Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.

Autor: Bata N; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States., Chaikuad A; Buchmann Institute for Molecular Life Sciences, Structural Genomics Consortium, Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany.; Institute for Pharmaceutical Chemistry, Max von Lauestrasse 9, Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany., Bakas NA; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States., Limpert AS; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States., Lambert LJ; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States., Sheffler DJ; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States., Berger LM; Buchmann Institute for Molecular Life Sciences, Structural Genomics Consortium, Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany.; Institute for Pharmaceutical Chemistry, Max von Lauestrasse 9, Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany., Liu G; Chemistry Department, Viva Biotech Ltd., 581 Shen Kuo Road, Shanghai 201203, China., Yuan C; Chemistry Department, Viva Biotech Ltd., 581 Shen Kuo Road, Shanghai 201203, China., Wang L; Chemistry Department, Viva Biotech Ltd., 581 Shen Kuo Road, Shanghai 201203, China., Peng Y; Chemistry Department, Viva Biotech Ltd., 581 Shen Kuo Road, Shanghai 201203, China., Dong J; Chemistry Department, Viva Biotech Ltd., 581 Shen Kuo Road, Shanghai 201203, China., Celeridad M; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States., Layng F; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States., Knapp S; Buchmann Institute for Molecular Life Sciences, Structural Genomics Consortium, Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany.; Institute for Pharmaceutical Chemistry, Max von Lauestrasse 9, Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany.; Translational cancer network DKTK site Frankfurt/Mainz and Frankfurt Cancer Institute (FCI), Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany., Cosford NDP; Cell and Molecular Biology of Cancer Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Jan 27; Vol. 65 (2), pp. 1352-1369. Date of Electronic Publication: 2021 Nov 22.

Mitochondrial tRNA^Glu 14693A > G Mutation, an "Enhancer" to the Phenotypic Expression of Leber's Hereditary Optic Neuropathy.

Autor: Jin, Lihao^1,2,3 (AUTHOR), Gan, Dingyi^1,2,3 (AUTHOR), He, Wentao^1,2,3 (AUTHOR), Wu, Na^1,3 (AUTHOR), Xiang, Shuchenlu^1,3 (AUTHOR), Wei, Yinsheng^1,2,3 (AUTHOR), Eriani, Gilbert⁴ (AUTHOR), Ji, Yanchun^2,3 (AUTHOR) yanchunji@zju.edu.cn, Guan, Min‐Xin^1,2,3 (AUTHOR) gminxin88@zju.edu.cn, Wang, Meng^1,2,3 (AUTHOR) mengwang@zju.edu.cn

Publikováno v: Advanced Science. 11/6/2024, Vol. 11 Issue 41, p1-14. 14p.

Autophagy in Cancer: Regulation by Small Molecules.

Autor: Limpert AS; NCI Designated Cancer Center, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA; These authors contributed equally., Lambert LJ; NCI Designated Cancer Center, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA; These authors contributed equally., Bakas NA; NCI Designated Cancer Center, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Bata N; NCI Designated Cancer Center, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Brun SN; Department of Molecular and Cell Biology, The Salk Institute for Biological Studies, San Diego, La Jolla, CA, USA., Shaw RJ; Department of Molecular and Cell Biology, The Salk Institute for Biological Studies, San Diego, La Jolla, CA, USA., Cosford NDP; NCI Designated Cancer Center, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. Electronic address: ncosford@sbpdiscovery.org.

Publikováno v: Trends in pharmacological sciences [Trends Pharmacol Sci] 2018 Dec; Vol. 39 (12), pp. 1021-1032.

Blockage of Autophagy for Cancer Therapy: A Comprehensive Review.

Autor: Hassan, Ahmed Mostafa Ibrahim Abdelrahman¹ (AUTHOR) xpchen@um.edu.mo, Zhao, Yuxin¹ (AUTHOR), Chen, Xiuping^1,2 (AUTHOR), He, Chengwei^1,2 (AUTHOR) chengweihe@um.edu.mo

Publikováno v: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 13, p7459. 45p.

Classification of wheat genotypes on the basis of morphological and physiological traits in combination with spot blotch resistance under terai sub-Himalayan region.

Autor: Kishore, Ponaganti Shiva¹, Roy, Suvendu Kumar¹ suvendukumarroy@gmail.com, Das, Saikat², Ali, Basid¹, Vishnupriya, S.¹, Hijam, Lakshmi¹, Chakraborty, Moumita¹, Dutta, Puspendu³, Mandal, Rupsanatan⁴, Kundu, Avijit⁵, Rout, Sanghamitra⁶

Publikováno v: Electronic Journal of Plant Breeding. Jun2024, Vol. 15 Issue 2, p313-324. 12p.