Soluble 2-Substituted Aminopyrido[2,3-d]pyrimidin-7-yl Ureas. Structure−Activity Relationships against Selected Tyrosine Kinases and Exploration of in Vitro and in Vivo Anticancer Activity

Autor: Schroeder, M. C., Hamby, J. M., Connolly, C. J. C., Grohar, P. J., Winters, R. T., Barvian, M. R., Moore, C. W., Boushelle, S. L., Crean, S. M., Kraker, A. J., Driscoll, D. L., Vincent, P. W., Elliott, W. L., Lu, G. H., Batley, B. L., Dahring, T. K., Major, T. C., Panek, R. L., Doherty, A. M., Showalter, H. D. H.

Publikováno v: Journal of Medicinal Chemistry; June 2001, Vol. 44 Issue: 12 p1915-1926, 12p

Structure−Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor

Autor: Palmer, B. D., Kraker, A. J., Hartl, B. G., Panopoulos, A. D., Panek, R. L., Batley, B. L., Lu, G. H., Trumpp-Kallmeyer, S., Showalter, H. D. H., Denny, W. A.

Publikováno v: Journal of Medicinal Chemistry; July 1, 1999, Vol. 42 Issue: 13 p2373-2382, 10p

Inhibition of FGF-1 Receptor Tyrosine Kinase Activity by PD 161570, a New Protein-Tyrosine Kinase Inhibitor

Autor: Batley, B. L., Doherty, A. M., Hamby, J. M., Lu, G. H., Keller, P., Dahring, T. K., Hwang, O., Crickard, K., Panek, R. L.

Publikováno v: Life Sciences; 1997, Vol. 62 Issue: 2 p143-150, 8p

ChemInform Abstract: A Novel Orally Active Renin Inhibitor Containing 2-Amino-4-thiazolyl- alanine at P2 with a Long Duration of Action in a Primate Model of Hypertension.

Autor: PATT, W. C., HAMILTON, H. W., RYAN, M. J., PAINCHAUD, C. A., TAYLOR, M. D., RAPUNDALO, S. T., BATLEY, B. L., CONNOLLY, C. J. C., TAYLOR, D. G. JUN.

Publikováno v: ChemInform; Aug1992, Vol. 23 Issue 34, pno-no, 1p

Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity.

Autor: Schroeder MC; Departments of Chemistry, Cancer Research, and Vascular and Cardiac Diseases, Pfizer Global Research & Development, Ann Arbor Laboratories, 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA. mel.schroeder@pfizer.com, Hamby JM, Connolly CJ, Grohar PJ, Winters RT, Barvian MR, Moore CW, Boushelle SL, Crean SM, Kraker AJ, Driscoll DL, Vincent PW, Elliott WL, Lu GH, Batley BL, Dahring TK, Major TC, Panek RL, Doherty AM, Showalter HD

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2001 Jun 07; Vol. 44 (12), pp. 1915-26.