Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours

Autor: Nwosu, Z. C., Battello, N., Rothley, M., Piorońska, W., Sitek, B., Ebert, M. P., Hofmann, U., Sleeman, J., Wölfl, S., Meyer, C., Megger, D. A., Dooley, S.

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-15 (2018)
Journal of Experimental & Clinical Cancer Research : CR
Journal of experimental & clinical cancer research, 37 (1), Art. Nr.: 211

Background: Although metabolism is profoundly altered in human liver cancer, the extent to which experimental models, e.g. cell lines, mimic those alterations is unresolved. Here, we aimed to determine the resemblance of hepatocellular carcinoma (HCC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419efa207be7294435db55485882e388
http://link.springer.com/article/10.1186/s13046-018-0872-6

Lipid metabolism reprogramming in endometrial cancer: biological functions and therapeutic implications.

Autor: Wang, Xiangyu¹ (AUTHOR), Li, Yinuo¹ (AUTHOR), Hou, Xin¹ (AUTHOR), Li, Jingfang¹ (AUTHOR), Ma, Xiangyi¹ (AUTHOR) xyma@tjh.tjmu.edu.cn

Publikováno v: Cell Communication & Signaling. 9/10/2024, Vol. 22 Issue 1, p1-19. 19p.

Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance.

Autor: Nwosu ZC; Department of Medicine II, Molecular Hepatology Section, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany. Electronic address: zcnwosu@umich.edu., Piorońska W; Department of Medicine II, Molecular Hepatology Section, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany., Battello N; Luxembourg Science Center, L-4620 Differdange, Luxembourg, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362 Esch-Belval, Luxembourg., Zimmer AD; Signal Transduction Laboratory, Life Sciences Research Unit, University of Luxembourg, L-4367 Belvaux, Luxembourg., Dewidar B; Department of Medicine II, Molecular Hepatology Section, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, 31527 Tanta, Egypt., Han M; Department of Medicine II, Molecular Hepatology Section, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany., Pereira S; Department of Medicine I, Lichtenberg Research Group, Johannes Gutenberg University, Mainz, Germany., Blagojevic B; Department of Biology, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, 69120 Heidelberg, Germany., Castven D; Department of Medicine I, Lichtenberg Research Group, Johannes Gutenberg University, Mainz, Germany., Charlestin V; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, 46556 IN, United States., Holenya P; Department of Biology, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, 69120 Heidelberg, Germany., Lochead J; Department of Biology, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, 69120 Heidelberg, Germany., De La Torre C; Medical Research Center, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany., Gretz N; Medical Research Center, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany., Sajjakulnukit P; Rogel Cancer Center, University of Michigan, Ann Arbor 48109 MI, United States., Zhang L; Rogel Cancer Center, University of Michigan, Ann Arbor 48109 MI, United States., Ward MH; Rogel Cancer Center, University of Michigan, Ann Arbor 48109 MI, United States., Marquardt JU; Department of Medicine I, Lichtenberg Research Group, Johannes Gutenberg University, Mainz, Germany., di Magliano MP; Rogel Cancer Center, University of Michigan, Ann Arbor 48109 MI, United States., Lyssiotis CA; Rogel Cancer Center, University of Michigan, Ann Arbor 48109 MI, United States., Sleeman J; Medical Faculty Mannheim, ECAS TRIDOMUS-Gebäude Haus C, University of Heidelberg, 68167 Mannheim, Germany; IBCS-BIP, Campus Nord, Karlsruhe Institute for Technology (KIT), 76021 Karlsruhe, Germany., Wölfl S; Department of Biology, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, 69120 Heidelberg, Germany., Ebert MP; Department of Medicine II, Molecular Hepatology Section, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany., Meyer C; Department of Medicine II, Molecular Hepatology Section, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany., Hofmann U; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tübingen, 70376 Stuttgart, Germany., Dooley S; Department of Medicine II, Molecular Hepatology Section, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany. Electronic address: steven.dooley@medma.uni-heidelberg.de.

Publikováno v: EBioMedicine [EBioMedicine] 2020 Apr; Vol. 54, pp. 102699. Date of Electronic Publication: 2020 Apr 21.

The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain.

Autor: Ohm, Melanie¹ (AUTHOR), Hosseini, Shirin^1,2 (AUTHOR), Lonnemann, Niklas¹ (AUTHOR), He, Wei³ (AUTHOR), More, Tushar³ (AUTHOR), Goldmann, Oliver⁴ (AUTHOR), Medina, Eva⁴ (AUTHOR), Hiller, Karsten³ (AUTHOR) karsten.hiller@tu-braunschweig.de, Korte, Martin^1,2 (AUTHOR) m.korte@tu-braunschweig.de

Publikováno v: Journal of Neuroinflammation. 8/20/2024, Vol. 21 Issue 1, p1-30. 30p.

Acute neuroinflammation promotes a metabolic shift that alters extracellular vesicle cargo in the mouse brain cortex.

Autor: Vassileff, Natasha^1,2,3 (AUTHOR), Spiers, Jereme G.^1,2,3 (AUTHOR), Juliani, Juliani^1,4,5 (AUTHOR), Lowe, Rohan G. T.⁶ (AUTHOR), Datta, Keshava K.⁶ (AUTHOR), Hill, Andrew F.^1,7 (AUTHOR) Andy.Hill@vu.edu.au

Publikováno v: Journal of Extracellular Biology. Jul2024, Vol. 3 Issue 7, p1-13. 13p.