Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Batika M J, Rana"'
Autor:
Martin D. Knolle, Shau Bing Chin, Batika M. J. Rana, Alexandros Englezakis, Rinako Nakagawa, Padraic G. Fallon, Anna Git, Andrew N. J. McKenzie
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Group-2 innate lymphoid cells (ILC2) play critical roles in the initiation and maintenance of type-2 immune responses, predominantly through their production of the type-2 cytokines IL-5, IL-9, and IL-13. ILC2 are essential for the efficient eliminat
Externí odkaz:
https://doaj.org/article/e75d7c8cf6e14c20bf252f07e4d13696
Autor:
Mark Wing, Morgan W. D. Heycock, Caroline A. Oedekoven, Jennifer A. Walker, Meera Sivasubramaniam, David G. Kent, Richard Pannell, Mayuri Gogoi, Gareth King, Lesley F Drynan, Noé Rodríguez-Rodríguez, Andrew J. Easton, Andrew N. J. McKenzie, Jillian L. Barlow, Padraic G. Fallon, Helen E. Jolin, Michael R. G. Hodskinson, Batika M. J. Rana, Veera Panova
Publikováno v:
Mucosal Immunology
Type-2 immunity is characterised by interleukin (IL)-4, IL-5 and IL-13, eosinophilia, mucus production, IgE, and alternatively activated macrophages (AAM). However, despite the lack of neutrophil chemoattractants such as CXCL1, neutrophils, a feature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6056ae64d6790cc546acf03aa95e39
https://doi.org/10.1038/s41385-020-0298-2
https://doi.org/10.1038/s41385-020-0298-2
Autor:
Jaideep Dhariwal, Aoife Cameron, Ernie Wong, Malte Paulsen, Maria-Belen Trujillo-Torralbo, Ajerico del Rosario, Eteri Bakhsoliani, Tatiana Kebadze, Mark Almond, Hugo Farne, Leila Gogsadze, Julia Aniscenko, Batika M. J. Rana, Trevor T. Hansel, David J. Jackson, Onn Min Kon, Michael R. Edwards, Roberto Solari, David J. Cousins, Ross P. Walton, Sebastian L. Johnston, Paul Lavender, Hannah Gould, David Cousins, Antoon J. van Oosterhout, Nathan W. Bartlett, Patrick Mallia, Jerico del Rosario, Janet L. Smith, Matthew J. Edwards, Karen Affleck, Nil Turan Jurdzinski, Veronique Birault, Peter McErlean, Yu-Chang Wu, Nadine Upton, Ismael Ranz Jimenez
Publikováno v:
Am J Respir Crit Care Med
RATIONALE: Type 2 innate lymphoid cells (ILC2s) are significant sources of type 2 cytokines, which are implicated in the pathogenesis of asthma and asthma exacerbations. The role of ILC2s in virus-induced asthma exacerbations is not well characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816761f5244c7709ec80777271040f45
https://europepmc.org/articles/PMC8786078/
https://europepmc.org/articles/PMC8786078/
Autor:
Meera Sivasubramaniam, Jennifer A. Walker, Antonio Vidal-Puig, Eric Jou, Helle F. Jørgensen, Clare S. Hardman, Jillian L. Barlow, Jorge Caamano, Stefania Carobbio, Sara Cruz Migoni, Matthew Sleeman, Ian C. Scott, Chiamaka I Chidomere, Noé Rodríguez-Rodríguez, Aydan Szeto, Andrew N. J. McKenzie, E. Suzanne Cohen, Batika M. J. Rana, Claire Knox, Helen E. Jolin
Publikováno v:
The Journal of Experimental Medicine
Rana et al. demonstrate that white adipose tissue-resident multipotent stromal cells (WAT-MSC) support IL-33– and LFA-1/ICAM-1–mediated proliferation and type-2 cytokine expression by ILC2. Inversely, ILC2-derived IL-4 and IL-13 promote WAT-MSC e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a4f1b6bdf18591fbe8b7247f7375ad
Autor:
Andrew N. J. McKenzie, Ashutosh K. Pandey, Deepali Jhamb, Bernhard Kerscher, Batika M. J. Rana, Mayuri Gogoi, Michelle Anne Bartholomew, Helen E. Jolin, Antoon J. M. van Oosterhout, Jillian L. Barlow, David F. Tough
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology
Group 2 innate lymphoid cells (ILC2) increase in frequency in eczema and allergic asthma patients, and thus represent a new therapeutic target cell for type-2 immune-mediated disease. The bromodomain and extra-terminal (BET) protein family of epigene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1620ab865b70060e49a848b0397ecb
https://doi.org/10.3389/fimmu.2019.00678
https://doi.org/10.3389/fimmu.2019.00678
Autor:
Marina Botto, Hans-Reimer Rodewald, Bernhard Kerscher, Andrew N. J. McKenzie, Timothy J. Vyse, Liora Haim-Vilmovsky, Martin D. Knolle, Padraic G. Fallon, David R. Withers, Helen E. Jolin, Batika M. J. Rana, Sarah A. Teichmann, Zhi Li, Eva M. Serrao, Jennifer A. Walker, Timotheus Y.F. Halim
Publikováno v:
1207.e6
Halim, T Y F, Rana, B M J, Walker, J A, Kerscher, B, Knolle, M D, Jolin, H E, Serrao, E M, Haim-Vilmovsky, L, Teichmann, S A, Rodewald, H-R, Botto, M, Vyse, T J, Fallon, P G, Li, Z, Withers, D R & McKenzie, A N J 2018, ' Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells ', Immunity . https://doi.org/10.1016/j.immuni.2018.05.003
Halim, T Y F, Rana, B M J, Walker, J A, Kerscher, B, Knolle, M D, Jolin, H E, Serrao, E M, Haim-Vilmovsky, L, Teichmann, S A, Rodewald, H-R, Botto, M, Vyse, T J, Fallon, P G, Li, Z, Withers, D R & McKenzie, A N J 2018, ' Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells ', Immunity . https://doi.org/10.1016/j.immuni.2018.05.003
The local regulation of type 2 immunity relies on dialog between the epithelium and the innate and adaptive immune cells. Here we found that alarmin-induced expression of the co-stimulatory molecule OX40L on group 2 innate lymphoid cells (ILC2s) prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9583286f0fb5308558d51586f5b2a11c
http://hdl.handle.net/10044/1/60440
http://hdl.handle.net/10044/1/60440
Autor:
Andrew N. J. McKenzie, Paul S. Foster, Chantal Donovan, Bernadette Jones, Peter A. B. Wark, Richard Kim, Prema M. Nair, Philip M. Hansbro, Tatt Jhong Haw, Jillian L. Barlow, Kurtis F. Budden, Guy J. M. Cameron, Malcolm R. Starkey, Batika M. J. Rana, Jay C. Horvat
Publikováno v:
Journal of Leukocyte Biology
Pulmonary inflammation in chronic obstructive pulmonary disease (COPD) is characterized by both innate and adaptive immune responses; however, their specific roles in the pathogenesis of COPD are unclear. Therefore, we investigated the roles of T and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff51df3ba555a399778a6508bb3e4ef
https://pubmed.ncbi.nlm.nih.gov/30260499
https://pubmed.ncbi.nlm.nih.gov/30260499
Publikováno v:
The Journal of Allergy and Clinical Immunology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e561f80f83b774f453f65a67a90e13f6
https://pubmed.ncbi.nlm.nih.gov/30205185
https://pubmed.ncbi.nlm.nih.gov/30205185
Publikováno v:
Immunotherapy. 7:607-610
Allergic asthma is a prevalent disease characterized by intermittent airway hyperresponsiveness resulting in airway narrowing, debilitating wheezing and shortness of breath that in severe cases can prove fatal. Notably, the number of sufferers, espec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc6889357d68a950f2c06fd72ce0641
https://doi.org/10.2217/imt.15.36
https://doi.org/10.2217/imt.15.36
Autor:
Batika M. J. Rana, Aoife Cameron, David J. Cousins, Ajerico del Rosario, Trevor T. Hansel, David A. Jackson, Eteri Bakhsoliani, Jaideep Dhariwal, Michael R. Edwards, Malte Paulsen, Maria-Belen Trujillo-Torralbo, Ross P. Walton, Sebastian L. Johnston
RATIONALE: Newly characterised type 2 innate lymphoid cells display potent type 2 effector functionality, however their contribution to allergic airways inflammation and asthma is poorly understood. Mucosal biopsy used to characterise the airway muco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31804b0252d5a11b9591737029f26cb5
http://hdl.handle.net/10044/1/44042
http://hdl.handle.net/10044/1/44042