Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Bastian Krenz"'
Publikováno v:
Molecular Oncology, Vol 18, Iss 10, Pp 2338-2355 (2024)
MYC has been implicated in the pathogenesis of a wide range of human tumors and has been described for many years as a transcription factor that regulates genes with pleiotropic functions to promote tumorigenic growth. However, despite extensive effo
Externí odkaz:
https://doaj.org/article/0db5518ccb4c4c76ba0a8d56e3244828
Autor:
Abdallah Gaballa, Anneli Gebhardt-Wolf, Bastian Krenz, Greta Mattavelli, Mara John, Giacomo Cossa, Silvia Andreani, Christina Schülein-Völk, Francisco Montesinos, Raphael Vidal, Carolin Kastner, Carsten P. Ade, Burkhard Kneitz, Georg Gasteiger, Peter Gallant, Mathias Rosenfeldt, Angela Riedel, Martin Eilers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase progression and escape from immune surveillance. Here we show that MYC in PDAC cells is needed for the recruitment of the PAF1c transcription elongation compl
Externí odkaz:
https://doaj.org/article/8a9d10af203b42eb8a6cbb3a3a12d74d
Autor:
Agnes Banaszek, Thomas G. P. Bumm, Boris Nowotny, Maria Geis, Kim Jacob, Matthias Wölfl, Johannes Trebing, Kirstin Kucka, Dina Kouhestani, Tea Gogishvili, Bastian Krenz, Justina Lutz, Leo Rasche, Dirk Hönemann, Hannes Neuweiler, Julia C. Heiby, Ralf C. Bargou, Harald Wajant, Hermann Einsele, Gert Riethmüller, Gernot Stuhler
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The restriction of appropriate tumour-specific antigens is a current limitation for T cell-engaging immunotherapy. Here, the authors have designed a new system constituted by two halve antibodies, which engage T cells once binding to two different an
Externí odkaz:
https://doaj.org/article/2c0baf0c95d243a58f06fcb336d652c2
Autor:
Carina R. Maier, Oliver Hartmann, Cristian Prieto-Garcia, Kamal M. Al-Shami, Lisa Schlicker, Felix C. E. Vogel, Silke Haid, Kevin Klann, Viktoria Buck, Christian Münch, Werner Schmitz, Elias Einig, Bastian Krenz, Marco A. Calzado, Martin Eilers, Nikita Popov, Mathias T. Rosenfeldt, Markus E. Diefenbacher, Almut Schulze
Publikováno v:
Cell Death & Differentiation.
SREBP2 is a master regulator of the mevalonate pathway (MVP), a biosynthetic process that drives the synthesis of dolichol, heme A, ubiquinone and cholesterol and also provides substrates for protein prenylation. Here, we identify SREBP2 as a novel s
Autor:
Martin Eilers, Elmar Wolf, Lars Zender, Stefan Bauer, Mathias T. Rosenfeldt, Georg Gasteiger, Armin Wiegering, Luana D'Artista, Peter Gallant, Ursula Eilers, Apoorva Baluapuri, Emilia Vendelova, Florian Roehrig, Abdallah Gaballa, Carsten P. Ade, Anneli Gebhardt-Wolf, Bastian Krenz
Characterization of MYC function in KPC cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b199ddcbd591f94fbbc25de2c849550c
https://doi.org/10.1158/0008-5472.22429840.v1
https://doi.org/10.1158/0008-5472.22429840.v1
Autor:
Martin Eilers, Elmar Wolf, Lars Zender, Stefan Bauer, Mathias T. Rosenfeldt, Georg Gasteiger, Armin Wiegering, Luana D'Artista, Peter Gallant, Ursula Eilers, Apoorva Baluapuri, Emilia Vendelova, Florian Roehrig, Abdallah Gaballa, Carsten P. Ade, Anneli Gebhardt-Wolf, Bastian Krenz
Deregulated expression of the MYC oncoprotein enables tumor cells to evade immune surveillance, but the mechanisms underlying this surveillance are poorly understood. We show here that endogenous MYC protects pancreatic ductal adenocarcinoma (PDAC) d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265d3c6b93646628a749435b5da04fef
https://doi.org/10.1158/0008-5472.c.6513463.v1
https://doi.org/10.1158/0008-5472.c.6513463.v1
Autor:
Ralf C. Bargou, Gert Riethmüller, Kim Jacob, Matthias Wölfl, Thomas Bumm, Gernot Stuhler, Hermann Einsele, Maria Geis, Dina Kouhestani, Julia C. Heiby, Leo Rasche, Johannes Trebing, Tea Gogishvili, Boris Nowotny, Justina Lutz, Harald Wajant, Dirk Hönemann, Bastian Krenz, Hannes Neuweiler, Kirstin Kucka, Agnes Banaszek
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
T cell-engaging immunotherapies are changing the landscape of current cancer care. However, suitable target antigens are scarce, restricting these strategies to very few tumor types. Here, we report on a T cell-engaging antibody derivative that comes
Autor:
Lars Zender, Carsten P. Ade, Mathias T. Rosenfeldt, Emilia Vendelova, Ursula Eilers, Bastian Krenz, Elmar Wolf, Anneli Gebhardt-Wolf, Armin Wiegering, Peter Gallant, Abdallah Gaballa, Apoorva Baluapuri, Stefan Bauer, Florian Roehrig, Luana D’Artista, Georg Gasteiger, Martin Eilers
Publikováno v:
Cancer Res
Cancer Research
Cancer Research
Deregulated expression of the MYC oncoprotein enables tumor cells to evade immune surveillance, but the mechanisms underlying this surveillance are poorly understood. We show here that endogenous MYC protects pancreatic ductal adenocarcinoma (PDAC) d
Autor:
Elisa Espinet, Karin Feldmann, Jennifer P. Morton, Bastian Krenz, Alexander Kleger, Chiara Falcomatà, Patrick Michl, Pawel K. Mazur, Susanne Sebens, Magdalena Huber, Gwen Lomberk, Martin Eilers, Volker Ellenrieder, Stephan Dreyer, Dieter Saur, Jens T. Siveke, Roland M. Schmid, Thomas M. Gress, Shiv K. Singh, Marina Pasca di Magliano, Nelson Dusetti, Günter Schneider, Channing J. Der, Felix Picard, Feda H. Hamdan, Elisabeth Hessmann, Andreas Trumpp, Steven A. Johnsen, Maximilian Reichert, Anneli Gebhardt, Corinne Bousquet
Pancreatic ductal adenocarcinoma remains a major challenge in cancer medicine. Given the increase in incidence and mortality, interdisciplinary research is necessary to translate basic knowledge into therapeutic strategies improving the outcome of pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f65e2e8a8aa088ae3359304b1e6264d
https://mediatum.ub.tum.de/1640029
https://mediatum.ub.tum.de/1640029