Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Bastianella Perazzona"'
Autor:
Yu Hsi Lin, Bastianella Perazzona, Ralph B. Arlinghaus, Xiaoping Sun, Xiaohong Leng, Sandip N. Chakraborty
Publikováno v:
Genes & Cancer
Recent studies suggest that JAK2 serves as a novel therapeutic target in Bcr-Abl+ chronic myelogenous leukemia (CML). We have reported the existence of an HSP90- associated high molecular weight network complex (HMWNC) that is composed of HSP90 clien
Autor:
Ralph B. Arlinghaus, Xiaoping Sun, Bastianella Perazzona, Waldemar Priebe, Sandip N. Chakraborty, Ravi Bhatia, Ajoy K. Samanta, Hardik Modi
Publikováno v:
Leukemia
Despite the success of imatinib mesylate (IM) in the early chronic phase of chronic myeloid leukemia (CML), patients are resistant to IM and other kinase inhibitors in the later stages of CML. Our findings indicate that inhibition of Janus kinase 2 (
Publikováno v:
Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2004, 24 (40), pp.8823-8. ⟨10.1523/JNEUROSCI.4542-03.2004⟩
Journal of Neuroscience, Society for Neuroscience, 2004, 24 (40), pp.8823-8. ⟨10.1523/JNEUROSCI.4542-03.2004⟩
InDrosophila,the transcription factor cAMP response element-binding protein 2 (dCREB2) has been reported to modulate the formation of long-term olfactory memory (LTM). Overexpression of a repressor isoform of CREB (dCREB2-b) under the control of a he
Autor:
Bastianella Perazzona, John L. Spudich
Publikováno v:
Journal of Bacteriology. 181:5676-5683
The two transducers in the phototaxis system of the archaeon Halobacterium salinarum , HtrI and HtrII, are methyl-accepting proteins homologous to the chemotaxis transducers in eubacteria. Consensus sequences predict three glutamate pairs containing
Publikováno v:
Journal of Bacteriology. 178:6475-6478
The phototaxis receptor sensory rhodopsin I (SRI) transmits signals through a membrane-bound transducer protein, HtrI. The genes for the receptor and transducer, sopI and htrI, respectively, are normally cotranscribed; however, previous work has esta
Publikováno v:
Blood. 118:4412-4412
Abstract 4412 Chronic myeloid leukemia (CML) is a hematological disease caused by the fusion protein Bcr-Abl tyrosine kinase. Development of the tyrosine kinase inhibitor Imatinib Mesylate (IM) has significantly improved the long-term survival of ear
Autor:
Robert Bittman, Tessa L. Holyoake, Danilo Perrotti, Joshua J. Oaks, Ravi Bhatia, Peter Hokland, Charlene Mao, Ramasamy Santhanam, Guido Marcucci, Michael A. Caligiuri, Bin Zhang, Carolyn Paisie, Anna M. Eiring, Christopher J. Walker, Ralph B. Arlinghaus, Denis-Claude Roy, Ching-Shih Chen, Jason G. Harb, Jorge E. Cortes, Yihui Ma, Paolo Neviani, Stefano Volinia, Bastianella Perazzona, Claudia S. Huettner
Publikováno v:
Cancer Research. 71:LB-109
Background: The success of tyrosine kinase inhibitors (TKIs) depends on the addiction of Philadelphia-positive (Ph+) CML progenitors to BCR-ABL1 kinase activity. However, CML quiescent hematopoietic stem cells (HSC) are TKI-resistant and represent an
Autor:
Sandip N. Chakraborty, Bastianella Perazzona, Ravi Bhatia, Ralph B. Arlinghaus, Ajoy K. Samanta, Hardik Modi, Xiaoping Sun
Publikováno v:
Blood. 116:1220-1220
Abstract 1220 Despite the success of imatinib mesylate (IM), complete molecular remission is difficult to achieve in IM-treated CML patients. After continuing treatment with IM, a population of leukemic stem/progenitor cells remains, which are insens
Autor:
Yihui Ma, Robert Bittman, Danilo Perrotti, Tessa L. Holyoake, Bin Zhang, Denis-Claude Roy, Ramasamy Santhanam, Ralph B. Arlinghaus, Christopher J. Walker, Ravi Bhatia, Charlene Mao, Jorge E. Cortes, Claudia S. Huettner, Paolo Neviani, Peter Hokland, Ching-Shih Chen, Carolyn Paisie, Michael A. Caligiuri, Anna M. Eiring, Joshua J. Oaks, Guido Marcucci, Jason G. Harb, Stefano Volinia, Bastianella Perazzona
Publikováno v:
Blood. 116:515-515
Abstract 515 The success of tyrosine kinase inhibitors as first line therapy for t(9;22) Chronic Myelogenous Leukemia (CML) depends on the addiction that Philadelphia-positive (Ph+) hematopoietic progenitors, but not quiescent Ph+ stem cells, have fo
Publikováno v:
Blood. 112:3210-3210
Bcr-Abl acquires its transforming ability through its up-regulated Abl tyrosine kinase activity. Bcr is a phosphoprotein with a novel serine/threonine kinase activity encoded by its first exon. Over-expression of BCR in K562 cells produces a phosphos