Genomic reconstruction of the SARS-CoV-2 epidemic in England

Autor: Vöhringer, HS, Sanderson, T, Sinnott, M, De Maio, N, Nguyen, T, Goater, R, Schwach, F, Harrison, I, Hellewell, J, Ariani, CV, Gonçalves, S, Jackson, DK, Johnston, I, Jung, AW, Saint, C, Sillitoe, J, Suciu, M, Goldman, N, Panovska-Griffiths, J, Abnizova, I, Aigrain, L, Alderton, A, Ali, M, Allen, L, Amato, R, Anderson, R, Ariani, C, Austin-Guest, S, Bala, S, Barrett, J, Bassett, A, Battleday, K, Beal, J, Beale, M, Beaver, C, Bellany, S, Bellerby, T, Bellis, K, Berger, D, Berriman, M, Betteridge, E, Bevan, P, Binley, S, Bishop, J, Blackburn, K, Bonfield, J, Boughton, N, Bowker, S, Brendler-Spaeth, T, Bronner, I, Brooklyn, T, Buddenborg, SK, Bush, R, Caetano, C, Cagan, A, Carter, N, Cartwright, J, Monteiro, TC, Chapman, L, Chillingworth, T-J, Clapham, P, Clark, R, Clarke, A, Clarke, C, Cole, D, Cook, E, Coppola, M, Cornell, L, Cornwell, C, Corton, C, Crackett, A, Cranage, A, Craven, H, Craw, S, Crawford, M, Cutts, T, Dabrowska, M, Davies, M, Davies, R, Dawson, J, Day, C, Densem, A, Dibling, T, Dockree, C, Dodd, D, Dogga, S, Dorman, M, Dougan, G, Dougherty, M, Dove, A, Drummond, L, Drury, E, Dudek, M, Durham, J, Durrant, L, Easthope, E, Eckert, S, Ellis, P, Farr, B, Fenton, M, Ferrero, M, Flack, N, Fordham, H, Forsythe, G, Foulser, L, Francis, M, Fraser, A, Freeman, A, Galvin, A, Garcia-Casado, M, Gedny, A, Girgis, S, Glover, J, Goncalves, S, Goodwin, S, Gould, O, Gourtovaia, M, Gray, A, Gray, E, Griffiths, C, Gu, Y, Guerin, F, Hamilton, W, Hanks, H, Harrison, E, Harrott, A, Harry, E, Harvison, J, Heath, P, Hernandez-Koutoucheva, A, Hobbs, R, Holland, D, Holmes, S, Hornett, G, Hough, N, Huckle, L, Hughes-Hallet, L, Hunter, A, Inglis, S, Iqbal, S, Jackson, A, Jackson, D, James, K, Jamrozy, D, Verdejo, CJ, Jones, M, Kallepally, K, Kane, L, Kay, K, Kay, S, Keatley, J, Keith, A, King, A, Kitchin, L, Kleanthous, M, Klimekova, M, Korlevic, P, Krasheninnkova, K, Lane, G, Langford, C, Laverack, A, Law, K, Lawniczak, M, Lensing, S, Leonard, S, Letchford, L, Lewis, K, 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The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a9942c17abc60289ca896b8a872ae428
https://eprints.whiterose.ac.uk/182254/1/s41586-021-04069-y.pdf

Dynein and dynactin move long-range but are delivered separately to the axon tip.

Autor: Fellows AD; Division of Structural Studies, Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Bruntraeger M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Burgold T; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Bassett AR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Carter AP; Division of Structural Studies, Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

Publikováno v: The Journal of cell biology [J Cell Biol] 2024 May 06; Vol. 223 (5). Date of Electronic Publication: 2024 Feb 26.

Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson's Disease Independent of Mutations in MAPT.

Autor: Fernandes HJR; Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK., Kent JP; Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK.; Core Metabolomics and Lipidomics Laboratory, Institute of Metabolic Science, University of Cambridge, Level 4 Pathology, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Bruntraeger M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Bassett AR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Koulman A; Core Metabolomics and Lipidomics Laboratory, Institute of Metabolic Science, University of Cambridge, Level 4 Pathology, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Metzakopian E; Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0AH, UK., Snowden SG; Department of Biological Sciences, Royal Holloway University of London, Egham, London TW20 0EX, UK.

Publikováno v: Metabolites [Metabolites] 2023 Jan 09; Vol. 13 (1). Date of Electronic Publication: 2023 Jan 09.

Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells.

Autor: Rouhani FJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Zou X; Early Cancer Institute, Hutchison/MRC Research Centre, Cambridge Biomedical Research Campus, Cambridge, UK.; Academic Department of Medical Genetics, Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Cambridge, UK., Danecek P; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Badja C; Early Cancer Institute, Hutchison/MRC Research Centre, Cambridge Biomedical Research Campus, Cambridge, UK.; Academic Department of Medical Genetics, Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Cambridge, UK., Amarante TD; Early Cancer Institute, Hutchison/MRC Research Centre, Cambridge Biomedical Research Campus, Cambridge, UK., Koh G; Early Cancer Institute, Hutchison/MRC Research Centre, Cambridge Biomedical Research Campus, Cambridge, UK.; Academic Department of Medical Genetics, Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Cambridge, UK., Wu Q; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Memari Y; Early Cancer Institute, Hutchison/MRC Research Centre, Cambridge Biomedical Research Campus, Cambridge, UK., Durbin R; Department of Genetics, University of Cambridge, Cambridge, UK., Martincorena I; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Bassett AR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Gaffney D; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.; Genomics plc, King Charles House, Oxford, UK., Nik-Zainal S; Early Cancer Institute, Hutchison/MRC Research Centre, Cambridge Biomedical Research Campus, Cambridge, UK. sn206@cam.ac.uk.; Academic Department of Medical Genetics, Addenbrooke's Treatment Centre, Cambridge Biomedical Research Campus, Cambridge, UK. sn206@cam.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2022 Sep; Vol. 54 (9), pp. 1406-1416. Date of Electronic Publication: 2022 Aug 11.

The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour.

Autor: Castroflorio E; MRC Harwell Institute, Harwell Campus, Oxfordshire, OX11 0RD, UK., den Hoed J; Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK., Svistunova D; Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK., Finelli MJ; Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK., Cebrian-Serrano A; Wellcome Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK., Corrochano S; MRC Harwell Institute, Harwell Campus, Oxfordshire, OX11 0RD, UK.; Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos, Calle del Prof Martín Lagos s/n, 28040, Madrid, Spain., Bassett AR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Davies B; Wellcome Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK., Oliver PL; MRC Harwell Institute, Harwell Campus, Oxfordshire, OX11 0RD, UK. p.oliver@har.mrc.ac.uk.; Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK. p.oliver@har.mrc.ac.uk.

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