Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Bassil M. Kublaoui"'
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36453 (2012)
Single-minded 1 (Sim1) is a transcription factor necessary for development of the paraventricular nucleus of the hypothalamus (PVH). This nucleus is a critical regulator of appetite, energy expenditure and body weight. Previously we showed that Sim1(
Externí odkaz:
https://doaj.org/article/66a7640293804114b0face568d06a07a
Publikováno v:
Pediatrics. 124:573-579
OBJECTIVE: To assess available blood tests as potential screening tools for impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). METHODS: We studied 468 obese (BMI mean: 34.4 kg/m2) children, including a subgroup with serum fasting i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9bfc2bc8c98c28ce3e7e495e4fb39c
https://doi.org/10.1542/peds.2008-2949
https://doi.org/10.1542/peds.2008-2949
Publikováno v:
Molecular Endocrinology. 22:1723-1734
Single-minded 1 (Sim1) encodes a transcription factor essential for formation of the hypothalamic paraventricular nucleus (PVN). Sim1 haploinsufficiency is associated with hyperphagic obesity and increased linear growth in humans and mice, similar to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f19895592029a830647a0a0a266e1bc
https://doi.org/10.1210/me.2008-0067
https://doi.org/10.1210/me.2008-0067
Publikováno v:
Endocrinology. 147:4542-4549
Single-minded 1 (SIM1) mutations are associated with obesity in mice and humans. Haploinsufficiency of mouse Sim1 causes hyperphagic obesity with increased linear growth and enhanced sensitivity to a high-fat diet, a phenotype similar to that of agou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78990e0de721e9771c767929f6bf9af8
https://doi.org/10.1210/en.2006-0453
https://doi.org/10.1210/en.2006-0453
Publikováno v:
Molecular Endocrinology. 20:2483-2492
Single-minded 1 (SIM1) is one of only six genes implicated in human monogenic obesity. Haploinsufficiency of this hypothalamic transcription factor is associated with hyperphagic obesity and increased linear growth in both humans and mice. Additional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e092ac8e4340d62ed542b3efc72d0fa
https://doi.org/10.1210/me.2005-0483
https://doi.org/10.1210/me.2005-0483
Autor:
Andrew R. Zinn, Bassil M. Kublaoui
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 91:1671-1672
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02a053a18bd88b64d83ee576dc21105b
https://doi.org/10.1210/jc.2006-0546
https://doi.org/10.1210/jc.2006-0546