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FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.

Autor: Wieder N; Broad Institute of MIT and Harvard, Cambridge, USA.; Department of Medicine, Brigham and Women's Hospital, Boston USA.; Harvard Medical School, Boston, USA.; Department of Neurology with Experimental Neurology, Charité, Berlin, Germany., Fried JC; Broad Institute of MIT and Harvard, Cambridge, USA.; Department of Medicine, Brigham and Women's Hospital, Boston USA.; Harvard Medical School, Boston, USA., Kim C; Broad Institute of MIT and Harvard, Cambridge, USA.; Department of Medicine, Brigham and Women's Hospital, Boston USA.; Harvard Medical School, Boston, USA., Sidhom EH; Broad Institute of MIT and Harvard, Cambridge, USA.; Department of Medicine, Brigham and Women's Hospital, Boston USA.; Harvard Medical School, Boston, USA., Brown MR; Broad Institute of MIT and Harvard, Cambridge, USA., Marshall JL; Broad Institute of MIT and Harvard, Cambridge, USA., Arevalo C; Broad Institute of MIT and Harvard, Cambridge, USA., Dvela-Levitt M; Broad Institute of MIT and Harvard, Cambridge, USA.; Department of Medicine, Brigham and Women's Hospital, Boston USA.; Harvard Medical School, Boston, USA.; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel., Kost-Alimova M; Broad Institute of MIT and Harvard, Cambridge, USA., Sieber J; Department of Endocrinology, Metabolism and Cardiovascular Systems, University of Fribourg, Fribourg, Switzerland., Gabriel KR; Broad Institute of MIT and Harvard, Cambridge, USA., Pacheco J; Broad Institute of MIT and Harvard, Cambridge, USA., Clish C; Broad Institute of MIT and Harvard, Cambridge, USA., Abbasi HS; Broad Institute of MIT and Harvard, Cambridge, USA., Singh S; Broad Institute of MIT and Harvard, Cambridge, USA., Rutter J; Broad Institute of MIT and Harvard, Cambridge, USA.; Harvard Medical School, Boston, USA., Therrien M; Broad Institute of MIT and Harvard, Cambridge, USA., Yoon H; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Ludwig Center for Cancer Research at Harvard, Boston, MA 02115, USA., Lai ZW; Harvard Chan Advanced Multiomics Platform, Harvard T.H. Chan School of Public Health, Boston MA 02115 USA., Baublis A; Harvard Chan Advanced Multiomics Platform, Harvard T.H. Chan School of Public Health, Boston MA 02115 USA., Subramanian R; Laboratory for Surgical and Metabolic Research, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Devkota R; Broad Institute of MIT and Harvard, Cambridge, USA.; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Small J; Broad Institute of MIT and Harvard, Cambridge, USA.; Harvard Medical School, Boston, USA.; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sreekanth V; Broad Institute of MIT and Harvard, Cambridge, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA, USA., Han M; Broad Institute of MIT and Harvard, Cambridge, USA., Lim D; Broad Institute of MIT and Harvard, Cambridge, USA., Carpenter AE; Broad Institute of MIT and Harvard, Cambridge, USA., Flannick J; Broad Institute of MIT and Harvard, Cambridge, USA.; Harvard Medical School, Boston, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA., Finucane H; Broad Institute of MIT and Harvard, Cambridge, USA.; Analytic and Translational Genetics Unit, Mass General Hospital, Boston, MA, USA., Haigis MC; Broad Institute of MIT and Harvard, Cambridge, USA.; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Ludwig Center for Cancer Research at Harvard, Boston, MA 02115, USA., Claussnitzer M; Broad Institute of MIT and Harvard, Cambridge, USA.; Harvard Medical School, Boston, USA.; Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sheu E; Laboratory for Surgical and Metabolic Research, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Stevens B; Broad Institute of MIT and Harvard, Cambridge, USA.; Harvard Medical School, Boston, USA.; Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA., Wagner BK; Broad Institute of MIT and Harvard, Cambridge, USA.; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Choudhary A; Broad Institute of MIT and Harvard, Cambridge, USA.; Harvard Medical School, Boston, USA.; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA, USA., Shaw JL; Broad Institute of MIT and Harvard, Cambridge, USA., Pablo JL; Broad Institute of MIT and Harvard, Cambridge, USA., Greka A; Broad Institute of MIT and Harvard, Cambridge, USA.; Department of Medicine, Brigham and Women's Hospital, Boston USA.; Harvard Medical School, Boston, USA.; Lead Contact.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 20. Date of Electronic Publication: 2023 Feb 20.