Výsledky vyhledávání - "Bastian, Hatesuer"

Akademický článek

The interferon-induced gene Ifi27l2a is active in lung macrophages and lymphocytes after influenza A infection but deletion of Ifi27l2a in mice does not increase susceptibility to infection.

Autor: Mohamed A Tantawy, Bastian Hatesuer, Esther Wilk, Leonie Dengler, Nadine Kasnitz, Siegfried Weiß, Klaus Schughart

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e106392 (2014)

Interferons represent one of the first and essential host defense mechanisms after infection, and the activation of the IFN-pathway results in the transcriptional activation of hundreds of interferon-stimulated genes. The alpha-inducible protein 27 l

Externí odkaz: https://doaj.org/article/e82577acdfd3487f9251c94227760d76

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Akademický článek

Cellular changes in blood indicate severe respiratory disease during influenza infections in mice.

Autor: Leonie Dengler, Nora Kühn, Dai-Lun Shin, Bastian Hatesuer, Klaus Schughart, Esther Wilk

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e103149 (2014)

Influenza A infection is a serious threat to human and animal health. Many of the biological mechanisms of the host-pathogen-interactions are still not well understood and reliable biomarkers indicating the course of the disease are missing. The mous

Externí odkaz: https://doaj.org/article/fd3f689c2f0344a7848c160b108aba7b

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Akademický článek

Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice.

Autor: Bastian Hatesuer, Stephanie Bertram, Nora Mehnert, Mahmoud M Bahgat, Peter S Nelson, Stefan Pöhlmann, Klaus Schughart

Publikováno v: PLoS Pathogens, Vol 9, Iss 12, p e1003774 (2013)

Annual influenza epidemics and occasional pandemics pose a severe threat to human health. Host cell factors required for viral spread but not for cellular survival are attractive targets for novel approaches to antiviral intervention. The cleavage ac

Externí odkaz: https://doaj.org/article/7cdc567aa0b24c34ae5832e23347ce0d

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Endosomal toll-like receptors 7 and 9 cooperate in detection of murine gammaherpesvirus 68 infection

Autor: Sripriya Murthy, Britt A. Glaunsinger, Melanie M. Brinkmann, Heiko Adler, Baca Chan, Kendra A. Bussey, Bastian Hatesuer, Klaus Schughart, Elisa Reimer

Publikováno v: J. Virol. 93, e01173-18 (2019)
Journal of virology, vol 93, iss 3
Bussey, Kendra A; Murthy, Sripriya; Reimer, Elisa; Chan, Baca; Hatesuer, Bastian; Schughart, Klaus; et al.(2019). Endosomal Toll-Like Receptors 7 and 9 Cooperate in Detection of Murine Gammaherpesvirus 68 Infection.. Journal of virology, 93(3). doi: 10.1128/jvi.01173-18. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/8f5883m0

Murine gammaherpesvirus 68 (MHV68) is a small-animal model suitable for study of the human pathogens Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus. Here, we have characterized the roles of the endosomal Toll-like receptor (TLR) esc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90d6f74839402a2ceaaf5f138ccc02b
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=54752

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Deletion of Irf3 and Irf7 Genes in Mice Results in Altered Interferon Pathway Activation and Granulocyte-Dominated Inflammatory Responses to Influenza A Infection

Autor: Stephanie Trittel, Robert Geffers, Ingo Gerhauser, Hang Thi Thu Hoang, Klaus Schughart, Peggy Riese, Bastian Hatesuer, Husni Elbahesh, Esther Wilk

Publikováno v: Journal of Innate Immunity. 9:145-161

The interferon (IFN) pathway plays an essential role in the innate immune response following viral infections and subsequent shaping of adaptive immunity. Infections with influenza A viruses (IAV) activate the IFN pathway after the recognition of pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1eb7467b8d2860e7b9654327567f6faa
https://doi.org/10.1159/000450705

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Segregation of a Spontaneous Klrd1 (CD94) Mutation in DBA/2 Mouse Substrains

Autor: Ashutosh K. Pandey, Klaus Schughart, Megan K. Mulligan, Robert Geffers, Dai Lun Shin, Esther Wilk, Jesse D. Ziebarth, Robert W. Williams, Bastian Hatesuer

Publikováno v: G3: Genes|Genomes|Genetics

Current model DBA/2J (D2J) mice lack CD94 expression due to a deletion spanning the last coding exon of the Klrd1 gene that occurred in the mid- to late 1980s. In contrast, DBA/2JRj (D2Rj) mice, crosses derived from DBA/2J before 1984, and C57BL/6J (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38af29467cf98f6b14dfc71e5983c76
http://europepmc.org/articles/PMC4321031

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Deletion of Irf3 and Irf7 Genes in Mice Results in Altered Interferon Pathway Activation and Granulocyte-Dominated Inflammatory Responses to Influenza A Infection

Autor: Bastian, Hatesuer, Hang Thi Thu, Hoang, Peggy, Riese, Stephanie, Trittel, Ingo, Gerhauser, Husni, Elbahesh, Robert, Geffers, Esther, Wilk, Klaus, Schughart

Publikováno v: Journal of innate immunity. 9(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f15b14fe2ed0ed9a08168ef05f26fc0e
https://pubmed.ncbi.nlm.nih.gov/27811478

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The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases

Autor: Nora Kühn, Nadine Kösterke, Stefan Pöhlmann, Edith Hummler, Silke Bergmann, Anna Keppner, Siegfried Weiß, Ruth L. O. Lambertz, Judith M. A. van den Brand, Bastian Hatesuer, Klaus Schughart

Publikováno v: Journal of Virology, 90(9), 4298-4307. American Society for Microbiology
Journal of Virology, vol. 90, no. 9, pp. 4298-4307
Journal of Virology

Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is necessary for viral activation and infectivity. In humans and mice, members of the type II transmembrane protease family (TTSP), e.g., TMPRSS2, TMPRSS4, and TMPRSS11d (HAT), hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72d355cb06ecd632206fb18ca74c31e
https://pure.eur.nl/en/publications/82ab0297-cd60-4eba-8f36-47c11536da2b

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Lst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice

Autor: Sarah R. Leist, Heike Kollmus, Bastian Hatesuer, Ruth L. O. Lambertz, Klaus Schughart

Publikováno v: Virology Journal

Background Previously, we performed a quantitative trait locus (QTL) mapping study in BXD recombinant inbred mice to identify host genetic factors that confer resistance to influenza A virus infection. We found Lst1 (leukocyte specific transcript 1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dfcc7d6e288e667045950c406ecce6f
https://pubmed.ncbi.nlm.nih.gov/26817701

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RNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection

Autor: Matthias Preusse, Claudia Pommerenke, Esther Wilk, Bastian Hatesuer, Junxi Wang, Ashutosh K. Pandey, Sarah R. Leist, Klaus Schughart

Publikováno v: BMC Genomics

Background The host response to influenza A infections is strongly influenced by host genetic factors. Animal models of genetically diverse mouse strains are well suited to identify host genes involved in severe pathology, viral replication and immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf21bd4e5c84f40bd836857f9072186
https://doi.org/10.1186/s12864-015-1867-8

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