The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia

Autor: Sadek Amhaz, Batiste Boëda, Mouna Chouchène, Sabrina Colasse, Florent Dingli, Damarys Loew, Julien Henri, Céline Prunier, Laurence Levy

Publikováno v: BMC Biology, Vol 21, Iss 1, Pp 1-22 (2023)

Abstract Background E3 ubiquitin ligases play critical roles in regulating cellular signaling pathways by inducing ubiquitylation of key components. RNF111/Arkadia is a RING E3 ubiquitin ligase that activates TGF-β signaling by inducing ubiquitylati

Externí odkaz: https://doaj.org/article/4d59593c44454d2c8d1c621efb3821b6

The functional specificity of CDC42 isoforms is caused by their distinct subcellular localization

Autor: Yamini Ravichandran, Jan Hänisch, Kerren Murray, Vanessa Roca, Florent Dingli, Damarys Loew, Valentin Sabatet, Batiste Boëda, Theresia Stradal, Sandrine Etienne-Manneville

The small G-protein CDC42 is an evolutionary conserved polarity protein and a key regulator of numerous polarized cell functions, including directed cell migration. In vertebrates, alternative splicing gives rise to two CDC42 proteins: the ubiquitous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd54275cda672c7b389970be045a1bba
https://doi.org/10.1101/2023.02.27.528078

Spectrin binding motifs regulate Scribble cortical dynamics and polarity function

Autor: Batiste Boëda, Sandrine Etienne-Manneville

Publikováno v: eLife, Vol 4 (2015)

The tumor suppressor protein Scribble (SCRIB) plays an evolutionary conserved role in cell polarity. Despite being central for its function, the molecular basis of SCRIB recruitment and stabilization at the cell cortex is poorly understood. Here we s

Externí odkaz: https://doaj.org/article/859f7e4670d24d4bb0d0317099d8913c

Microtubules tune mechanosensitive cell responses

Autor: Stéphane Vassilopoulos, Batiste Boëda, Vanessa Roca, Aaron J. Farrugia, Sandrine Etienne-Manneville, Benoit Vianay, Manuel Théry, Alexander D. Bershadsky, Damarys Loew, Chiara De Pascalis, Shailaja Seetharaman, Florent Dingli

Publikováno v: Nature Materials
Nature Materials, 2021, ⟨10.1038/s41563-021-01108-x⟩
Nature Materials, Nature Publishing Group, 2021, ⟨10.1038/s41563-021-01108-x⟩

International audience; Mechanotransduction is a process by which cells sense the mechanical properties of their surrounding environment and adapt accordingly to perform cellular functions such as adhesion, migration and differentiation. Integrin-med

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fb9bbcbda4324063826ba746b60848
https://hal-pasteur.archives-ouvertes.fr/pasteur-03096554

Intermediate filaments control collective migration by restricting traction forces and sustaining cell–cell contacts

Autor: Sandrine Etienne-Manneville, Nicolas Borghi, Mithila Burute, Shailaja Seetharaman, Chiara De Pascalis, Xavier Trepat, Batiste Boëda, Carlos Pérez-González, Cécile Leduc, Benoit Vianay

Publikováno v: The Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2018, 217 (9), pp.3031-3044. ⟨10.1083/jcb.201801162⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Cell Biology 9 (217), 3031-3044. (2018)
Journal of Cell Biology, 2018, 217 (9), pp.3031-3044. ⟨10.1083/jcb.201801162⟩

Using an in vitro wound healing assay, De Pascalis et al. show that intermediate filaments (IFs) participate in the dynamics of the acto-myosin network and its association with adhesions in astrocytes during collective migration. Glial IFs control th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c12ff14c8ddb7d8beb8af38a443b0b
http://europepmc.org/articles/PMC6122997