The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Autor: Capalbo, Luisa, Bassi, Zuni I., Geymonat, Marco, Todesca, Sofia, Copoiu, Liviu, Enright, Anton J., Callaini, Giuliano, Riparbelli, Maria Giovanna, Yu, Lu, Choudhary, Jyoti S., Ferrero, Enrico, Wheatley, Sally, Douglas, Max E., Mishima, Masanori

The midbody is an organelle assembled at the intercellular bridge between the two daughter cells at the end of mitosis. It controls the final separation of the daughter cells and has been involved in cell fate, polarity, tissue organization, and cili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7d028472390f8dd9daa27a47c7194c80
https://nottingham-repository.worktribe.com/file/3017619/1/s41467-019-12507-9

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Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis

Autor: Bassi, Zuni I, Verbrugghe, Koen J, Capalbo, Luisa, Gregory, Stephen, Montembault, Emilie, Glover, David M, D'Avino, Pier Paolo

In many organisms, the small guanosine triphosphatase RhoA controls assembly and contraction of the actomyosin ring during cytokinesis by activating different effectors. Although the role of some RhoA effectors like formins and Rho kinase is reasonab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b46d1ce1cbf62186d3acc8e1b05d5832

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis.

Autor: Capalbo L; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK., Bassi ZI; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK., Geymonat M; Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK., Todesca S; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK., Copoiu L; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.; Department of Biochemistry, University of Cambridge, Cambridge, UK., Enright AJ; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK., Callaini G; Department of Medical Biotechnologies, University of Siena, Via A. Moro 4, 53100, Siena, Italy., Riparbelli MG; Department of Life Sciences, University of Siena, Via A. Moro 4, 53100, Siena, Italy., Yu L; The Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.; The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Choudhary JS; The Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.; The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK., Ferrero E; Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.; Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK.; Autoimmunity, Transplantation and Inflammation Bioninfomatics, Novartis Institutes for BioMedical Research, 4056, Basel, Switzerland., Wheatley S; School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK., Douglas ME; Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, CB2 1QN, UK.; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Mishima M; Wellcome Trust/Cancer Research UK Gurdon Institute, Cambridge, CB2 1QN, UK.; Centre for Mechanochemical Cell Biology and Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK., D'Avino PP; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK. ppd21@cam.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2019 Oct 04; Vol. 10 (1), pp. 4513. Date of Electronic Publication: 2019 Oct 04.