Výsledky vyhledávání - "Bastien Mangeat"

Akademický článek

BRB-seq: ultra-affordable high-throughput transcriptomics enabled by bulk RNA barcoding and sequencing

Autor: Daniel Alpern, Vincent Gardeux, Julie Russeil, Bastien Mangeat, Antonio C. A. Meireles-Filho, Romane Breysse, David Hacker, Bart Deplancke

Publikováno v: Genome Biology, Vol 20, Iss 1, Pp 1-15 (2019)

Abstract Despite its widespread use, RNA-seq is still too laborious and expensive to replace RT-qPCR as the default gene expression analysis method. We present a novel approach, BRB-seq, which uses early multiplexing to produce 3′ cDNA libraries fo

Externí odkaz: https://doaj.org/article/e289bfac90334ee397207a5add15836d

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Akademický článek

Disparate temperature-dependent virus-host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium.

Publikováno v: PLoS Biology, Vol 19, Iss 3, p e3001158 (2021)

Since its emergence in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally and become a major public health burden. Despite its close phylogenetic relationship to SARS-CoV, SARS-CoV-2 exhibits increased hum

Externí odkaz: https://doaj.org/article/4947e0abbc4d4c3a9adf0701b3b2f770

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Akademický článek

Inhibition of HIV-1 replication by balsamin, a ribosome inactivating protein of Momordica balsamina.

Autor: Inderdeep Kaur, Munish Puri, Zahra Ahmed, Fabien P Blanchet, Bastien Mangeat, Vincent Piguet

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e73780 (2013)

Ribosome-inactivating proteins (RIPs) are endowed with several medicinal properties, including antiviral activity. We demonstrate here that the recently identified type I RIP from Momordica balsamina also possesses antiviral activity, as determined b

Externí odkaz: https://doaj.org/article/89c9da2cc0f34cfe9ed4baff0c38c0df

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Akademický článek

Quantitative multicolor super-resolution microscopy reveals tetherin HIV-1 interaction.

Autor: Martin Lehmann, Susana Rocha, Bastien Mangeat, Fabien Blanchet, Hiroshi Uji-I, Johan Hofkens, Vincent Piguet

Publikováno v: PLoS Pathogens, Vol 7, Iss 12, p e1002456 (2011)

Virus assembly and interaction with host-cell proteins occur at length scales below the diffraction limit of visible light. Novel super-resolution microscopy techniques achieve nanometer resolution of fluorescently labeled molecules. The cellular res

Externí odkaz: https://doaj.org/article/c972fbdf29cb400091b57aedba59c2a3

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Akademický článek

HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation.

Autor: Bastien Mangeat, Gustavo Gers-Huber, Martin Lehmann, Madeleine Zufferey, Jeremy Luban, Vincent Piguet

Publikováno v: PLoS Pathogens, Vol 5, Iss 9, p e1000574 (2009)

Host cells impose a broad range of obstacles to the replication of retroviruses. Tetherin (also known as CD317, BST-2 or HM1.24) impedes viral release by retaining newly budded HIV-1 virions on the surface of cells. HIV-1 Vpu efficiently counteracts

Externí odkaz: https://doaj.org/article/44a0c442744b443baf920336e2d7e616

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Akademický článek

Model structure of human APOBEC3G.

Autor: Kun-Lin Zhang, Bastien Mangeat, Millan Ortiz, Vincent Zoete, Didier Trono, Amalio Telenti, Olivier Michielin

Publikováno v: PLoS ONE, Vol 2, Iss 4, p e378 (2007)

APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G) has antiretroviral activity associated with the hypermutation of viral DNA through cytosine deamination. APOBEC3G has two cytosine deaminase (CDA) domains; the catalytical

Externí odkaz: https://doaj.org/article/fb0246ab8b2747609402aa97536c7f8f

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Akademický článek

Molecular mechanism of hepcidin deficiency in a patient with juvenile hemochromatosis

Autor: Alexandra Rideau, Bastien Mangeat, Thomas Matthes, Didier Trono, Photis Beris

Publikováno v: Haematologica, Vol 92, Iss 1 (2007)

We describe a point mutation creating an additional ATG codon in the 5′ untranslated region (UTR) of the HAMP gene, in a patient with juvenile hemochromatosis. By transient in vitro transfection studies, we provide evidence that the additional ATG

Externí odkaz: https://doaj.org/article/e6600fcbc0a64c9fa74ce4a957cdaf46

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