Genetic polymorphism in Methylenetetrahydrofolate Reductase chloride transport protein 6 (MTHFR CLCN6) gene is associated with keratinocyte skin cancer in a cohort of renal transplant recipients

Autor: Griffin, L, Ho, L, Akhurst, RJ, Arron, ST, Boggs, JME, Conlon, P, O'Kelly, P, Toland, AE, Epstein, EH, Balmain, A, Bastian, BC, Moloney, FJ, Murphy, GM, Laing, ME

Publikováno v: Skin health and disease, vol 2, iss 2

BackgroundRenal transplant recipients (RTRs) are at increased risk of keratinocyte cancer (KC), especially cutaneous squamous cell carcinoma (cSCC). Previous studies identified a genetic variant of the Methylenetetrahydrofolate Reductase (MTHFR) gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::598e5ce946c1b01f1d20790fdaf2026e
https://escholarship.org/uc/item/43c8z3rt

Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma

Autor: Bastian, Boris, Simpson, RM, Bastian, BC, Michael, HT, Webster, JD, Prasad, ML, Conway, CM, Prieto, VM, Gary, JM, Goldschmidt, MH, Esplin, DG

Publikováno v: Bastian, Boris; Simpson, RM; Bastian, BC; Michael, HT; Webster, JD; Prasad, ML; et al.(2014). Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/15c5j6tx

Melanoma represents a significant malignancy in humans and dogs. Different from genetically engineered models, sporadic canine melanocytic neoplasms share several characteristics with human disease that could make dogs a more relevant preclinical mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::b7946d59bd04425315ff36e9f02fd66b
http://www.escholarship.org/uc/item/15c5j6tx

p16(INK4a) expression and cooperates with N-Ras in melanoma development

Autor: Delmas, V, Beermann, F, Martinozzi, S, Carreira, S, Ackermann, J, Kumasaka, M, Denat, L, Goodall, J, Luciani, F, Viros, A, Demirkan, N, Bastian, BC, Goding, CR, Larue, L

Tumor progression is a multistep process in which proproliferation mutations must be accompanied by suppression of senescence. In melanoma, proproliferative signals are provided by activating mutations in NRAS and BRAF, whereas senescence is bypassed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3566::5d6a88b183dbbc18486c26c0d686d229
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/12198

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