Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Bastiaan W. Haak"'
Autor:
Alex R. Schuurman, Joe M. Butler, Erik H.A. Michels, Natasja A. Otto, Xanthe Brands, Bastiaan W. Haak, Fabrice Uhel, Augustijn M. Klarenbeek, Daniël R. Faber, Bauke V. Schomakers, Michel van Weeghel, Alex F. de Vos, Brendon P. Scicluna, Riekelt H. Houtkooper, W. Joost Wiersinga, Tom van der Poll
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107181- (2023)
Summary: Neutrophils are potent immune cells with key antimicrobial functions. Previous in vitro work has shown that neutrophil effector functions are mainly fueled by intracellular glycolysis. Little is known about the state of neutrophils still in
Externí odkaz:
https://doaj.org/article/4e949718e4164c9fb99adf50b5dffd0d
Autor:
Xanthe Brands, Bastiaan W. Haak, Augustijn M. Klarenbeek, Joe Butler, Fabrice Uhel, Wanhai Qin, Natasja A. Otto, Marja E. Jakobs, Daniël R. Faber, René Lutter, W. Joost Wiersinga, Tom van der Poll, Brendon P. Scicluna
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Background The plasticity of monocytes enables them to exert multiple roles during an immune response, including promoting immune tolerance. How monocytes alter their functions to convey immune tolerance in the context of lower respiratory t
Externí odkaz:
https://doaj.org/article/b06b9c428497488dbd62d7b688aaab55
Autor:
Robert F.J. Kullberg, Xanthe Brands, Augustijn M. Klarenbeek, Joe M. Butler, Natasja A. Otto, Daniël R. Faber, Brendon P. Scicluna, Tom van der Poll, W. Joost Wiersinga, Bastiaan W. Haak
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104740- (2022)
Summary: Human studies describing the immunomodulatory role of the intestinal microbiota in systemic infections are lacking. Here, we sought to relate microbiota profiles from 115 patients with community-acquired pneumonia (CAP), both on hospital adm
Externí odkaz:
https://doaj.org/article/66433c03a1ff48519f96542990b54e96
Autor:
Alex R. Schuurman, Tom D.Y. Reijnders, Tjitske S.R. van Engelen, Valentine Léopold, Justin de Brabander, Christine van Linge, Michiel Schinkel, Liza Pereverzeva, Bastiaan W. Haak, Xanthe Brands, Maadrika M.N.P. Kanglie, Inge A.H. van den Berk, Renée A. Douma, Daniël R. Faber, Prabath W.B. Nanayakkara, Jaap Stoker, Jan M. Prins, Brendon P. Scicluna, W. Joost Wiersinga, Tom van der Poll
Publikováno v:
EBioMedicine, Vol 81, Iss , Pp 104082- (2022)
Summary: Background: Community-acquired pneumonia (CAP) can be caused by a variety of pathogens, of which Streptococcus pneumoniae, Influenza and currently SARS-CoV-2 are the most common. We sought to identify shared and pathogen-specific host respon
Externí odkaz:
https://doaj.org/article/85d23ff382c448b9ae4d9aa108476b90
Autor:
Nora S. Wolff, Max C. Jacobs, Bastiaan W. Haak, Joris J. T. H. Roelofs, Alex F. de Vos, Floor Hugenholtz, W. Joost Wiersinga
Publikováno v:
Intensive Care Medicine Experimental, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Background The microbiome has emerged as an important player in the pathophysiology of a whole spectrum of diseases that affect the critically ill. We hypothesized that differences in microbiota composition across vendors can influence murin
Externí odkaz:
https://doaj.org/article/4906848066dc46c8b52c9f3385a077d2
Autor:
Hina N. Khan, Xanthe Brands, Simona Aufiero, Arie J. Hoogendijk, Augustijn M. Klarenbeek, Tjitske S. R. van Engelen, Bastiaan W. Haak, Lonneke A. van Vught, Janneke Horn, Marcus J. Schultz, Aeilko H. Zwinderman, Tom van der Poll, Brendon P. Scicluna
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-12 (2020)
Abstract Background Dysregulation of the host immune response is a pathognomonic feature of sepsis. Abnormal physiological conditions are understood to shift efficient linear splicing of protein-coding RNA towards non-canonical splicing, characterize
Externí odkaz:
https://doaj.org/article/513972d7beef4ee78770d62e5c16ca46
Autor:
Robert F.J. Kullberg, Floor Hugenholtz, Xanthe Brands, Cormac M. Kinsella, Hessel Peters-Sengers, Joe M. Butler, Martin Deijs, Michelle Klein, Daniël R. Faber, Brendon P. Scicluna, Tom Van der Poll, Lia Van der Hoek, W. Joost Wiersinga, Bastiaan W. Haak
Publikováno v:
EClinicalMedicine, Vol 39, Iss , Pp 101074- (2021)
Background Bacterial intestinal communities interact with the immune system and may contribute to protection against community-acquired pneumonia (CAP). Intestinal viruses are closely integrated with these bacterial communities, yet the composition a
Externí odkaz:
https://doaj.org/article/ec161f875f9c4b53ac8f3fe2ed658422
Autor:
Bastiaan W. Haak, Ricard Argelaguet, Cormac M. Kinsella, Robert F. J. Kullberg, Jacqueline M. Lankelma, Martin Deijs, Michelle Klein, Maarten F. Jebbink, Floor Hugenholtz, Sarantos Kostidis, Martin Giera, Theodorus B. M. Hakvoort, Wouter J. de Jonge, Marcus J. Schultz, Tom van Gool, Tom van der Poll, Willem M. de Vos, Lia M. van der Hoek, W. Joost Wiersinga
Publikováno v:
mSystems, Vol 6, Iss 2 (2021)
ABSTRACT Bacterial microbiota play a critical role in mediating local and systemic immunity, and shifts in these microbial communities have been linked to impaired outcomes in critical illness. Emerging data indicate that other intestinal organisms,
Externí odkaz:
https://doaj.org/article/e461e2bc3b1c4a9998ab70e0d1a95315
Autor:
Robert F. J. Kullberg, Bastiaan W. Haak, Mahmoud I. Abdel-Aziz, Mark Davids, Floor Hugenholtz, Max Nieuwdorp, Henrike Galenkamp, Maria Prins, Anke H. Maitland-van der Zee, W. Joost Wiersinga
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
Bacterial gut communities might predispose children to develop asthma. Yet, little is known about the role of these micro-organisms in adult asthmatics. We aimed to profile the relationship between fecal microbiota and asthma in a large-scale, ethnic
Externí odkaz:
https://doaj.org/article/4f24724ebb144da699044e2232943a6e
Autor:
Xanthe Brands, Bastiaan W. Haak, Augustijn M. Klarenbeek, Natasja A. Otto, Daniël R. Faber, René Lutter, Brendon P. Scicluna, W. Joost Wiersinga, Tom van der Poll
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/be43d72b84be4a4796a245a1618bff3d