Differential gradients of immunotherapy vs targeted therapy efficacy according to the sun-exposure pattern of the site of occurrence of primary melanoma: a multicenter prospective cohort study (MelBase)

Autor: David Russo, Stéphane Dalle, Olivier Dereure, Laurent Mortier, Sophie Dalac-Rat, Caroline Dutriaux, Marie-Thérèse Leccia, Delphine Legoupil, Henri Montaudié, Eve Maubec, Julie De Quatrebarbes, Jean-Philippe Arnault, Florence Granel Brocard, Philippe Saïag, Brigitte Dreno, Clara Allayous, Bastien Oriano, Wendy Lefevre, Céleste Lebbé, Lise Boussemart

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

BackgroundThe tumor mutational burden (TMB) is high in melanomas owing to UV-induced oncogenesis. While a high TMB is a predictive biomarker of response to PD-1 inhibitors, it may be associated with the rise of resistant clones to targeted therapy ov

Externí odkaz: https://doaj.org/article/f844a1fc7d06416ea3d2882e024c7f02

Prospective external validation of biomarkers to predict acute graft-versus-host disease severity

Autor: Marie Robin, Raphael Porcher, David Michonneau, Laetitia Taurines, Flore Sicre de Fontbrune, Aliénor Xhaard, Bastien Oriano, Aurélien Sutra Del Galy, Régis Peffault de Latour, Gérard Socié, Marie-Hélène Schlageter

Publikováno v: Blood advances. 6(16)

Acute graft-versus-host disease (GVHD) is still the major contributor to comorbidities and mortality after allogeneic hematopoietic stem cell transplantation. The use of plasmatic biomarkers to predict early outcomes has been advocated in the past de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0abdf1491458d62e14c9548fae6c38
https://pubmed.ncbi.nlm.nih.gov/35667096

Risque de toxicité immunomédiée chez les patients avec antécédents d’auto-immunité traités par inhibiteurs de checkpoint pour un mélanome métastatique

Autor: Julie De Quatrebarbes, Florence Granel Brocard, Sabiha Trabelsi, P.-E. Stoebner, Eve Maubec, Clara Allayous, Thierry Lesimple, Jean-Philippe Arnault, Sophie Dalac, Florence Brunet Possenti, Delphine Legoupil, Léo Plaçais, Henri Montaudié, Brigitte Dreno, F. Aubin, Céleste Lebbé, Olivier Dereure, Laurent Mortier, S. Dalle, Philippe Saiag, Jean-Jacques Grob, Bastien Oriano, Caroline Dutriaux

Publikováno v: Annales de Dermatologie et de Vénéréologie - FMC. 1:A74-A75

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::326a551b1dedf31befa3e403e0465b91
https://doi.org/10.1016/j.fander.2021.09.472

Efficacy and tolerance of systemic therapies in metastatic melanoma of unknown primary versus known cutaneous: A multicenter retrospective study from the MelBase French Cohort

Autor: Perrine Rousset, Stéphane Dalle, Laurent Mortier, Olivier Dereure, Sophie Dalac, Caroline Dutriaux, Marie Thérèse Leccia, Delphine Legoupil, Vincent Descamps, Julie De Quatrebarbes, Jean-Jacques Grob, Philippe Saiag, Eve Maubec, Pierre-Emmanuel Stoebner, Florence Granel Brocard, Jean-Philippe Arnault, Clara Allayous, Bastien Oriano, Celeste Lebbe, Henri Montaudie

Publikováno v: Journal of Clinical Oncology. 40:9556-9556

9556 Background: Melanoma of unknown primary (MUP) account for 3% of all melanomas. Clinical outcome of advanced MUP in the era of novel therapies including immunotherapies (ICI) and targeted therapies (TT) have been only scarcely studied, whereas a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40f55e9b1c5bc74d21399d89f354f7af
https://doi.org/10.1200/jco.2022.40.16_suppl.9556

Impact of radiotherapy administered simultaneously with systemic treatment in patients with melanoma brain metastases within MelBase, a French multicentric prospective cohort

Autor: Stéphane Dalle, Raphaël Porcher, Thierry Lesimple, Marie-Thérèse Leccia, Jean-Philippe Lacour, Sophie Dalac, D. Legoupil, Pauline Tétu, Sameh Mohamed, A. Ballon, Florence Brunet-Possenti, Céleste Lebbé, Clara Allayous, Laurent Mortier, François Aubin, Julie De Quatrebarbes, Pierre-Emmanuel Stoebner, Caroline Dutriaux, Bastien Oriano, Brigitte Dréno, Bernard Guillot, Philippe Saiag, Marie Beylot-Barry

Publikováno v: European Journal of Cancer
European Journal of Cancer, Elsevier, 2019, 112, pp.38-46. ⟨10.1016/j.ejca.2019.02.009⟩
European Journal of Cancer, 2019, 112, pp.38-46. ⟨10.1016/j.ejca.2019.02.009⟩

International audience; Background: Melanoma brain metastases (MBMs) are historically associated with poor prognosis. Radiation therapy is conventionally associated with a high local control rate. Development of targeted therapy and immunotherapy has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4740f4de3a0995fc1c93c6462b8f58e5
https://hal.umontpellier.fr/hal-02872129/file/S0959804919301716.pdf