Nanobubbles for therapeutic delivery: Production, stability and current prospects

Autor: Batchelor, DVB, Armistead, FJ, Ingram, N, Peyman, SA, Mclaughlan, JR, Coletta, PL, Evans, SD

Nanobubbles (NBs) have recently garnered widespread attention for their potential use as dual diagnostic and therapeutic agents. Similar to their micron-sized relatives (microbubbles), NBs are shell-stabilized, gas-cored bubbles that in conjunction w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::da9e35d2e6b747ee8b51a8ed58386b73

Freeze-Dried Therapeutic Microbubbles: Stability and Gas Exchange

Autor: Abou-Saleh, RH, Delaney, A, Ingram, N, Batchelor, DVB, Johnson, BRG, Charalambous, A, Bushby, RJ, Peyman, SA, Coletta, PL, Markham, AF, Evans, SD

Microbubbles (MBs) are widely used as contrast enhancement agents for ultrasound imaging and have the potential to enhance therapeutic delivery to diseases such as cancer. Yet, they are only stable in solution for a few hours to days after production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::43534b34605f8790910ff52d63dc4804
https://eprints.whiterose.ac.uk/167109/21/acsabm.0c00982.pdf

High-throughput microfluidics for evaluating microbubble enhanced delivery of cancer therapeutics in spheroid cultures

Autor: Bourn, MD, Batchelor, DVB, Ingram, N, McLaughlan, JR, Coletta, PL, Evans, SD, Peyman, SA

Drug penetration into solid tumours remains a major challenge in the effective treatment of cancer. Microbubble (MB) mediated sonoporation offers a potential solution to this by enhancing the uptake of drugs into cells. Additionally, in using an ultr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f847cd5633ebe98d5110721fc5dc6785

QCM-D Investigations on Cholesterol-DNA Tethering of Liposomes to Microbubbles for Therapy.

Autor: Armistead FJ; Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom., Batchelor DVB; Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom., Johnson BRG; Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom., Evans SD; Molecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom.

Publikováno v: The journal of physical chemistry. B [J Phys Chem B] 2023 Mar 23; Vol. 127 (11), pp. 2466-2474. Date of Electronic Publication: 2023 Mar 14.

A Single Short 'Tone Burst' Results in Optimal Drug Delivery to Tumours Using Ultrasound-Triggered Therapeutic Microbubbles.

Autor: Ingram N; Leeds Institute of Medical Research, Faculty of Medicine and Health, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK., McVeigh LE; Leeds Institute of Medical Research, Faculty of Medicine and Health, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK., Abou-Saleh RH; School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, UK.; Nanoscience and Technology Group, Faculty of Science, Galala University, Galala 43711, Egypt.; Department of Physics, Mansoura University, Mansoura 35516, Egypt., Batchelor DVB; School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, UK., Loadman PM; Institute of Cancer Therapeutics, University of Bradford, Bradford BD7 1DP, UK., McLaughlan JR; Leeds Institute of Medical Research, Faculty of Medicine and Health, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.; School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT, UK., Markham AF; Leeds Institute of Medical Research, Faculty of Medicine and Health, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK., Evans SD; School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, UK., Coletta PL; Leeds Institute of Medical Research, Faculty of Medicine and Health, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

Publikováno v: Pharmaceutics [Pharmaceutics] 2022 Mar 11; Vol. 14 (3). Date of Electronic Publication: 2022 Mar 11.