Camara Sola, E, Salido Díaz, L, García Alcántara, A, Meleti, D, Suberviola, B, Riera, J, Rellan, L, Sanchez, M, Robles, J, Lopez, E, Vicente, R, Miñambres, E, Santibañez, M, Le Guen, M, Moore, J, Mason, N, Windpassinger, M, Plattner, O, Mascha, E, Sessler, D, Research, O, Melia, U, Fontanet, J, van den Berg, J, Struys, M, Vereecke, H, Jensen, E, Rood, P, van de Schoor, F, van Tertholen, K, Pickkers, P, van den Boogaard, M, Beardow, Z, Redhead, H, Paramasivam, K, Numan, T, Kamper, A, Peelen, L, Zeman, P, Slooter, A, van Ewijk, C, Jacobs, G, Girbes, A, Myatra, S, Harish, M, Prabu, N, Siddiqui, S, Kulkarni, A, Divatia, J, Murbach, L, Leite, M, Osaku, E, Costa, C, Pelenz, M, Neitzke, N, Moraes, M, Jaskowiak, J, Silva, M, Zaponi, R, Abentroth, L, Ogasawara, S, Jorge, A, Duarte, P, Hernández Sánchez, N, Sánchez Hurtado, L, García Guillen, F, Ñamendys Silva, S, Maghsoudi, B, Emami, M, Khosravi, M, Zand, F, Tabatabaie, H, Masjedi, M, Sabetiyan, G, Mokri, A, Troubleyn, J, Diltoer, M, Jacobs, R, Nguyen, D, De Waele, E, De Regt, J, Honoré, P, Van Gorp, V, Spapen, H, Contreras, R, Toapanta, N, Moreno, G, Sabater, J, Torrado, H, Gonzalez, M, Marin, M, Farigola, E, Gonzalez, A, Fernandez, J, Vera, A, Gisbert, X, Juliá, C, Uya, J, Corral, L, Elias Jones, I, Gemmell, L, Mackay, A, Randall, D, Adwaney, A, Blunden, M, Prowle, J, Kirwan, C, Thomas, N, Owen, H, Darwin, L, Conway, D, Atkinson, D, Sharman, M, Barbanti, C, Amour, J, Gaudard, P, Rozec, B, Mauriat, P, M'Rini, M, Leger, P, Cambonie, G, Liet, J, Girard, C, Laroche, S, Damas, P, Assaf, Z, Loron, G, Lecourt, L, Pouard, P, Kim, S, Na, S, Kim, J, Oh, S, Jung, C, Yoo, S, Min, S, Chung, E, Lee, H, Lee, N, Lee, K, Suh, K, Ryu, H, Marshall, D, Goodson, R, Salciccioli, J, Shalhoub, J, Potter, E, Kirk Bayley, J, Karanjia, N, Forni, L, Creagh Brown, B, Bossy, M, Nyman, M, Tailor, A, D'Antini, D, Spadaro, S, Valentino, F, Sollitto, F, Cinnella, G, Mirabella, L, Calvo, F, Bejarano, N, Padilla, D, Baladron, V, Villajero, P, Villazala, R, Redondo, J, Yuste, A, Liu, J, Shen, F, Teboul, J, Anguel, N, Beurton, A, Bezaz, N, Richard, C, Monnet, X, Fossali, T, Colombo, R, Ottolina, D, Rossetti, M, Mazzucco, C, Marchi, A, Porta, A, Catena, E, Tollisen, K, Andersen, G, Heyerdahl, F, Jacobsen, D, de Waard, M, van IJzendoorn, M, Buter, H, 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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1299::9f24cf1b0c7da2421e69e035c89cda69
http://hdl.handle.net/10281/133116