Generation of human induced pluripotent stem cell lines from four unrelated healthy control donors carrying European genetic background

Autor: Aurore Girardeau, Diane Atticus, Robin Canac, Bastien Cimarosti, Amandine Caillaud, Caroline Chariau, Floriane Simonet, Bertrand Cariou, Flavien Charpentier, Jean-Baptiste Gourraud, Vincent Probst, Nadjet Belbachir, Laurence Jesel, Patricia Lemarchand, Julien Barc, Richard Redon, Nathalie Gaborit, Guillaume Lamirault

Publikováno v: Stem Cell Research, Vol 59, Iss , Pp 102647- (2022)

Four human induced pluripotent stem cell (hiPSC) lines have been generated from healthy control European donors, and validated. This resource represents a useful tool for stem cell-based research, as references for developmental studies and disease m

Externí odkaz: https://doaj.org/article/e451cd47ad734a8bbbb3a51ae1564c13

Generation of three human induced pluripotent stem cell lines with IRX5 knockout and knockin genetic editions using CRISPR-Cas9 system

Autor: Robin Canac, Amandine Caillaud, Bastien Cimarosti, Aurore Girardeau, Hanan Hamamy, Bruno Reversade, Carine Bonnard, Zeina R. Al Sayed, Laurent David, Jeremie Poschmann, Patricia Lemarchand, Guillaume Lamirault, Nathalie Gaborit

Publikováno v: Stem Cell Research, Vol 58, Iss , Pp 102627- (2022)

Studies on animal models have shown that Irx5 is an important regulator of cardiac development and that it regulates ventricular electrical repolarization gradient in the adult heart. Mutations in IRX5 have also been linked in humans to cardiac condu

Externí odkaz: https://doaj.org/article/a5200d83fcab486da903e7e399073f5b

A consistent arrhythmogenic trait in Brugada syndrome cellular phenotype

Autor: Zeina R. Al Sayed, Mariam Jouni, Jean‐Baptiste Gourraud, Nadjet Belbachir, Julien Barc, Aurore Girardeau, Virginie Forest, Aude Derevier, Anne Gaignerie, Caroline Chariau, Bastien Cimarosti, Robin Canac, Pierre Olchesqui, Eric Charpentier, Jean‐Jacques Schott, Richard Redon, Isabelle Baró, Vincent Probst, Flavien Charpentier, Gildas Loussouarn, Kazem Zibara, Guillaume Lamirault, Patricia Lemarchand, Nathalie Gaborit

Publikováno v: Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)

Externí odkaz: https://doaj.org/article/2317e090f55f4c2ab06747c2064a68e2

Abstract 13258: Transcriptomic Remodeling of Brugada Syndrome Arises During in vitro Cardiac Development

Autor: Bastien Cimarosti, Robin Canac, Virginie Forest, Aurore Girardeau, Nathalie Gaborit, Patricia Lemarchand, Richard Redon, Guillaume Lamirault

Publikováno v: Circulation. 144

Introduction: Recent genetic data suggest that abnormal cardiac development participate to the pathogenesis of Brugada Syndrome (BrS), a rare inherited arrhythmia responsible for sudden cardiac death in young adults. In vitro cardiac differentiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::784caf144ad9c724c7065a0797e92a86
https://doi.org/10.1161/circ.144.suppl_1.13258

A consistent arrhythmogenic trait in Brugada syndrome cellular phenotype

Autor: Aude Derevier, Robin Canac, Isabelle Baró, Guillaume Lamirault, Vincent Probst, Jean-Jacques Schott, Anne Gaignerie, Aurore Girardeau, Richard Redon, Julien Barc, Flavien Charpentier, Bastien Cimarosti, Patricia Lemarchand, Nathalie Gaborit, Virginie Forest, Zeina R Al Sayed, Nadjet Belbachir, Mariam Jouni, Gildas Loussouarn, Kazem Zibara, Pierre Olchesqui, Eric Charpentier, Jean-Baptiste Gourraud, Caroline Chariau

Publikováno v: Clinical and Translational Medicine
Clinical and Translational Medicine, Heidelberg : Springer-Verlag, 2021, 11 (6), ⟨10.1002/ctm2.413⟩
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Clinical and Translational Medicine, 2021, 11 (6), ⟨10.1002/ctm2.413⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb7cbaf4641998c180eda4f1bac67c2
https://doi.org/10.1002/ctm2.413