Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Bassem Shebl"'
Autor:
Bassem Shebl, Denise Ng, Gadi Lalazar, Carly Rosemore, Tova M. Finkelstein, Rachael D. Migler, Guangrong Zheng, Peiyi Zhang, Caroline S. Jiang, Adam Qureshi, Roger Vaughan, Mark Yarchoan, Ype P. de Jong, Charles M. Rice, Philip Coffino, Michael V. Ortiz, Daohong Zhou, Sanford M. Simon
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Fibrolamellar hepatocellular carcinoma (FLC) is a rare and often lethal liver cancer with no proven effective systemic therapy. Inhibition of the antiapoptotic protein BCL-XL was found to synergize with a variety of systemic therapies in vitro using
Externí odkaz:
https://doaj.org/article/ed56032357a1405693c5e939e308ce61
Autor:
Sanford M. Simon, Michael V. Ortiz, Michael S. Torbenson, Philip Coffino, Anthony Letai, Charles M. Rice, Michael P. LaQuaglia, Hans-Guido Wendel, Tomoaki Kato, Faith Tierney, Rory L. Smoot, Mark J. Truty, Jennifer L. Leiting, Martin Hertl, Erik Schadde, Jessica Ellison, Barbara A. Lyons, J. Fraser Glickman, Ethan M. Weinberg, James A. Saltsman, William J. Hammond, Benjamin A. Farber, Arlene M. Hurley, Koen O.A. Vercauteren, Mohammad Kabbani, Eleftherios Michailidis, Solomon Levin, Bassem Shebl, Nicole J.C. Narayan, Ruisi Wang, Ype P. de Jong, Patrick D. Bhola, Denise Ng, Lavoisier Ramos-Espiritu, David Requena, Gadi Lalazar
To repurpose therapeutics for fibrolamellar carcinoma (FLC), we developed and validated patient-derived xenografts (PDX) from surgical resections. Most agents used clinically and inhibitors of oncogenes overexpressed in FLC showed little efficacy on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2e6eadd89b35c3fbc11103d986522f
https://doi.org/10.1158/2159-8290.c.6549037.v1
https://doi.org/10.1158/2159-8290.c.6549037.v1
Autor:
Sanford M. Simon, Michael V. Ortiz, Michael S. Torbenson, Philip Coffino, Anthony Letai, Charles M. Rice, Michael P. LaQuaglia, Hans-Guido Wendel, Tomoaki Kato, Faith Tierney, Rory L. Smoot, Mark J. Truty, Jennifer L. Leiting, Martin Hertl, Erik Schadde, Jessica Ellison, Barbara A. Lyons, J. Fraser Glickman, Ethan M. Weinberg, James A. Saltsman, William J. Hammond, Benjamin A. Farber, Arlene M. Hurley, Koen O.A. Vercauteren, Mohammad Kabbani, Eleftherios Michailidis, Solomon Levin, Bassem Shebl, Nicole J.C. Narayan, Ruisi Wang, Ype P. de Jong, Patrick D. Bhola, Denise Ng, Lavoisier Ramos-Espiritu, David Requena, Gadi Lalazar
Supplementary Figure 1 - 6 and Supplementary Tables 1, 2, and 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b902995a0b627ef4461c460e313fed
https://doi.org/10.1158/2159-8290.22539256
https://doi.org/10.1158/2159-8290.22539256
Autor:
Sanford M. Simon, Michael V. Ortiz, Michael S. Torbenson, Philip Coffino, Anthony Letai, Charles M. Rice, Michael P. LaQuaglia, Hans-Guido Wendel, Tomoaki Kato, Faith Tierney, Rory L. Smoot, Mark J. Truty, Jennifer L. Leiting, Martin Hertl, Erik Schadde, Jessica Ellison, Barbara A. Lyons, J. Fraser Glickman, Ethan M. Weinberg, James A. Saltsman, William J. Hammond, Benjamin A. Farber, Arlene M. Hurley, Koen O.A. Vercauteren, Mohammad Kabbani, Eleftherios Michailidis, Solomon Levin, Bassem Shebl, Nicole J.C. Narayan, Ruisi Wang, Ype P. de Jong, Patrick D. Bhola, Denise Ng, Lavoisier Ramos-Espiritu, David Requena, Gadi Lalazar
List of compounds in the primary screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca221efe677664568327262bb0935e7f
https://doi.org/10.1158/2159-8290.22539253
https://doi.org/10.1158/2159-8290.22539253
Autor:
Ethan M. Weinberg, Michael Torbenson, Nicole J.C. Narayan, William J. Hammond, Gadi Lalazar, Ruisi Wang, Solomon Levin, Denise Ng, Michael P. LaQuaglia, Lavoisier Ramos-Espiritu, David Requena, J. Fraser Glickman, Barbara A. Lyons, Rory L. Smoot, Charles M. Rice, Eleftherios Michailidis, Jessica Ellison, Benjamin A. Farber, Erik Schadde, Hans-Guido Wendel, Koen Vercauteren, Faith Tierney, Arlene Hurley, Patrick Bhola, Mark J. Truty, Tomoaki Kato, Martin Hertl, Philip Coffino, Mohammad Kabbani, Anthony Letai, Jennifer L. Leiting, Ype P. de Jong, Bassem Shebl, Sanford M. Simon, James A. Saltsman, Michael V. Ortiz
Publikováno v:
Cancer Discov
To repurpose therapeutics for fibrolamellar carcinoma (FLC), we developed and validated patient-derived xenografts (PDX) from surgical resections. Most agents used clinically and inhibitors of oncogenes overexpressed in FLC showed little efficacy on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966cf4d6404337fbeea04a8fa44d7bd2
https://doi.org/10.1158/2159-8290.cd-20-0872
https://doi.org/10.1158/2159-8290.cd-20-0872
Autor:
Mahsa Shirani, Solomon Levin, Michael D. Tomasini, James Knox, Bassem Shebl, David Requena, Jackson Clark, Søren Heissel, Hanan Alwaseem, Rodrigo Surjan, Ron Lahasky, Henrik Molina, Barbara Lyons, Rachael D. Migler, Philip Coffino, Sanford M. Simon
Publikováno v:
Cancer Research. 83:6729-6729
In fibrolamellar hepatocellular carcinoma (FLC), hyperammonemic encephalopathy is a common occurrence and occasionally causes death. Using mass spectrometry, we quantitatively analyzed the proteomes of FLC patient’s tumor and adjacent normal, to fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::917e9d4d7428fb8a5021fd6b16226174
https://doi.org/10.1158/1538-7445.am2023-6729
https://doi.org/10.1158/1538-7445.am2023-6729
Autor:
Nicole J.C. Narayan, David Requena, Gadi Lalazar, Lavoisier Ramos-Espiritu, Denise Ng, Solomon Levin, Bassem Shebl, Ruisi Wang, William J. Hammond, James A. Saltsman, Helmuth Gehart, Michael S. Torbenson, Hans Clevers, Michael P. LaQuaglia, Sanford M. Simon
Publikováno v:
Stem Cell Reports, 17(8), 1874-1888. Cell Press
Stem Cell Reports, 17 (8)
Stem Cell Reports, 17 (8)
Fibrolamellar carcinoma (FLC) is a rare, often lethal, liver cancer affecting adolescents and young adults, for which there are no approved therapeutics. The development of therapeutics is hampered by a lack of in vitro models. Organoids have shown u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37304e3e13386ba989814f730535fbd0
Autor:
Bassem Shebl, Gadi Lalazar, Denise Ng, Tova Finkelstein, Guangrong Zheng, Peiyi Zhang, Carly Rosemore, Michael Ortiz, Daohong Zhou, Sanford Simon, Philip Coffino
Publikováno v:
Cancer Research. 82:3888-3888
Fibrolamellar hepatocellular carcinoma (FLC) is a lethal pediatric cancer affecting adolescents and young adults. Besides surgical resection, there is no approved and effective therapy. FLC is driven by a fusion oncokinase, DNAJB1-PRKACA, that arises
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a27eff6abc7ef337b4e8ece3d5ceb6a
https://doi.org/10.1158/1538-7445.am2022-3888
https://doi.org/10.1158/1538-7445.am2022-3888
Publikováno v:
Archives of Biochemistry and Biophysics. 603:118-130
During the past decade, single-molecule studies of the ribosome have significantly advanced our understanding of protein synthesis. The broadest application of these methods has been towards the investigation of ribosome conformational dynamics using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4690a3267a6901011478381c498efe51
https://doi.org/10.1016/j.abb.2016.05.010
https://doi.org/10.1016/j.abb.2016.05.010
Autor:
Gadi Lalazar, Hans Clevers, Nicole J. Croteau, Denise Ng, Michael P. LaQuaglia, Bassem Shebl, Sanford M. Simon, Helmuth Gehart, David Requena, William J. Hammond, Ruisi Wang, Solomon Levin, James A. Saltsman
Publikováno v:
Cancer Research. 80:3905-3905
Fibrolamellar Hepatocellular Carcinoma (FLC) is a usually lethal liver cancer affecting adolescents and young adults without previous liver disease. FLC is characterized by a ~400kb nucleotide deletion resulting in a fusion of a heatshock protein cof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7871506ad4eca05bd93cf44d3ead6179
https://doi.org/10.1158/1538-7445.am2020-3905
https://doi.org/10.1158/1538-7445.am2020-3905