FVIII peptides presented on HLA-DP and identification of an A3 domain peptide binding with high affinity to the commonly expressed HLA-DP4

Autor: Mariarosaria Miranda, Bjarke Endel Hansen, Batoul Wehbi, Valeria Porcheddu, Floris P.J. van Alphen, Paul Kaijen, Karin Fijnvandraat, Sebastien Lacroix-Desmazes, Maartje van den Biggelaar, Bernard Maillere, Jan Voorberg, EDUC8 Consortium

Publikováno v: Haematologica, Vol 999, Iss 1 (2024)

The development of neutralizing antibodies (inhibitors) against coagulation factor VIII (FVIII) poses a major challenge in hemophilia A (HA) treatment. The formation of FVIII inhibitors is a CD4+ T-cell dependent mechanism which includes antigen pres

Externí odkaz: https://doaj.org/article/1d3765a7344b47d59f82ebbd401adcb1

Homéostasie de la réponse IgA et microbiote

Autor: Margaux Hiblot, Batoul Wehbi, Virginie Pascal, Jean-Claude Aldigier, Michel Cogné

Publikováno v: médecine/sciences
médecine/sciences, EDP Sciences, 2021, 37 (1), pp.35-40. ⟨10.1051/medsci/2020258⟩

L’immunité muqueuse s’établit en réponse à un ensemble de microorganismes qui sont surtout commensaux mais aussi, parfois, pathogènes. À cette dualité, les immunoglobulines de classe A (IgA) opposent une balance fonctionnelle allant de la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2af8cd342254d35c8e7508c53576179
https://doi.org/10.1051/medsci/2020258

Chemical Composition, Antioxidant and Anti-inflammatory Activity Evaluation of the Lebanese Propolis Extract

Autor: Mohammad Fayyad-Kazan, Alia Khalil, Rawan Zeitoun, Wissam H Faour, Fadia Najjar, Carole Dagher-Hamalian, Batoul Wehbi, Yolla El-Makhour

Publikováno v: Current Pharmaceutical Biotechnology. 20:84-96

Background:Propolis is a resinous substance produced by bees and known to possess antioxidant, antimicrobial, antiproliferative and anti-inflammatory activities.Objective:This study is aimed at evaluating the in vivo and in vitro anti-inflammatory po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2f2bba3b15ca37ec9f37d00fecc3c6
https://doi.org/10.2174/1389201020666190206201241

Mesangial deposition can strongly involve innate-like iga molecules lacking affinity maturation

Autor: Michel Cogné, Yolla Makhour, Batoul Wehbi, Jeanne Moreau, Anne Druilhe, Christelle Oblet, Arnaud Huard, Etienne Cogné, Marjolein van Egmond, Jean-Claude Aldigier, François Boyer, Bassam Badran, François Paraf

Publikováno v: Journal of the American Society of Nephrology, 30(7), 1238-1249. American Society of Nephrology
J Am Soc Nephrol
Journal of the American Society of Nephrology
Journal of the American Society of Nephrology, American Society of Nephrology, 2019, 30 (7), pp.1238-1249. ⟨10.1681/ASN.2018111089⟩
Wehbi, B, Oblet, C, Boyer, F, Huard, A, Druilhe, A, Paraf, F, Cogné, E, Moreau, J, Makhour, Y E, Badran, B, van Egmond, M, Cogné, M & Aldigier, J-C 2019, ' Mesangial deposition can strongly involve innate-like iga molecules lacking affinity maturation ', Journal of the American Society of Nephrology, vol. 30, no. 7, pp. 1238-1249 . https://doi.org/10.1681/ASN.2018111089

BACKGROUND: IgA nephropathy (IgAN) often follows infections and features IgA mesangial deposition. Polymeric IgA deposits in the mesangium seem to have varied pathogenic potential, but understanding their pathogenicity remains a challenge. Most mesan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafbaede897dfc4ac27e839f180e6c0e
https://research.vumc.nl/en/publications/8743fe3e-1f2c-4d84-a5d4-533b259cf256