Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Batya Rinsky"'
Autor:
Michelle Grunin, Daria Triffon, Gala Beykin, Elior Rahmani, Regev Schweiger, Liran Tiosano, Samer Khateb, Shira Hagbi-Levi, Batya Rinsky, Refael Munitz, Thomas W. Winkler, Iris M. Heid, Eran Halperin, Shai Carmi, Itay Chowers
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The risk of developing age-related macular degeneration (AMD) is influenced by genetic background. In 2016, the International AMD Genomics Consortium (IAMDGC) identified 52 risk variants in 34 loci, and a polygenic risk score (PRS) from thes
Externí odkaz:
https://doaj.org/article/3409c3c4eb8c4bab900e2f3a3246f280
Publikováno v:
eLife, Vol 12 (2023)
Mononuclear cells are involved in the pathogenesis of retinal diseases, including age-related macular degeneration (AMD). Here, we examined the mechanisms that underlie macrophage-driven retinal cell death. Monocytes were extracted from patients with
Externí odkaz:
https://doaj.org/article/4eec9bad72744e968b8e36639e51e910
Autor:
Shira Hagbi-Levi, Michal Abraham, Liran Tiosano, Batya Rinsky, Michelle Grunin, Orly Eizenberg, Amnon Peled, Itay Chowers
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
Background. Age-related macular degeneration (AMD), the most common cause of blindness in the developed world, usually affects individuals older than 60 years of age. The majority of visual loss in this disease is attributable to the development of c
Externí odkaz:
https://doaj.org/article/f194585487bd4e4d8954864b07762856
Autor:
Gala Beykin, Michal Ganiel, Regev Schweiger, Itay Chowers, Elior Rahmani, Batya Rinsky, Michelle Grunin, Gal Barel, Shai Carmi, Sarah Elbaz-Hayoun, Shira Hagbi-Levi, Eran Halperin
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Anti-vascular endothelial growth factor (VEGF) therapy for neovascular AMD (nvAMD) obtains a variable outcome. We performed a genome-wide association study for anti-VEGF treatment response in nvAMD to identify variants potentially underlying
Autor:
Diego Almeida, Radgonde Amer, Itay Chowers, Sarah Elbaz-Hayoun, Samer Khateb, Batya Rinsky, Shira Hagbi-Levi, Michelle Grunin, Gala Beykin, Liran Tiosano
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Age-related macular degeneration (AMD) is associated with altered gene and protein expression in the retina. We characterize the aqueous humor (AH) proteome in AMD to gain insight into the pathogenesis of the disease and identify potential bi
Autor:
Shira Hagbi-Levi, Itay Chowers, Liran Tiosano, Amnon Peled, Batya Rinsky, Tareq Jaouni, Michelle Grunin, Sarah Elbaz-Hayoun
Publikováno v:
Neurobiology of Aging. 51:71-82
Macrophages were previously implicated in the pathogenesis of neovascular age-related macular degeneration (nvAMD). It is unclear if a specific macrophage phenotype is associated with nvAMD, and if macrophages from nvAMD patients are more pathogenic
Autor:
Amnon Peled, Michelle Grunin, Orly Eizenberg, Itay Chowers, Liran Tiosano, Batya Rinsky, Shira Hagbi-Levi, Michal Abraham
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
Journal of Immunology Research
Journal of Immunology Research
Background. Age-related macular degeneration (AMD), the most common cause of blindness in the developed world, usually affects individuals older than 60 years of age. The majority of visual loss in this disease is attributable to the development of c
Publikováno v:
Molecular Vision
Purpose Oxidative stress and macrophages have been implicated in the pathogenesis of atrophic and neovascular age-related macular degeneration (aAMD and nvAMD). It is unclear whether oxidative injury mediates macrophage involvement in AMD. We aimed t
Publikováno v:
Scientific Reports
Mononuclear phagocytes (MPs), including monocytes/macrophages, play complex roles in age-related macular degeneration (AMD) pathogenesis. We reported altered gene-expression signature in peripheral blood mononuclear cells from AMD patients and a chem