Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Bassem Ben Yahia"'
Autor:
Cyrielle Calmels, Solène Arnoult, Bassem Ben Yahia, Laetitia Malphettes, Mikael Rørdam Andersen
Publikováno v:
Metabolic Engineering Communications, Vol 9, Iss , Pp - (2019)
Biopharmaceutical industrial processes are based on high yielding stable recombinant Chinese Hamster Ovary (CHO) cells that express monoclonal antibodies. However, the process and feeding regimes need to be adapted for each new cell line, as they all
Externí odkaz:
https://doaj.org/article/6b099d7f904f44c0a2af362e0e25076f
Publikováno v:
Biotechnology and Bioengineering.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2b329d6fbe675ffdf18a93597e2b860
https://doi.org/10.1002/bit.28396
https://doi.org/10.1002/bit.28396
Publikováno v:
Metabolic Engineering. 66:204-216
We describe a systematic approach to establish predictive models of CHO cell growth, cell metabolism and monoclonal antibody (mAb) formation during biopharmaceutical production. The prediction is based on a combination of an empirical metabolic model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3e70262fa818268ffc96063588387e
https://doi.org/10.1016/j.ymben.2021.04.004
https://doi.org/10.1016/j.ymben.2021.04.004
Publikováno v:
Biotechnology and Bioengineering. 114:785-797
We describe a systematic approach to model CHO metabolism during biopharmaceutical production across a wide range of cell culture conditions. To this end, we applied the metabolic steady state concept. We analyzed and modeled the production rates of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4edadf86dba5d480cb62e3a5d8922502
https://doi.org/10.1002/bit.26214
https://doi.org/10.1002/bit.26214
Publikováno v:
Applied Microbiology and Biotechnology
We review major modeling strategies and methods to understand and simulate the macroscopic behavior of mammalian cells. These strategies comprise two important steps: the first step is to identify stoichiometric relationships for the cultured cells c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e5cbabd234ddd504518bbb7008bc4f
http://europepmc.org/articles/PMC4536272
http://europepmc.org/articles/PMC4536272
Autor:
Grégory Mathy, Guillaume Le Reverend, Nicola Bonsu-Dartnall, Laura Gimenez, Bassem Ben Yahia, Laetitia Malphettes, Jimmy Stofferis, Marie-Françoise Clincke, Boris Fessler
Publikováno v:
BMC Proceedings
Background Current trend towards Quality by Design (QbD) leads the process development exercise towards systematic experimentation, rational development, process understanding, characterization and control. In this study, an example of the applicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5ecd88b3cab204fb59b5c926532fe2
https://doi.org/10.1186/1753-6561-7-s6-p78
https://doi.org/10.1186/1753-6561-7-s6-p78