Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Bastiaan Van der Roest"'
Autor:
Freek Manders, Arianne M. Brandsma, Jurrian de Kanter, Mark Verheul, Rurika Oka, Markus J. van Roosmalen, Bastiaan van der Roest, Arne van Hoeck, Edwin Cuppen, Ruben van Boxtel
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Background The collective of somatic mutations in a genome represents a record of mutational processes that have been operative in a cell. These processes can be investigated by extracting relevant mutational patterns from sequencing data. R
Externí odkaz:
https://doaj.org/article/2850a20877ff45f2957546fea6286f10
Autor:
Luan Nguyen, Myrthe Jager, Ruby Lieshout, Petra E. de Ruiter, Mauro D. Locati, Nicolle Besselink, Bastiaan van der Roest, Roel Janssen, Sander Boymans, Jeroen de Jonge, Jan N. M. IJzermans, Michail Doukas, Monique M. A. Verstegen, Ruben van Boxtel, Luc J. W. van der Laan, Edwin Cuppen, Ewart Kuijk
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Nguyen et al. used liver organoid cultures to identify all somatic mutations in individual stem cells from patients with common liver diseases that confer risk of cancer. The authors report that, compared to healthy liver, these precancerous liver di
Externí odkaz:
https://doaj.org/article/96839cce3bec43feb376e5547a803268
Autor:
Ewart Kuijk, Myrthe Jager, Bastiaan van der Roest, Mauro D. Locati, Arne Van Hoeck, Jerome Korzelius, Roel Janssen, Nicolle Besselink, Sander Boymans, Ruben van Boxtel, Edwin Cuppen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Genetic changes acquired during in vitro culture pose a challenge to application of stem cells. Here the authors use whole genome sequencing to show that cultured human adult and pluripotent stem cells have a high mutational load caused by oxidative
Externí odkaz:
https://doaj.org/article/1f6a475491464666a79c0e3f7512c41e
Autor:
Sharon Christensen, Bastiaan Van der Roest, Nicolle Besselink, Roel Janssen, Sander Boymans, John W. M. Martens, Marie-Laure Yaspo, Peter Priestley, Ewart Kuijk, Edwin Cuppen, Arne Van Hoeck
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
5-Fluorouracil (5-FU) is a commonly used chemo drug to treat cancer patients. Using in vitro 5-FU treated organoids and in vivo 5-FU treated human cancer data, the authors describe a 5-FU mutational signature that is similar to COSMIC signature 17 fr
Externí odkaz:
https://doaj.org/article/367df1c239a3400ab814acaa85f4ccbc
Autor:
Ewart Kuijk, Myrthe Jager, Bastiaan van der Roest, Mauro D. Locati, Arne Van Hoeck, Jerome Korzelius, Roel Janssen, Nicolle Besselink, Sander Boymans, Ruben van Boxtel, Edwin Cuppen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/ed8e577e7e504584b8fd4c8ae2098f00
Autor:
Ruben van Boxtel, Nicolle Besselink, Mauro D. Locati, Sander Boymans, Ruby Lieshout, Roel Janssen, Luan Nguyen, Michail Doukas, Myrthe Jager, Ewart W. Kuijk, Edwin Cuppen, Luc J. W. van der Laan, Jeroen de Jonge, Bastiaan van der Roest, Jan N. M. IJzermans, Petra E. de Ruiter, Monique M A Verstegen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Communications Biology, 4(1):1301. Springer Nature
Communications Biology
Communications Biology, 4(1):1301. Springer Nature
Communications Biology
Inflammatory liver disease increases the risk of developing primary liver cancer. The mechanism through which liver disease induces tumorigenesis remains unclear, but is thought to occur via increased mutagenesis. Here, we performed whole-genome sequ
Autor:
Sippe G. de Vries, Wigard P. Kloosterman, Holger Rehmann, William Cross, Myrna van den Bos, Sander Boymans, Bingxin Lu, Susanne M.A. Lens, Hugo J. Snippert, Yannik Bollen, Markus J. van Roosmalen, Maximilian Mossner, Nicolle Besselink, Ellen Stelloo, Christopher Kimberley, Edwin Cuppen, Chris P. Barnes, Petra van Leenen, Bas Ponsioen, Ana C. F. Bolhaqueiro, Koen C. Oost, Bastiaan van der Roest, Trevor A. Graham, Andrea Sottoriva, Geert J. P. L. Kops, Leon W.M.M. Terstappen
Publikováno v:
Nature Genetics, 53(8), 1187-1195. Nature Publishing Group
Nature Genetics
Nature genetics, 53(8), 1187-1195. Nature Publishing Group
Nature Genetics
Nature genetics, 53(8), 1187-1195. Nature Publishing Group
Central to tumor evolution is the generation of genetic diversity. However, the extent and patterns by which de novo karyotype alterations emerge and propagate within human tumors are not well understood, especially at single-cell resolution. Here, w
Autor:
Freek Manders, Arianne M. Brandsma, Jurrian de Kanter, Mark Verheul, Rurika Oka, Markus J. van Roosmalen, Bastiaan van der Roest, Arne van Hoeck, Edwin Cuppen, Ruben van Boxtel
Publikováno v:
BMC genomics. 23(1)
Background The collective of somatic mutations in a genome represents a record of mutational processes that have been operative in a cell. These processes can be investigated by extracting relevant mutational patterns from sequencing data. Results He
Autor:
Arne Van Hoeck, Ewart W. Kuijk, Bastiaan van der Roest, Sharon Christensen, Edwin Cuppen, John W.M. Martens, Peter Priestley, Sander Boymans, Marie-Laure Yaspo, Roel Janssen, Nicolle Besselink
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications, 10(1). Nature Publishing Group
Nature Communications, 10:4571. Nature Publishing Group
Nature Communications
Nature Communications, 10(1). Nature Publishing Group
Nature Communications, 10:4571. Nature Publishing Group
5-Fluorouracil (5-FU) is a chemotherapeutic drug commonly used for the treatment of solid cancers. It is proposed that 5-FU interferes with nucleotide synthesis and incorporates into DNA, which may have a mutational impact on both surviving tumor and
Autor:
Arne Van Hoeck, Ruben van Boxtel, Sander Boymans, Roel Janssen, Mauro D. Locati, Jerome Korzelius, Edwin Cuppen, Nicolle Besselink, Myrthe Jager, Ewart W. Kuijk, Bastiaan van der Roest
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Genetic changes acquired during in vitro culture pose a risk for the successful application of stem cells in regenerative medicine. To assess the genetic risks induced by culturing, we determined all mutations in individual human stem cells by whole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f115a6e2847bdbd69309515e0713bfa
https://kar.kent.ac.uk/81480/1/s41467-020-16323-4.pdf
https://kar.kent.ac.uk/81480/1/s41467-020-16323-4.pdf