Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Bastiaan T Heijmans"'
Autor:
Pooja R Mandaviya, Roby Joehanes, Dylan Aïssi, Brigitte Kühnel, Riccardo E Marioni, Vinh Truong, Lisette Stolk, Marian Beekman, Marc Jan Bonder, Lude Franke, Christian Gieger, Tianxiao Huan, M Arfan Ikram, Sonja Kunze, Liming Liang, Jan Lindemans, Chunyu Liu, Allan F McRae, Michael M Mendelson, Martina Müller-Nurasyid, Annette Peters, P Eline Slagboom, John M Starr, David-Alexandre Trégouët, André G Uitterlinden, Marleen M J van Greevenbroek, Diana van Heemst, Maarten van Iterson, Philip S Wells, Chen Yao, Ian J Deary, France Gagnon, Bastiaan T Heijmans, Daniel Levy, Pierre-Emmanuel Morange, Melanie Waldenberger, Sandra G Heil, Joyce B J van Meurs, CHARGE Consortium Epigenetics group and BIOS Consortium
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0182472 (2017)
BACKGROUND:DNA methylation is affected by the activities of the key enzymes and intermediate metabolites of the one-carbon pathway, one of which involves homocysteine. We investigated the effect of the well-known genetic variant associated with mildl
Externí odkaz:
https://doaj.org/article/a894904b6bef47d19d0b9de51287e06e
Autor:
M. Jazmin Taeubert, Thomas B. Kuipers, Jiayi Zhou, Chihua Li, Shuang Wang, Tian Wang, Elmar W. Tobi, BBMRI-NL Metabolomics consortium, Daniel W. Belsky, L. H. Lumey, Bastiaan T. Heijmans
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-10 (2024)
Abstract Background Exposure to famine in the prenatal period is associated with an increased risk of metabolic disease, including obesity and type 2 diabetes. We employed nuclear magnetic resonance (NMR) metabolomic profiling to identify the metabol
Externí odkaz:
https://doaj.org/article/115855a307414678ac53b013ac2278ed
Autor:
Roderick C Slieker, Matthias S Roost, Liesbeth van Iperen, H Eka D Suchiman, Elmar W Tobi, Françoise Carlotti, Eelco J P de Koning, P Eline Slagboom, Bastiaan T Heijmans, Susana M Chuva de Sousa Lopes
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005583 (2015)
Remodelling the methylome is a hallmark of mammalian development and cell differentiation. However, current knowledge of DNA methylation dynamics in human tissue specification and organ development largely stems from the extrapolation of studies in v
Externí odkaz:
https://doaj.org/article/6eff305b4df44ec0bed77e984e8fe9c6
Autor:
H. Eka D. Suchiman, Roderick C. Slieker, Dennis eKremer, P. Eline eSlagboom, Bastiaan T Heijmans, Elmar Wouter Tobi
Publikováno v:
Frontiers in Genetics, Vol 6 (2015)
EpiTYPER® is a mass spectrometry-based bisulfite sequencing method that enables region-specific DNA methylation analysis in a quantitative and high-throughput fashion. The technology targets genomic regions of 100-600 base pairs and results in the q
Externí odkaz:
https://doaj.org/article/e8a2565858eb43c08ba442cd656affb7
Autor:
Julia Lange de Luna, Aayah Nounu, Sonja Neumeyer, Lucy Sinke, Rory Wilson, Fabian Hellbach, Pamela R. Matías-García, Thomas Delerue, Juliane Winkelmann, Annette Peters, Barbara Thorand, Marian Beekman, Bastiaan T. Heijmans, Eline Slagboom, Christian Gieger, Jakob Linseisen, Melanie Waldenberger
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Dietary intake of n-3 polyunsaturated fatty acids (PUFA) may have a protective effect on the development of cardiovascular diseases, diabetes, depression and cancer, while a high intake of n-6 PUFA was often reported to be associa
Externí odkaz:
https://doaj.org/article/0c2d8b5f2bb94eac9bcb5c4861efb66f
Autor:
Jeffrey J W Verschuren, Stella Trompet, M Lourdes Sampietro, Bastiaan T Heijmans, Werner Koch, Adnan Kastrati, Jeanine J Houwing-Duistermaat, P Eline Slagboom, Paul H A Quax, J Wouter Jukema
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70676 (2013)
BackgroundCoronary restenosis after percutaneous coronary intervention (PCI) still remains a significant limitation of the procedure. The causative mechanisms of restenosis have not yet been fully identified. The goal of the current study was to perf
Externí odkaz:
https://doaj.org/article/e1c0920721814b3087ab0fc56b703b7c
Autor:
Marieke I Bouwland-Both, Nina H van Mil, Lisette Stolk, Paul H C Eilers, Michael M P J Verbiest, Bastiaan T Heijmans, Henning Tiemeier, Albert Hofman, Eric A P Steegers, Vincent W V Jaddoe, Régine P M Steegers-Theunissen
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81731 (2013)
Changes in epigenetic programming of embryonic growth genes during pregnancy seem to affect fetal growth. Therefore, in a population-based prospective birth cohort in the Netherlands, we examined associations between fetal and infant growth and DNA m
Externí odkaz:
https://doaj.org/article/579738e41b814aa4963e6865f864c91b
Autor:
Jeffrey J W Verschuren, Stella Trompet, Joris Deelen, David J Stott, Naveed Sattar, Brendan M Buckley, Ian Ford, Bastiaan T Heijmans, Henk-Jan Guchelaar, Jeanine J Houwing-Duistermaat, P Eline Slagboom, J Wouter Jukema
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56262 (2013)
PURPOSE: DNA repair deficiencies have been postulated to play a role in the development and progression of cardiovascular disease (CVD). The hypothesis is that DNA damage accumulating with age may induce cell death, which promotes formation of unstab
Externí odkaz:
https://doaj.org/article/7782af70a9d547979b7d6c951ec3ce20
Autor:
Yingchang Lu, Anika Vaarhorst, Audrey H H Merry, Martijn E T Dollé, Robert Hovenier, Sandra Imholz, Leo J Schouten, Bastiaan T Heijmans, Michael Müller, P Eline Slagboom, Piet A van den Brandt, Anton P M Gorgels, Jolanda M A Boer, Edith J M Feskens
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41681 (2012)
BackgroundIntakes of n-3 polyunsaturated fatty acids (PUFAs), especially EPA (C20:5n-3) and DHA (C22:6n-3), are known to prevent fatal coronary heart disease (CHD). The effects of n-6 PUFAs including arachidonic acid (C20:4n-6), however, remain uncle
Externí odkaz:
https://doaj.org/article/0b15f566918a445fab69bc7311bd0dac
Autor:
Elmar W Tobi, P Eline Slagboom, Jenny van Dongen, Dennis Kremer, Aryeh D Stein, Hein Putter, Bastiaan T Heijmans, L H Lumey
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37933 (2012)
Both the early environment and genetic variation may affect DNA methylation, which is one of the major molecular marks of the epigenome. The combined effect of these factors on a well-defined locus has not been studied to date. We evaluated the assoc
Externí odkaz:
https://doaj.org/article/1c14f2a61cfc4323996baf9a717d8449