Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Basudev, Paudyal"'
Autor:
Eleni Vatzia, Basudev Paudyal, Barbara Dema, Brigid Veronica Carr, Ehsan Sedaghat-Rostami, Simon Gubbins, Bhawna Sharma, Elliot Moorhouse, Susan Morris, Marta Ulaszewska, Ronan MacLoughlin, Francisco J. Salguero, Sarah C. Gilbert, Elma Tchilian
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract Current influenza vaccines are strain-specific and require frequent updates to combat new strains, making a broadly protective influenza vaccine (BPIV) highly desirable. A promising strategy is to induce T-cell responses against internal pro
Externí odkaz:
https://doaj.org/article/ca1c422f5b0b422cbcff2e60d8a41134
Autor:
Basudev Paudyal, Elliot Moorhouse, Bhawna Sharma, Michael Dodds, Victor Nguyen, Mark Milad, Elma Tchilian
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Assessing the pharmacokinetics of monoclonal antibodies (mAbs) in relevant animal models is essential for designing improved formulations and developing mAb delivery platforms. We have established the pig, a large natural host animal for influenza wi
Externí odkaz:
https://doaj.org/article/d50d1aa8a73a47f5b53f75f43ee6494f
Autor:
Andrew Muir, Basudev Paudyal, Selma Schmidt, Ehsan Sedaghat-Rostami, Soumendu Chakravarti, Sonia Villanueva-Hernández, Katy Moffat, Noemi Polo, Nicos Angelopoulos, Anna Schmidt, Matthias Tenbusch, Graham Freimanis, Wilhelm Gerner, Arianne C Richard, Elma Tchilian
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1011910 (2024)
The pig is a natural host for influenza viruses and integrally involved in virus evolution through interspecies transmissions between humans and swine. Swine have many physiological, anatomical, and immunological similarities to humans, and are an ex
Externí odkaz:
https://doaj.org/article/bc240ee05da74cccb8d07006bf4911f8
Autor:
Alistair Noble, Basudev Paudyal, John C. Schwartz, William Mwangi, Danish Munir, Elma Tchilian, John A. Hammond, Simon P. Graham
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cattle possess three IgG subclasses. However, the key immune functions, including complement and NK cell activation, and enhancement of phagocytosis, are not fully described for bovine IgG1, 2 and 3. We produced chimeric monoclonal antibodies (mAbs)
Externí odkaz:
https://doaj.org/article/c125402771454d8cb3a729521fe59da9
Autor:
Adam McNee, Daryll Vanover, Pramila Rijal, Basudev Paudyal, Fabian Z. X. Lean, Ronan MacLoughlin, Alejandro Núñez, Alain Townsend, Philip J. Santangelo, Elma Tchilian
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Monoclonal antibodies (mAbs) can be used to complement immunization for the therapy of influenza virus infection. We have established the pig, a natural large animal host for influenza A, with many physiological, immunological, and anatomical similar
Externí odkaz:
https://doaj.org/article/1b9abc19367647599d0c9f71a713120b
Autor:
Eleni Vatzia, Katherine Feest, Adam McNee, Tanuja Manjegowda, B. Veronica Carr, Basudev Paudyal, Tiphany Chrun, Emmanuel A. Maze, Amy Mccarron, Susan Morris, Helen E. Everett, Ronan MacLoughlin, Francisco J. Salguero, Teresa Lambe, Sarah C. Gilbert, Elma Tchilian
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract There is an urgent need for influenza vaccines providing broader protection that may decrease the need for annual immunization of the human population. We investigated the efficacy of heterologous prime boost immunization with chimpanzee ade
Externí odkaz:
https://doaj.org/article/360ba21cac734dc29a1a9ee1b34725d4
Autor:
Tiphany Chrun, Emmanuel A. Maze, Kelly J. Roper, Eleni Vatzia, Basudev Paudyal, Adam McNee, Veronica Martini, Tanuja Manjegowda, Graham Freimanis, Adrian Silesian, Noemi Polo, Becky Clark, Emily Besell, Georges Booth, Brigid Veronica Carr, Matthew Edmans, Alejandro Nunez, Surapong Koonpaew, Nanchaya Wanasen, Simon P. Graham, Elma Tchilian
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Porcine respiratory disease is multifactorial and most commonly involves pathogen co-infections. Major contributors include swine influenza A (swIAV) and porcine reproductive and respiratory syndrome (PRRSV) viruses. Experimental co-infection studies
Externí odkaz:
https://doaj.org/article/c461564e424f407087561ce15d06212d
Autor:
Anna Schmidt, Basudev Paudyal, Sonia Villanueva-Hernández, Adam Mcnee, Eleni Vatzia, Brigid Veronica Carr, Selma Schmidt, Amy Mccarron, Veronica Martini, Silke Schroedel, Christian Thirion, Ryan Waters, Francisco J. Salguero, Wilhelm Gerner, Matthias Tenbusch, Elma Tchilian
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
T cell responses directed against highly conserved viral proteins contribute to the clearance of the influenza virus and confer broadly cross-reactive and protective immune responses against a range of influenza viruses in mice and ferrets. We examin
Externí odkaz:
https://doaj.org/article/7a124e0b2d554bd1b327bae9c7f98cfe
Autor:
Basudev Paudyal, William Mwangi, Pramila Rijal, John C. Schwartz, Alistair Noble, Andrew Shaw, Joshua E. Sealy, Marie Bonnet-Di Placido, Simon P. Graham, Alain Townsend, John A. Hammond, Elma Tchilian
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The pig is an important agricultural species and powerful biomedical model. We have established the pig, a large natural host animal for influenza with many physiological similarities to humans, as a robust model for testing the therapeutic potential
Externí odkaz:
https://doaj.org/article/7dbceeee9330479480e599f351e6d1f3
Autor:
Basudev Paudyal, Adam McNee, Pramila Rijal, B. Veronica Carr, Alejandro Nunez, John McCauley, Rodney S. Daniels, Alain R. Townsend, John A. Hammond, Elma Tchilian
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
We have established the pig, a large natural host animal for influenza, with many physiological similarities to humans, as a robust model for testing the therapeutic potential of monoclonal antibodies (mAbs). In this study we demonstrated that prophy
Externí odkaz:
https://doaj.org/article/95f630cd393544099cef9829a0765926