Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Bastiaan Spanjaard"'
Autor:
Marius Lange, Zoe Piran, Michal Klein, Bastiaan Spanjaard, Dominik Klein, Jan Philipp Junker, Fabian J. Theis, Mor Nitzan
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-38 (2024)
Abstract Simultaneous profiling of single-cell gene expression and lineage history holds enormous potential for studying cellular decision-making. Recent computational approaches combine both modalities into cellular trajectories; however, they canno
Externí odkaz:
https://doaj.org/article/f18898a9969744c8a28f8aa670e6fcef
Autor:
Nina Mitic, Anika Neuschulz, Bastiaan Spanjaard, Julia Schneider, Nora Fresmann, Klara Tereza Novoselc, Taraneh Strunk, Lisa Münster, Pedro Olivares-Chauvet, Jovica Ninkovic, Jan Philipp Junker
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 4, Pp 321-337 (2024)
Abstract Adult stem cells are important for tissue turnover and regeneration. However, in most adult systems it remains elusive how stem cells assume different functional states and support spatially patterned tissue architecture. Here, we dissected
Externí odkaz:
https://doaj.org/article/05349cd3ad13492f958e56557b17da7e
Autor:
Karoline Holler, Anika Neuschulz, Philipp Drewe-Boß, Janita Mintcheva, Bastiaan Spanjaard, Roberto Arsiè, Uwe Ohler, Markus Landthaler, Jan Philipp Junker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Early stages of embryogenesis are known to depend on subcellular localization and transport of maternal mRNA, but systematic analyses have been hindered by a lack of methods for tracking of RNA. Here the authors combine spatially-resolved transcripto
Externí odkaz:
https://doaj.org/article/ccde7f9fb6194c37951752ef36e5cf99
Autor:
Bo Hu, Sara Lelek, Bastiaan Spanjaard, Hadil El-Sammak, Mariana Guedes Simões, Janita Mintcheva, Hananeh Aliee, Ronny Schäfer, Alexander M. Meyer, Fabian Theis, Didier Y. R. Stainier, Daniela Panáková, Jan Philipp Junker
Publikováno v:
Nature Genetics
Nat. Genet. 54, 1227-1237 (2022)
Nat. Genet. 54, 1227-1237 (2022)
The adult zebrafish heart has a high capacity for regeneration following injury. However, the composition of the regenerative niche has remained largely elusive. Here, we dissected the diversity of activated cell states in the regenerating zebrafish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e413c6e55759c012d882806d4d4eeb24
https://doi.org/10.1038/s41588-022-01129-5
https://doi.org/10.1038/s41588-022-01129-5
Autor:
Marius Lange, Zoe Piran, Michal Klein, Bastiaan Spanjaard, Dominik Klein, Jan Philipp Junker, Fabian J. Theis, Mor Nitzan
Simultaneous profiling of single-cell gene expression and lineage history holds enormous potential for studying cellular decision-making beyond simpler pseudotime-based approaches. However, it is currently unclear how lineage and gene expression info
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4ff704ad11cf11b879f751475c1999f
https://doi.org/10.1101/2023.04.14.536867
https://doi.org/10.1101/2023.04.14.536867
Autor:
Eugene Berezikov, Hendrik C. Korswagen, Bastiaan Spanjaard, Jan Philipp Junker, Marco C. Betist, Annabel Ebbing, Ábel Vértesy, Alexander van Oudenaarden
Publikováno v:
Developmental Cell, 47(6), 801. Cell Press
Developmental Cell, 47(6), 801-813. CELL PRESS
Developmental Cell, 47(6), 801-813.e6. Cell Press
Developmental Cell, 47(6), 801-813. CELL PRESS
Developmental Cell, 47(6), 801-813.e6. Cell Press
To advance our understanding of the genetic programs that drive cell and tissue specialization, it is necessary to obtain a comprehensive overview of gene expression patterns. Here, we have used spatial transcriptomics to generate high-resolution, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b96684d383025fe98c14f65776e4b7
https://hdl.handle.net/11370/ac004c12-2fc2-47be-8a15-8c38badcb7e2
https://hdl.handle.net/11370/ac004c12-2fc2-47be-8a15-8c38badcb7e2
Autor:
Ronny Schäfer, Jan Philipp Junker, B. Hu, Mariana G. Simões, Daniela Panáková, S. Lelek, Fabian J. Theis, Bastiaan Spanjaard, Hananeh Aliee
Myocardial infarction is a leading cause of death worldwide, as the adult human heart does not have the ability to regenerate efficiently after insults. In contrast, the adult zebrafish heart has a high capacity for regeneration, and understanding th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dd5457afef8181857dab3cbc798e084
https://doi.org/10.1101/2021.01.07.425670
https://doi.org/10.1101/2021.01.07.425670
Autor:
Neuschulz A, Mintcheva J, Uwe Ohler, Bastiaan Spanjaard, Drewe-Boß P, Roberto Arsie, Karoline Holler, Markus Landthaler, Jan Philipp Junker
SummaryEarly stages of embryogenesis depend heavily on subcellular localization and transport of maternally deposited mRNA. However, systematic analysis of these processes is currently hindered by a lack of spatio-temporal information in single-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddc631c93714618b7c0ed0533029c229
https://doi.org/10.1101/2020.11.19.389809
https://doi.org/10.1101/2020.11.19.389809
Autor:
Jan Philipp Junker, Bastiaan Spanjaard
Publikováno v:
Current Opinion in Cell Biology. 49:16-21
Determining the lineage origin of cell types is a major goal in developmental biology. Furthermore, lineage tracing is a powerful approach for understanding the origin of developmental defects as well as the origin of diseases such as cancer. There i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d46e49cfa3ee68e06a84ff9ea1624c
https://doi.org/10.1016/j.ceb.2017.11.004
https://doi.org/10.1016/j.ceb.2017.11.004
Autor:
Charlotte Demkes, Mauro Giacca, Bastiaan Spanjaard, Farhad Akbari Moqadam, Lieneke Kooijman, Hesther de Ruiter, Lorena Zentilin, D Versteeg, Bas Molenaar, Anne Katrine Johansen, Eva van Rooij, Ana Rita Leitoguinho
Publikováno v:
Circulation Research, 121(10), 1168-1181. Lippincott Williams & Wilkins
Rationale: CRISPR/Cas9 (clustered regularly interspaced palindromic repeats/CRISPR-associated protein 9)–based DNA editing has rapidly evolved as an attractive tool to modify the genome. Although CRISPR/Cas9 has been extensively used to manipulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb66c30d26a595eda1fb2d3c95d584e3
https://doi.org/10.1161/circresaha.116.310370
https://doi.org/10.1161/circresaha.116.310370