Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Batjargal Gundsambuu"'
Autor:
Veronika Bandara, Jade Foeng, Batjargal Gundsambuu, Todd S. Norton, Silvana Napoli, Dylan J. McPeake, Timona S. Tyllis, Elaheh Rohani-Rad, Caitlin Abbott, Stuart J. Mills, Lih Y. Tan, Emma J. Thompson, Vasiliki M. Willet, Victoria J. Nikitaras, Jieren Zheng, Iain Comerford, Adam Johnson, Justin Coombs, Martin K. Oehler, Carmela Ricciardelli, Allison J. Cowin, Claudine S. Bonder, Michael Jensen, Timothy J. Sadlon, Shaun R. McColl, Simon C. Barry
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Chimeric antigen receptor (CAR)-T cell immunotherapy is a novel treatment that genetically modifies the patients’ own T cells to target and kill malignant cells. However, identification of tumour-specific antigens expressed on multiple sol
Externí odkaz:
https://doaj.org/article/a5287b5698b04be1aa66caa9922e1384
Autor:
Veronika Bandara, Victoria M Niktaras, Vasiliki J Willett, Hayley Chapman, Noor A Lokman, Anne M Macpherson, Silvana Napoli, Batjargal Gundsambuu, Jade Foeng, Timothy J Sadlon, Justin Coombs, Shaun R McColl, Simon C Barry, Martin K Oehler, Carmela Ricciardelli
Publikováno v:
Clinical & Translational Immunology, Vol 13, Iss 5, Pp n/a-n/a (2024)
Abstract Objectives Recent studies have identified expression of the non‐functional P2X7 (nfP2X7) receptor on various malignant cells including ovarian cancer, but not on normal cells, which makes it a promising tumour‐associated antigen candidat
Externí odkaz:
https://doaj.org/article/a34eb2d9adae4c50973532aecbe3bf90
Autor:
Ying Y. Wong, Jessica E. Harbison, Christopher M. Hope, Batjargal Gundsambuu, Katherine A. Brown, Soon W. Wong, Cheryl Y Brown, Jennifer J. Couper, Jimmy Breen, Ning Liu, Stephen M. Pederson, Maren Köhne, Kathrin Klee, Joachim Schultze, Marc Beyer, Timothy Sadlon, Simon C. Barry
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Epigenetic features such as DNA accessibility dictate transcriptional regulation in a cell type- and cell state- specific manner, and mapping this in health vs. disease in clinically relevant material is opening the door to new mechanistic i
Externí odkaz:
https://doaj.org/article/a56eda72cadc4472b5afe216794b04ff
Autor:
Cheryl Y. Brown, Timothy Sadlon, Christopher M. Hope, Ying Y. Wong, Soon Wong, Ning Liu, Holly Withers, Katherine Brown, Veronika Bandara, Batjargal Gundsambuu, Stephen Pederson, James Breen, Sarah Anne Robertson, Alistair Forrest, Marc Beyer, Simon Charles Barry
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
There has been much interest in the ability of regulatory T cells (Treg) to switch function in vivo, either as a result of genetic risk of disease or in response to environmental and metabolic cues. The relationship between levels of FOXP3 and functi
Externí odkaz:
https://doaj.org/article/6dbb30a28ff74c4f98b300019ce7d841
Publikováno v:
Polymers, Vol 12, Iss 2, p 367 (2020)
Injectable, thermoresponsive hydrogels are promising candidates for the delivery, maintenance and controlled release of adoptive cell therapies. Therefore, there is significant interest in the development of cytocompatible and biodegradable thermores
Externí odkaz:
https://doaj.org/article/8b09c99b072d4ccb98f748a1c39443b8
Autor:
Jie Yan, Batjargal Gundsambuu, Marta Krasowska, Kirsten Platts, Paula Facal Marina, Cobus Gerber, Simon C. Barry, Anton Blencowe
Publikováno v:
Journal of Materials Chemistry B. 10:3329-3343
Refereed/Peer-reviewed Engineered T-cell therapies have proven highly efficacious for the treatment of haematological cancers, but translation of this success to solid tumours has been limited, in part, due to difficulties in maintaining high doses a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363687d7e45bbd3f6d380c06e01271e9
https://doi.org/10.1039/d2tb00274d
https://doi.org/10.1039/d2tb00274d
Autor:
Ying Y. Wong, Jessica E. Harbison, Christopher M. Hope, Batjargal Gundsambuu, Katherine A. Brown, Soon W. Wong, Cheryl Brown, Jennifer J. Couper, Jimmy Breen, Ning Liu, Stephen M. Pederson, Maren Köhne, Kathrin Klee, Joachim Schultze, Marc Beyer, Timothy Sadlon, Simon C. Barry
Publikováno v:
Scientific reports 13(1), 5506 (2023). doi:10.1038/s41598-023-32256-6
The epigenome and transcriptome constitute a critical element of a tightly regulated, cell-type specific gene expression program, and subtle perturbations in the regulation of this program can result in pathology. Epigenetic features such as DNA acce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3162034595646818eb1e8520da05ba24
https://doi.org/10.21203/rs.3.rs-1862932/v1
https://doi.org/10.21203/rs.3.rs-1862932/v1
Autor:
Timona Tyllis, Caitlin Abbott, Dylan McPeake, Jade Foeng, Veronika Bandara, Batjargal Gundsambuu, Silvana Napoli, Stuart Mills, Emma Thompson, Lih Tan, Allison Cowin, Claudine Bonder, Timothy Sadlon, Simon Barry, Shaun McColl
Publikováno v:
Cancer Research. 83:3199-3199
The measurement of chimeric antigen receptor (CAR) expression is critical for the development, qualification and quantitation of CAR-T cells for clinical applications. There is a comprehensive range of tools commercially available for specifically me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8949f47b302e1517e8d12bd1baf6373
https://doi.org/10.1158/1538-7445.am2023-3199
https://doi.org/10.1158/1538-7445.am2023-3199
Autor:
Emma J. Thompson, Veronika Bandara, Batjargal Gundsambuu, Silvana Napoli, Stuart Mills, Jade Foeng, Dylan McPeake, Timona Tyllis, Caitlin Abbott, Allison Cowin, Timothy Sadlon, Shaun McColl, Carmela Ricciardelli, Simon C. Barry, Claudine S. Bonder
Publikováno v:
Cancer Research. 83:5545-5545
Leucine-rich repeat containing G-protein coupled receptor (LGR5) is stem cell marker that potentiates canonical signaling in the Wnt/β-catenin signaling pathway (Barker et al. 2007). LGR5 is known to be expressed on several tissues; particularly the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bcb1fad065c34a32a2c37c50406a087
https://doi.org/10.1158/1538-7445.am2023-5545
https://doi.org/10.1158/1538-7445.am2023-5545
Autor:
Dylan McPeake, Timona Tyllis, Caitlin Abbott, Jade Foeng, Veronika Bandara, Batjargal Gundsambuu, Elaheh Rohani-Rad, Silvana Napoli, Timothy Sadlon, Simon Barry, Shaun McColl
Publikováno v:
Cancer Research. 83:4083-4083
While CAR-T cells have demonstrated significant efficacy in the treatment of haematological malignancies, there are many challenges to overcome in developing CAR-T cell therapies against solid tumours. In particular, the scarcity of recognised effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8715283208ef576f63f28f57a0012560
https://doi.org/10.1158/1538-7445.am2023-4083
https://doi.org/10.1158/1538-7445.am2023-4083