The landscape of tolerated genetic variation in humans and primates.

Autor: Gao H; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., Hamp T; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., Ede J; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., Schraiber JG; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., McRae J; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., Singer-Berk M; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard; Boston, Massachusetts, 02142, USA., Yang Y; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., Dietrich A; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., Fiziev P; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., Kuderna L; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA.; Institute of Evolutionary Biology (UPF-CSIC); PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain., Sundaram L; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., Wu Y; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., Adhikari A; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., Field Y; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., Chen C; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., Batzoglou S; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., Aguet F; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA., Lemire G; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard; Boston, Massachusetts, 02142, USA.; Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School; Boston, Massachusetts, 02115, USA., Reimers R; Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School; Boston, Massachusetts, 02115, USA., Balick D; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School; Boston, Massachusetts, 02115, USA., Janiak MC; School of Science, Engineering & Environment, University of Salford; Salford, M5 4WT, United Kingdom., Kuhlwilm M; Institute of Evolutionary Biology (UPF-CSIC); PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain.; Department of Evolutionary Anthropology, University of Vienna; Djerassiplatz 1, 1030, Vienna, Austria.; Human Evolution and Archaeological Sciences (HEAS), University of Vienna; 1030, Vienna, Austria., Orkin JD; Institute of Evolutionary Biology (UPF-CSIC); PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain.; Département d'anthropologie, Université de Montréal; 3150 Jean-Brillant, Montréal, QC, H3T 1N8, Canada., Manu S; Academy of Scientific and Innovative Research (AcSIR); Ghaziabad, 201002, India.; Laboratory for the Conservation of Endangered Species, CSIR-Centre for Cellular and Molecular Biology; Hyderabad, 500007, India., Valenzuela A; Institute of Evolutionary Biology (UPF-CSIC); PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain., Bergman J; Bioinformatics Research Centre, Aarhus University; Aarhus, 8000, Denmark.; Section for Ecoinformatics & Biodiversity, Department of Biology, Aarhus University; Aarhus, 8000, Denmark., Rouselle M; Bioinformatics Research Centre, Aarhus University; Aarhus, 8000, Denmark., Silva FE; Research Group on Primate Biology and Conservation, Mamirauá Institute for Sustainable Development; Estrada da Bexiga 2584, Tefé, Amazonas, CEP 69553-225, Brazil.; Faculty of Sciences, Department of Organismal Biology, Unit of Evolutionary Biology and Ecology, Université Libre de Bruxelles (ULB); Avenue Franklin D. Roosevelt 50, 1050, Brussels, Belgium., Agueda L; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST); Baldiri i Reixac 4, 08028, Barcelona, Spain., Blanc J; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST); Baldiri i Reixac 4, 08028, Barcelona, Spain., Gut M; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST); Baldiri i Reixac 4, 08028, Barcelona, Spain., de Vries D; School of Science, Engineering & Environment, University of Salford; Salford, M5 4WT, United Kingdom., Goodhead I; School of Science, Engineering & Environment, University of Salford; Salford, M5 4WT, United Kingdom., Harris RA; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine; Houston, Texas, 77030, USA., Raveendran M; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine; Houston, Texas, 77030, USA., Jensen A; Department of Ecology and Genetics, Animal Ecology, Uppsala University; SE-75236, Uppsala, Sweden., Chuma IS; Tanzania National Parks; Arusha, Tanzania., Horvath J; North Carolina Museum of Natural Sciences; Raleigh, North Carolina, 27601, USA.; Department of Biological and Biomedical Sciences, North Carolina Central University; Durham, North Carolina , 27707, USA.; Department of Biological Sciences, North Carolina State University; Raleigh, North Carolina , 27695, USA.; Department of Evolutionary Anthropology, Duke University; Durham, North Carolina , 27708, USA.; Renaissance Computing Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Hvilsom C; Copenhagen Zoo; 2000 Frederiksberg, Denmark., Juan D; Institute of Evolutionary Biology (UPF-CSIC); PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain., Frandsen P; Copenhagen Zoo; 2000 Frederiksberg, Denmark., de Melo FR; Universidade Federal de Viçosa; Viçosa, 36570-900, Brazil., Bertuol F; Universidade Federal do Amazonas, Departamento de Genética, Laboratório de Evolução e Genética Animal (LEGAL); Manaus, Amazonas, 69080-900, Brazil., Byrne H; Department of Anthropology, University of Utah; Salt Lake City, Utah, 84102, USA., Sampaio I; Universidade Federal do Para; Guamá, Belém - PA, 66075-110, Brazil., Farias I; Universidade Federal do Amazonas, Departamento de Genética, Laboratório de Evolução e Genética Animal (LEGAL); Manaus, Amazonas, 69080-900, Brazil., do Amaral JV; Research Group on Terrestrial Vertebrate Ecology, Mamirauá Institute for Sustainable Development; Tefé, Amazonas, 69553-225, Brazil.; Rede de Pesquisa para Estudos sobre Diversidade, Conservação e Uso da Fauna na Amazônia - RedeFauna; Manaus, Amazonas, 69080-900, Brazil.; Comunidad de Manejo de Fauna Silvestre en la Amazonía y en Latinoamérica - ComFauna; Iquitos, Loreto, 16001, Peru., Messias M; Universidade Federal de Rondonia; Porto Velho, Rondônia, 78900-000, Brazil.; PPGREN - Programa de Pós-Graduação 'Conservação e Uso dos Recursos Naturais and BIONORTE - Programa de Pós-Graduação em Biodiversidade e Biotecnologia da Rede BIONORTE, Universidade Federal de Rondonia; Porto Velho, Rondônia, 78900-000, Brazil., da Silva MNF; Instituto Nacional de Pesquisas da Amazonia; Petrópolis, Manaus - AM, 69067-375, Brazil., Trivedi M; Laboratory for the Conservation of Endangered Species, CSIR-Centre for Cellular and Molecular Biology; Hyderabad, 500007, India., Rossi R; Universidade Federal do Mato Grosso; Boa Esperança, Cuiabá - MT, 78060-900, Brazil., Hrbek T; Universidade Federal do Amazonas, Departamento de Genética, Laboratório de Evolução e Genética Animal (LEGAL); Manaus, Amazonas, 69080-900, Brazil.; Department of Biology, Trinity University; San Antonio, Texas, 78212, USA., Andriaholinirina N; Life Sciences and Environment, Technology and Environment of Mahajanga, University of Mahajanga; Mahajanga, 401, Madagascar., Rabarivola CJ; Life Sciences and Environment, Technology and Environment of Mahajanga, University of Mahajanga; Mahajanga, 401, Madagascar., Zaramody A; Life Sciences and Environment, Technology and Environment of Mahajanga, University of Mahajanga; Mahajanga, 401, Madagascar., Jolly CJ; New York University; New York City, 10012, USA., Phillips-Conroy J; Washington University in St. Louis; St. Louis, Missouri,63130, USA., Wilkerson G; Keeling Center for Comparative Medicine and Research, MD Anderson Cancer Center; Houston, Texas, 77030, USA., Abee C; Yale University; New Haven, Connecticut, 06520, USA., Simmons JH; Keeling Center for Comparative Medicine and Research, MD Anderson Cancer Center; Houston, Texas, 77030, USA., Fernandez-Duque E; Yale University; New Haven, Connecticut, 06520, USA.; Universidad Nacional de Formosa, Argentina Fundacion ECO, Formosa, Argentina., Kanthaswamy S; Arizona State University; Tempe, Arizona, 85281, USA., Shiferaw F; Hawassa University; Hawassa, 005, Ethiopia., Wu D; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences; Kunming, Yunnan, 650223, China., Zhou L; Center for Evolutionary & Organismal Biology, Zhejiang University School of Medicine, Hangzhou, 310058, China., Shao Y; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences; Kunming, Yunnan, 650223, China., Zhang G; Center for Evolutionary & Organismal Biology, Zhejiang University School of Medicine, Hangzhou, 310058, China.; Villum Center for Biodiversity Genomics, Section for Ecology and Evolution, Department of Biology, University of Copenhagen; Copenhagen, DK-2100, Denmark.; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China.; Liangzhu Laboratory, Zhejiang University Medical Center; 1369 West Wenyi Road, Hangzhou, 311121, China.; Women's Hospital, School of Medicine, Zhejiang University; 1 Xueshi Road, Shangcheng District, Hangzhou, 310006, China., Keyyu JD; Tanzania Wildlife Research Institute (TAWIRI), Head Office; P.O.Box 661, Arusha, Tanzania., Knauf S; Institute of International Animal Health/One Health, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health; 17493 Greifswald - Isle of Riems, Germany., Le MD; Department of Environmental Ecology, Faculty of Environmental Sciences, University of Science and Central Institute for Natural Resources and Environmental Studies, Vietnam National University; Hanoi, 100000, Vietnam., Lizano E; Institute of Evolutionary Biology (UPF-CSIC); PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain.; Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona, Barcelona, Spain; Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain., Merker S; Department of Zoology, State Museum of Natural History Stuttgart; 70191 Stuttgart, Germany., Navarro A; Institute of Evolutionary Biology (UPF-CSIC); PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA) and Universitat Pompeu Fabra, Pg. Luís Companys 23, Barcelona, 08010, Spain.; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology; Av. Doctor Aiguader, N88, Barcelona, 08003, Spain.; BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation; C. Wellington 30, Barcelona, 08005, Spain., Batallion T; Bioinformatics Research Centre, Aarhus University; Aarhus, 8000, Denmark., Nadler T; Cuc Phuong Commune; Nho Quan District, Ninh Binh Province, 430000, Vietnam., Khor CC; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome, Singapore 138672, Republic of Singapore., Lee J; Mandai Nature; 80 Mandai Lake Road, Singapore 729826, Republic of Singapore., Tan P; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome, Singapore 138672, Republic of Singapore.; SingHealth Duke-NUS Institute of Precision Medicine (PRISM); Singapore 168582, Republic of Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School; Singapore 168582, Republic of Singapore., Lim WK; SingHealth Duke-NUS Institute of Precision Medicine (PRISM); Singapore 168582, Republic of Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School; Singapore 168582, Republic of Singapore.; SingHealth Duke-NUS Genomic Medicine Centre; Singapore 168582, Republic of Singapore., Kitchener AC; Department of Natural Sciences, National Museums Scotland; Chambers Street, Edinburgh, EH1 1JF, UK.; School of Geosciences, University of Edinburgh; Drummond Street, Edinburgh, EH8 9XP, UK., Zinner D; Cognitive Ethology Laboratory, Germany Primate Center, Leibniz Institute for Primate Research; 37077 Göttingen, Germany.; Department of Primate Cognition, Georg-August-Universität Göttingen; 37077 Göttingen, Germany., Gut I; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST); Baldiri i Reixac 4, 08028, Barcelona, Spain.; Universitat Pompeu Fabra, Pg. Luís Companys 23, Barcelona, 08010, Spain., Melin A; Leibniz Science Campus Primate Cognition; 37077 Göttingen, Germany.; Department of Anthropology & Archaeology and Department of Medical Genetics., Guschanski K; Department of Ecology and Genetics, Animal Ecology, Uppsala University; SE-75236, Uppsala, Sweden.; Alberta Children's Hospital Research Institute; University of Calgary; 2500 University Dr NW T2N 1N4, Calgary, Alberta, Canada., Schierup MH; Bioinformatics Research Centre, Aarhus University; Aarhus, 8000, Denmark., Beck RMD; School of Science, Engineering & Environment, University of Salford; Salford, M5 4WT, United Kingdom., Umapathy G; Academy of Scientific and Innovative Research (AcSIR); Ghaziabad, 201002, India.; Laboratory for the Conservation of Endangered Species, CSIR-Centre for Cellular and Molecular Biology; Hyderabad, 500007, India., Roos C; Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh; Edinburgh, EH8 9XP, UK., Boubli JP; School of Science, Engineering & Environment, University of Salford; Salford, M5 4WT, United Kingdom., Lek M; Gene Bank of Primates and Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research; Kellnerweg 4, 37077 Göttingen, Germany., Sunyaev S; Department of Genetics, Yale School of Medicine; New Haven, Connecticut, 06520, USA.; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School; Boston, Massachusetts, 02115, USA., O'Donnell A; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard; Boston, Massachusetts, 02142, USA.; Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School; Boston, Massachusetts, 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, 02115, USA., Rehm H; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard; Boston, Massachusetts, 02142, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School; Boston, Massachusetts, 02115, USA., Xu J; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA.; Toyota Technological Institute at Chicago; Chicago, Illinois, 60637, USA., Rogers J; Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine; Houston, Texas, 77030, USA., Marques-Bonet T; Institute of Evolutionary Biology (UPF-CSIC); PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain.; CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST); Baldiri i Reixac 4, 08028, Barcelona, Spain.; Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona, Barcelona, Spain; Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA) and Universitat Pompeu Fabra, Pg. Luís Companys 23, Barcelona, 08010, Spain., Kai-How Farh K; Illumina Artificial Intelligence Laboratory, Illumina Inc.; Foster City, California, 94404, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 May 02. Date of Electronic Publication: 2023 May 02.