Anti-nuclear autoantibodies in the general German population: prevalence and lack of association with selected cardiovascular and metabolic disorders—findings of a multicenter population-based study

Autor: Manas K. Akmatov, Nadja Röber, Wolfgang Ahrens, Dieter Flesch-Janys, Julia Fricke, Halina Greiser, Kathrin Günther, Rudolf Kaaks, Yvonne Kemmling, Bastian Krone, Jakob Linseisen, Christa Meisinger, Susanne Moebus, Nadia Obi, Carlos A. Guzman, Karsten Conrad, Frank Pessler

Publikováno v: Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-9 (2017)

Abstract Background We determined the prevalence of anti-nuclear autoantibodies (ANAs) in the German adult population and examined the association between ANAs and cardiovascular and metabolic disorders. Methods We used data and blood samples from th

Externí odkaz: https://doaj.org/article/2ad2bd40d63c47f5bc7c712e0f133939

Treatment pattern of type 2 diabetes differs in two German regions and with patients' socioeconomic position.

Autor: Teresa Tamayo, Heiner Claessen, Ina-Maria Rückert, Werner Maier, Michaela Schunk, Christine Meisinger, Andreas Mielck, Rolf Holle, Barbara Thorand, Maria Narres, Susanne Moebus, Amir-Abbas Mahabadi, Noreen Pundt, Bastian Krone, Uta Slomiany, Raimund Erbel, Karl-Heinz Jöckel, Wolfgang Rathmann, Andrea Icks

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e99773 (2014)

BACKGROUND: Diabetes treatment may differ by region and patients' socioeconomic position. This may be particularly true for newer drugs. However, data are highly limited. METHODS: We examined pooled individual data of two population-based German stud

Externí odkaz: https://doaj.org/article/8eaed0f003c84577840e1761627bc981

Integration of Murine and Human Studies for Mapping Periodontitis Susceptibility

Autor: Bastian Krone, Peter Hoffmann, Andre Franke, N. van der Velde, A.G. Uitterlinden, S. Offenbacher, Matthias Laudes, Y.H. Haddad, Klaus Berger, Thomas Kocher, Richard Mott, Y. Salaymeh, Maya Botzman, Arne S. Schaefer, Henrik Dommisch, Bruno G. Loos, Kimon Divaris, L. de Groot, Matthias Munz, R. Qabaja, Jürgen Wellmann, Fuad A. Iraqi, E. Wiess, Aysar Nashef, Irit Gat-Viks, Wolfgang Lieb

Publikováno v: Journal of Dental Research 97 (2018) 5
Journal of Dental Research, 97(5), 537-546. SAGE Publications Inc.
Journal of Dental Research, 97(5), 537-546
Nashef, A, Qabaja, R, Salaymeh, Y, Botzman, M, Munz, M, Dommisch, H, Krone, B, Hoffmann, P, Wellmann, J, Laudes, M, Berger, K, Kocher, T, Loos, B, van der Velde, N, Uitterlinden, A G, de Groot, L C P G M, Franke, A, Offenbacher, S, Lieb, W, Divaris, K, Mott, R, Gat-Viks, I, Wiess, E, Schaefer, A, Iraqi, F A & Haddad, Y H 2018, ' Integration of murine and human studies for mapping periodontitis susceptibility ', Journal of Dental Research, vol. 97, no. 5, pp. 537-546 . https://doi.org/10.1177/0022034517744189
Journal of dental research, 97(5), 537-546. SAGE Publications Inc.
Journal of Dental Research, 97(5), 537-546. SAGE Publishing

Periodontitis is one of the most common inflammatory human diseases with a strong genetic component. Due to the limited sample size of available periodontitis cohorts and the underlying trait heterogeneity, genome-wide association studies (GWASs) of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df8b51edad4b31a18e322b1562acfd7
https://research.wur.nl/en/publications/integration-of-murine-and-human-studies-for-mapping-periodontitis

The PF4/PPBP/CXCL5 Gene Cluster Is Associated with Periodontitis

Autor: Gesa M. Richter, Matthias Laudes, Arne S. Schaefer, Jürgen Wellmann, Ervin I. Weiss, Thomas Kocher, Fuad A. Iraqi, Kimon Divaris, Klaus Berger, Wolfgang Lieb, S. Jepsen, Henrik Dommisch, Bastian Krone, Matthias Munz, Andre Franke, Stefan Schreiber, S. Offenbacher, Per Hoffman, Ariel Shusterman, Yael Houri-Haddad

Periodontitis is a common dysbiotic inflammatory disease with an estimated heritability of 50%. Due to the limited sample size of available periodontitis cohorts and the underlying trait heterogeneity, genome-wide association studies (GWAS) of chroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a58434a1fdfcffb81eecac1d4e85e31
https://europepmc.org/articles/PMC5502958/

A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis

Autor: Bastian Krone, Peter Eickholz, Birte Holtfreter, Klaus Berger, S. Jepsen, G. her Saruhan-Direskeneli, Henrik Dommisch, Christina Willenborg, Amr H. Sawalha, Corinna Bruckmann, Matthias Munz, Barbara Noack, Esra Guzeldemir-Akcakanat, Jeanette Erdmann, Ingmar Staufenbiel, Lisette C. P. G. M. de Groot, Yvonne Jockel-Schneider, Stefan Schreiber, Nathalie van der Velde, Arne S. Schaefer, Per Hoffmann, Wolfgang Lieb, Andre Franke, Thomas D. Kocher, Bruno G. Loos, Alexander Teumer, J. rgen Wellmann, Matthias Laudes, J. rg Meyle, Rahime M. Nohutcu, Christof Doerfer, Haner Direskeneli, Gesa M. Richter, Christian Graetz, Huseyin Gencay Keceli, André G. Uitterlinden

Publikováno v: Human Molecular Genetics, 26(13), 2577-2588. Oxford University Press
Human molecular genetics, 26(13), 2577-2588. Oxford University Press
Human Molecular Genetics, 26(13), 2577-2588
Munz, M, Willenborg, C, Richter, G M, Jockel-Schneider, Y, Graetz, C, Staufenbiel, I, Wellmann, J, Berger, K, Krone, B, Hoffmann, P, van der Velde, N, Uitterlinden, A G, de Groot, L C P G M, Sawalha, A H, Direskeneli, H, Saruhan-Direskeneli, G, Guzeldemir-Akcakanat, E, Keceli, H G, Laudes, M, Noack, B, Teumer, A, Holtfreter, B, Kocher, T, Eickholz, P, Meyle, J, Doerfer, C, Bruckmann, C, Lieb, W, Franke, A, Schreiber, S, Nohutcu, R M, Erdmann, J, Loos, B G, Jepsen, S, Dommisch, H & Schaefer, A S 2017, ' A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis ', Human molecular genetics, vol. 26, no. 13, pp. 2577-2588 . https://doi.org/10.1093/hmg/ddx151
Human Molecular Genetics 26 (2017) 13

Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. The disease is characterized by destruction of the alveolar bone due to an aberrant host infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4955cac3ff7af2f3140ea0a99e230e
https://pure.eur.nl/en/publications/a5b99f31-febb-44b7-810e-0d53ff03b827