Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Basvoju A. Bhanu Prasad"'
Autor:
Gilbert R. Lee, Florian L. Muller, John M. Asara, Todd M. Link, Federica Pisaneschi, Barbara Czako, Y. Alan Wang, Duoli Sun, William G. Bornmann, Yu Hsi Lin, Ronald A. DePinho, Paul G. Leonard, David Maxwell, Maria Emilia Di Francesco, Naima Hammoudi, Nikunj Satani, Basvoju A. Bhanu Prasad, Zhenghong Peng
Publikováno v:
Nature chemical biology
Despite being crucial for energy generation in most forms of life, few if any microbial antibiotics specifically inhibit glycolysis. To develop a specific inhibitor of the glycolytic enzyme enolase 2 (ENO2) for the treatment of cancers with deletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7fe16601d682c58a159c49b4a33d58
https://doi.org/10.1038/nchembio.2195
https://doi.org/10.1038/nchembio.2195
Autor:
William G. Bornmann, Basvoju A. Bhanu Prasad, Paul T. Schuber, Ashutosh Pal, Bharat B. Aggarwal, Sahdeo Prasad, Bokyung Sung
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:435-439
A gram scale synthesis of the glucuronide metabolites of curcumin were completed in four steps. The newly synthesized curcumin glucuronide compounds 2 and 3 along with curcumin 1 were tested and their anti-proliferative effects against KBM-5, Jurkat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b63dc4a6e9181804017288a752740d
https://doi.org/10.1016/j.bmc.2013.11.006
https://doi.org/10.1016/j.bmc.2013.11.006
Publikováno v:
Tetrahedron Letters. 54:5555-5557
The C1–C6 region of the potent cytotoxic agent psymberin has been synthesized. The key transformations of the synthesis are an auxiliary-controlled addition of a Sn(II)-glycolate enolate to an aldehyde to yield the anti -aldol product and transform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92dea9d60abf110ed48dd2d22ef66826
https://doi.org/10.1016/j.tetlet.2013.05.153
https://doi.org/10.1016/j.tetlet.2013.05.153
Autor:
Basvoju A. Bhanu Prasad, Juri G. Gelovani, Duoli Sun, Zhenghong Peng, William G. Bornmann, Paul T. Schuber, Wai Kwan Alfred Yung, Yunming Ying, David Maxwell
Publikováno v:
Tetrahedron. 70(4)
A virtual library of 54 inositol analog mimics of In(1,4,5)P3 has been docked, scored, and ranked within the binding site of human inositol 1,4,5-trisphosphate 3-kinase A (IP3-3KA). Chemical synthesis of the best scoring structure that also met dista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a856450f659a9d060150f8365cd0010
https://pubmed.ncbi.nlm.nih.gov/25110363
https://pubmed.ncbi.nlm.nih.gov/25110363
Autor:
David Maxwell, Duoli Sun, Alexander Levitzki, Nicholas J. Donato, Dongmei Han, William G. Bornmann, Basvoju A. Bhanu Prasad, Yunming Ying, Paul T. Schuber, Zhenghong Peng, Matthew A. Young, Shimei Wang, H. D. Hollis Showalter, Ashutosh Pal, Vaibhav Kapuria, Liwei Gao, Moshe Talpaz
Publikováno v:
Bioorganicmedicinal chemistry. 22(4)
A series of degrasyn-like symmetrical compounds have been designed, synthesized, and screened against B cell malignancy (multiple myeloma, mantle cell lymphoma) cell lines. The lead compounds T5165804 and CP2005 showed higher nanomolar potency agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2aa35805cbbd5ebf2c7cefcd91b459
https://pubmed.ncbi.nlm.nih.gov/24457091
https://pubmed.ncbi.nlm.nih.gov/24457091
Autor:
Diana V. Martin, David Maxwell, Basvoju A. Bhanu Prasad, Duoli Sun, Zhenghong Peng, William G. Bornmann
We report the synthesis of a macrocycle utilizing a novel framework of standard amino acids in combination with subunits that we have named as Linked Amino Acid Mimetics (LAAM's). Macrocycles based on the LAAM concept provide both a peptide targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1090ef8f02cb3ef05b3c4aa78ae50161
https://europepmc.org/articles/PMC4125026/
https://europepmc.org/articles/PMC4125026/
Autor:
David Maxwell, Garth Powis, Diana V. Martin, William G. Bornmann, Basvoju A. Bhanu Prasad, Paul T. Schuber, David J. Yang, Liwei Guo, Hiroaki Kurihara, Dongmei Han, Zhenghong Peng, Duoli Sun, Juri G. Gelovani
An improved method for the synthesis of 17β-hydroxy-16α-iodo-wortmannin along with the first synthesis of 17β-hydroxy-16α-iodoPX866 and [(131)I] radiolabeled 17β-hydroxy-16α-[(131)I]iodo-wortmannin, as potential PET tracers for PI3K was also de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebd8bfcb009d2a531a00faf1b0cb446
https://europepmc.org/articles/PMC3960976/
https://europepmc.org/articles/PMC3960976/
Autor:
Basvoju A. Bhanu Prasad, David Maxwell, Milind Javle, William G. Bornmann, Mingxin Zuo, Zhenghong Peng
Publikováno v:
Cancer Research. 74:5361-5361
Background: RecQ helicases are a ubiquitous family of DNA unwinding enzymes involved in the maintenance of chromosome stability. RecQ1 helicase genomic variations have an important prognostic role and represents a therapeutic target in pancreatic can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34adf84c680add79e5ed53caec276536
https://doi.org/10.1158/1538-7445.am2014-5361
https://doi.org/10.1158/1538-7445.am2014-5361