Associations between voxel-level accumulated dose and rectal toxicity in prostate radiotherapy

Autor: Shelley, Leila E.A., Sutcliffe, Michael P.F., Thomas, Simon J., Noble, David J., Romanchikova, Marina, Harrison, Karl, Bates, Amy M., Burnet, Neil G., Jena, Raj

Publikováno v: In Physics and Imaging in Radiation Oncology April 2020 14:87-94

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Identifying risk factors for L'Hermitte's sign after IMRT for head and neck cancer

Autor: Laidley, Hannah M, Noble, David, Barnett, Gill C, Forman, Julia R, Bates, Amy M, Benson, Richard J, Jefferies, Sarah J, Jena, Rajesh, Burnet, Neil

Publikováno v: Laidley, H M, Noble, D J, Barnett, G C, Forman, J R, Bates, A M, Benson, R J, Jefferies, S J, Jena, R & Burnet, N G 2018, ' Identifying risk factors for L'Hermitte's sign after IMRT for head and neck cancer ', Radiation Oncology, vol. 13, no. 1, 84 . https://doi.org/10.1186/s13014-018-1015-0

BACKGROUND: L'Hermitte's sign (LS) after chemoradiotherapy for head and neck cancer appears related to higher spinal cord doses. IMRT plans limit spinal cord dose, but the incidence of LS remains high. METHODS: One hundred seventeen patients treated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6a927c02a5532d38acd06cc59a5b1e

Accumulated dose to the rectum, measured using dose–volume histograms and dose-surface maps, is different from planned dose in all patients treated with radiotherapy for prostate cancer

Autor: Scaife, Jessica E, Thomas, Simon J, Harrison, Karl, Romanchikova, Marina, Sutcliffe, Michael PF, Forman, Julia R, Bates, Amy M, Jena, Raj, Parker, M Andrew, Burnet, Neil G

Publikováno v: The British Journal of Radiology

OBJECTIVE: We sought to calculate accumulated dose (DA) to the rectum in patients treated with radiotherapy for prostate cancer. We were particularly interested in whether dose-surface maps (DSMs) provide additional information to dose-volume histogr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::67d816e2eb11606a0adfaaf45fb8d157
http://europepmc.org/articles/PMC4730972

Large-scale meta-genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types.

Autor: Naderi E; Department of Epidemiology, University Medical Center Groningen, Groningen, The Netherlands.; Department of Radiation Oncology, University Medical Center Groningen, Groningen, The Netherlands.; Center for Statistical Genetics, Gertrude H. Sergievsky Center, and the Department of Neurology, Columbia University Medical Center, New York, NY, USA., Aguado-Barrera ME; Fundación Pública Galega Medicina Xenómica, Santiago de Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Schack LMH; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.; Department of Oncology, Gødstrup Hospital, Herning, Denmark.; NIDO | Centre for Research and Education, Gødstrup Hospital, Herning, Denmark., Dorling L; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Rattay T; Leicester Cancer Research Centre, University of Leicester, Leicester, UK., Fachal L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Summersgill H; Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester, UK., Martínez-Calvo L; Fundación Pública Galega Medicina Xenómica, Santiago de Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain., Welsh C; Department of Oncology, University of Cambridge, Cambridge, UK., Dudding T; Bristol Dental School, University of Bristol, Bristol, UK.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Odding Y; Bristol Cancer Institute, University Hospitals Bristol NHS Foundation Trust, Bristol, UK., Varela-Pazos A; Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain., Jena R; Department of Oncology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK., Thomson DJ; Division of Cancer Sciences, University of Manchester, Manchester, UK.; The Christie NHS Foundation Trust, Manchester, UK., Steenbakkers RJHM; Department of Radiation Oncology, University Medical Center Groningen, Groningen, The Netherlands., Dennis J; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Lobato-Busto R; Department of Medical Physics, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain., Alsner J; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark., Ness A; Bristol Dental School, University of Bristol, Bristol, UK., Nutting C; Head and Neck Unit, The Royal Marsden Hospital, London, UK., Gómez-Caamaño A; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain., Eriksen JG; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark., Thomas SJ; Bristol Dental School, University of Bristol, Bristol, UK., Bates AM; Department of Oncology, University of Cambridge, Cambridge, UK., Webb AJ; Department of Genetics and Genome Biology, University of Leicester, Leicester, UK., Choudhury A; Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, UK., Rosenstein BS; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Taboada-Valladares B; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain., Herskind C; Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Azria D; Fédération Universitaire d'Oncologie Radiothérapie d'Occitanie Méditérranée, Département d'Oncologie Radiothérapie, ICM Montpellier, INSERM U1194 IRCM, University of Montpellier, Montpellier, France., Dearnaley DP; Division of Radiotherapy and Imaging, The Institute of Cancer Research Department, The Royal Marsden NHS Foundation Trust, London, UK., de Ruysscher D; MAASTRO Clinic, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands., Sperk E; Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Hall E; Clinical Trials and Statistics Unit, The Institute of Cancer Research, London, UK., Stobart H; Patient Advocate, Independent Cancer Patients' Voice, London, UK., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.; University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., De Ruyck K; Departments of Basic Medical Sciences and Radiotherapy, Ghent University Hospital, Ghent, Belgium., Veldeman L; Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium., Altabas M; Radiation Oncology Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain., De Santis MC; Radiation Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Farcy-Jacquet MP; Fédération Universitaire d'Oncologie Radiothérapie d'Occitanie Méditérranée, Département d'Oncologie Radiothérapie, CHU Carémeau, Nîmes, France., Veldwijk MR; Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Sydes MR; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Parliament M; Division of Radiation Oncology, Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada., Usmani N; Division of Radiation Oncology, Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada., Burnet NG; The Christie NHS Foundation Trust, Manchester, UK., Seibold P; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Symonds RP; Cancer Research Centre, University of Leicester, Leicester, UK., Elliott RM; Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, UK., Bultijnck R; Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium., Gutiérrez-Enríquez S; Hereditary Cancer Genetics Group, Vall d'Hebron Institute of Oncology, Vall d'Hebron Hospital Campus, Barcelona, Spain., Mollà M; Radiation Oncology Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain., Gulliford SL; Department of Medical Physics and Biomedical Engineering, University College London, UK., Green S; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rancati T; Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Reyes V; Radiation Oncology Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain., Carballo A; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain., Peleteiro P; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain., Sosa-Fajardo P; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain., Parker C; Department of Medical Physics and Biomedical Engineering, University College London, UK., Fonteyne V; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium., Johnson K; Leicester Cancer Research Centre, University of Leicester, Leicester, UK., Lambrecht M; Radiation Oncology, KU Leuven, Leuven, Belgium., Vanneste B; Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.; Department of Radiation Oncology (Maastro Clinic), GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands., Valdagni R; Radiation Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.; Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Giraldo A; Radiation Oncology Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain., Ramos M; Radiation Oncology Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain., Diergaarde B; Department of Human Genetics, School of Public Health, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Liu G; Princess Margaret Cancer Centre, Temerty Faculty of Medicine, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Leal SM; Center for Statistical Genetics, Gertrude H. Sergievsky Center, and the Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Taub Institute for Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA., Chua MLK; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore.; Duke-NUS Medical School, Oncology Academic Clinical Programme, Singapore., Pring M; Bristol Dental School, University of Bristol, Bristol, UK., Overgaard J; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark., Cascallar-Caneda LM; Department of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain., Duprez F; Department of Human Structure and Repair, Ghent University, Ghent, Belgium.; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium., Talbot CJ; Department of Genetics and Genome Biology, University of Leicester, Leicester, UK., Barnett GC; Department of Oncology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Vega A; Fundación Pública Galega Medicina Xenómica, Santiago de Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.; Grupo de Medicina Xenómica, Centro de Investigación Biomédica en Red de Enfermedades Raras, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Andreassen CN; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Langendijk JA; Department of Radiation Oncology, University Medical Center Groningen, Groningen, The Netherlands., West CML; Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie NHS Foundation Trust Hospital, Manchester, UK., Alizadeh BZ; Department of Epidemiology, University Medical Center Groningen, Groningen, The Netherlands., Kerns SL; Department of Radiation Oncology, The Medical College of Wisconsin, Milwaukee, WI, USA.

Publikováno v: JNCI cancer spectrum [JNCI Cancer Spectr] 2023 Oct 31; Vol. 7 (6).