Systemic infection in aged mice causes upregulation of crystallin alpha A in the RPE/choroid.

Autor: Lunding BS; Department of Immunology and Microbiology, University of Copenhagen, Denmark., Bassi MR; Department of Immunology and Microbiology, University of Copenhagen, Denmark., Christensen JP; Department of Immunology and Microbiology, University of Copenhagen, Denmark., Thomsen AR; Department of Immunology and Microbiology, University of Copenhagen, Denmark., Sørensen TL; Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark; Faculty of Health Sciences, University of Copenhagen, Denmark., Vorum H; Department of Clinical Medicine, Aalborg University, Denmark; Department of Ophthalmology, Aalborg University Hospital, Denmark., Honoré B; Department of Biomedicine, Aarhus University, Denmark., Nissen MH; Department of Immunology and Microbiology, University of Copenhagen, Denmark., Steffensen MA; Department of Immunology and Microbiology, University of Copenhagen, Denmark. Electronic address: mariaas@sund.ku.dk.

Publikováno v: Experimental eye research [Exp Eye Res] 2024 Aug; Vol. 245, pp. 109984. Date of Electronic Publication: 2024 Jun 28.

Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA.

Autor: Raghavan SSR; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Dagil R; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Lopez-Perez M; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Conrad J; Swedish National Cryo-EM Facility, Science for Life Laboratories, Solna, Sweden., Bassi MR; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Quintana MDP; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Choudhary S; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Gustavsson T; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Wang Y; Joint Research Centre for Engineering Biology, Zhejiang University-University of Edinburgh Institute, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China., Gourdon P; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Experimental Medical Science, Lund University, Lund, Sweden., Ofori MF; Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Christensen SB; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Minja DTR; National Institute for Medical Research, Tanga Centre, Tanga, Tanzania., Schmiegelow C; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Nielsen MA; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Barfod L; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Hviid L; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Salanti A; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Lavstsen T; Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Wang K; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: PLoS pathogens [PLoS Pathog] 2022 Nov 16; Vol. 18 (11), pp. e1010924. Date of Electronic Publication: 2022 Nov 16 (Print Publication: 2022).

Strain-Dependent Inhibition of Erythrocyte Invasion by Monoclonal Antibodies Against Plasmodium falciparum CyRPA.

Autor: Knudsen AS; Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Björnsson KH; Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bassi MR; Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Walker MR; Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kok A; Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Cristinoi B; Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jensen AR; Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Barfod L; Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: Frontiers in immunology [Front Immunol] 2021 Aug 10; Vol. 12, pp. 716305. Date of Electronic Publication: 2021 Aug 10 (Print Publication: 2021).

A Systematic, Unbiased Mapping of CD8 ⁺ and CD4 ⁺ T Cell Epitopes in Yellow Fever Vaccinees.

Autor: Stryhn A; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kongsgaard M; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rasmussen M; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Harndahl MN; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Østerbye T; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bassi MR; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Thybo S; Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark., Gabriel M; Medical Office, Copenhagen, Denmark., Hansen MB; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark., Nielsen M; Department of Health Technology, The Technical University of Denmark, Lyngby, Denmark.; Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín, Buenos Aires, Argentina., Christensen JP; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Randrup Thomsen A; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Buus S; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: Frontiers in immunology [Front Immunol] 2020 Aug 31; Vol. 11, pp. 1836. Date of Electronic Publication: 2020 Aug 31 (Print Publication: 2020).

MHC class II invariant chain-adjuvanted viral vectored vaccines enhances T cell responses in humans.

Autor: Esposito I; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK., Cicconi P; The Jenner Institute Laboratories, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK., D'Alise AM; ReiThera s.r.l., 00128 Rome, Italy., Brown A; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK., Esposito M; ReiThera s.r.l., 00128 Rome, Italy., Swadling L; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK., Holst PJ; Center for Medical Parasitology, University of Copenhagen, DK-2200 Copenhagen, Denmark.; Department of Immunology and Microbiology, University of Copenhagen, DK-2200 Copenhagen, Denmark.; InProTher ApS, BioInnovation Institute, 2200 Copenhagen, Denmark., Bassi MR; Center for Medical Parasitology, University of Copenhagen, DK-2200 Copenhagen, Denmark., Stornaiuolo M; Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy., Mori F; ReiThera s.r.l., 00128 Rome, Italy., Vassilev V; GSK Vaccines, 1330 Rixensart, Belgium., Li W; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK., Donnison T; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK., Gentile C; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy., Turner B; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK., von Delft A; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK., Del Sorbo M; ReiThera s.r.l., 00128 Rome, Italy., Barra F; ReiThera s.r.l., 00128 Rome, Italy., Contino AM; ReiThera s.r.l., 00128 Rome, Italy., Abbate A; ReiThera s.r.l., 00128 Rome, Italy., Novellino E; Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy., Thomsen AR; Department of Immunology and Microbiology, University of Copenhagen, DK-2200 Copenhagen, Denmark., Christensen JP; Department of Immunology and Microbiology, University of Copenhagen, DK-2200 Copenhagen, Denmark., Lahm A; ReiThera s.r.l., 00128 Rome, Italy., Grazioli F; ReiThera s.r.l., 00128 Rome, Italy., Ammendola V; ReiThera s.r.l., 00128 Rome, Italy., Siani L; ReiThera s.r.l., 00128 Rome, Italy., Colloca S; ReiThera s.r.l., 00128 Rome, Italy., Klenerman P; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.; The Jenner Institute Laboratories, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK., Nicosia A; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.; CEINGE-Biotecnologie Avanzate, via Gaetano Salvatore 486, 80145 Naples, Italy.; Keires AG, 4051 Basel, Switzerland., Dorrell L; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.; Oxford NIHR Biomedical Research Centre, Headington OX3 9DU, UK., Folgori A; ReiThera s.r.l., 00128 Rome, Italy., Capone S; ReiThera s.r.l., 00128 Rome, Italy., Barnes E; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK. ellie.barnes@ndm.ox.ac.uk.; The Jenner Institute Laboratories, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.

Publikováno v: Science translational medicine [Sci Transl Med] 2020 Jun 17; Vol. 12 (548).