Synthesis, Photophysical Characterization and Evaluation of Biological Properties of C7, a Novel Symmetric Tetra-Imidazolium-Bis-Heterocycle

Autor: Hannah Kunstek, Melaine Wang, Hiba Hussein, Ines Dhouib, Bassem Khemakhem, Arnaud Risler, Stephanie Philippot, Celine Frochot, Philippe Arnoux, Bertrand Fournier, Mihayl Varbanov, Florence Dumarçay-Charbonnier

Publikováno v: Microorganisms, Vol 11, Iss 2, p 495 (2023)

A novel symmetric tetra-imidazolium-bis-heterocycle, called C7, was designed and synthesized in a quick two-step pathway, with the objective to synthesize biologically active supramolecular assembly. The synthesized compound was then analyzed for its

Externí odkaz: https://doaj.org/article/5c801670fb09485e9f534312e6b441bd

Apigenin analogues as SARS-CoV-2 main protease inhibitors: In-silico screening approach

Autor: Ameny Farhat, Hajer Ben Hlima, Bassem Khemakhem, Youssef Ben Halima, Philippe Michaud, Slim Abdelkafi, Imen Fendri

Publikováno v: Bioengineered
Bioengineered, 2022, 13 (2), pp.3350--3361. ⟨10.1080/21655979.2022.2027181⟩
Bioengineered, Vol 13, Iss 2, Pp 3350-3361 (2022)

International audience; The COVID-19 new variants spread rapidly all over the world, and until now scientists strive to find virus-specific antivirals for its treatment. The main protease of SARS-CoV-2 (Mpro) exhibits high structural and sequence hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649222ba87dbf542f79758a54c49153f
https://hal.uca.fr/hal-03624323/file/21655979.2022.pdf

Synthesis, bioassay and molecular docking of novel pyrazole and pyrazolone derivatives as acetylcholinesterase inhibitors

Autor: Mehdi Messaad, Ines Dhouib, Mohamed Abdelhedi, Bassem Khemakhem

Publikováno v: Journal of Molecular Structure. 1263:133105

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13e83323fa51feb28c157fde0e060f29
https://doi.org/10.1016/j.molstruc.2022.133105

In silico evidence of antiviral activity against SARS-CoV-2 main protease of oligosaccharides from Porphyridium sp

Autor: Hajer Ben Hlima, Ameny Farhat, Sarra Akermi, Bassem Khemakhem, Youssef Ben Halima, Philippe Michaud, Imen Fendri, Slim Abdelkafi

Publikováno v: Science of the Total Environment
Science of the Total Environment, 2022, 836, pp.155580. ⟨10.1016/j.scitotenv.2022.155580⟩

The coronavirus pandemic (COVID-19) has created an urgent need to develop effective strategies for prevention and treatment. In this context, therapies against protease M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e94f1626136e10884ad539b6e516e4
https://doi.org/10.1016/j.scitotenv.2022.155580

Antioxidant, Anti-Inflammatory, and Antitumoral Effects of Aqueous Ethanolic Extract from Phoenix dactylifera L. Parthenocarpic Dates

Autor: Bassem Khemakhem, Naziha Marrakchi, Noureddine Drira, Zaineb Abdelkafi-Koubaa, M Chakroun, Hanen El Abed, Hafedh Mejdoub

Publikováno v: BioMed Research International
BioMed Research International, Hindawi Publishing Corporation, 2018, 2018, pp.1542602. ⟨10.1155/2018/1542602⟩
BioMed Research International, Vol 2018 (2018)

The aim of this study was to evaluate the antioxidant, the anti-inflammatory, and the antitumoral activities of the aqueous ethanolic extract fromPhoenix dactyliferaL. parthenocarpic dates. The antioxidant activity was carried using DPPH radical scav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509d492f0f4d8a3f5fefc1cda1f9d1ea
https://hal-riip.archives-ouvertes.fr/pasteur-01990509